mrm29127-sup-0001-Supinfo.docxWord 2007 document , 1.4 MB

FIGURE S1 Simulation for flip angle optimization. TR was fixed to 7 ms, T1 was varied within 100–1500 ms with a step of 1 ms. (A) Sum of DR × FS for all T1s under each flip angle combination. (B) Sum of DR × FS for all T1s when was varied with 0°–90°, and was fixed to 3°. DR, dynamic range; FS, fraction signal of the points

FIGURE S2 The mNSA of and water estimation in three point fat-water signal model under different TE combinations with = 40 s−1, given TE1 = 1.52 ms (solid line) and TE1 = 2.4 ms (dotted line). The TE combination of the in-vivo scan was marked with red dot and the TE combination of phantom scan was marked with red star

FIGURE S3 ROI analysis of the T1,w, T1,f, PDFF, and value in the volunteers. Three ROIs are drawn in each image for T1,w PDFF, and , while three different ROIs in the subcutaneous fat area are drawn for T1,f (ROIs 4–6). The mean and standard deviation of the values in each ROI are summarized in the table

FIGURE S4 ROI analysis of the T1,w and T1,f results with/without correction in two volunteers. Three ROIs are drawn in each image for T1,w and three for T1,f. The mean and standard deviation of the values in each ROI are compared in the boxplots

FIGURE S5 T1,w and T1,f maps with/without correction in two volunteers

TABLE S1 PDFF, T2,w, T2,f, T1,w, T1,f of each vial estimated from the spectroscopic data