This study aimed to assess water sorption and solubility of CAD/CAM composite blocks compared to CAD/CAM ceramic after 8 months storage in water and artificial saliva. Eight CAD/CAM blocks were investigated: Five resin-composite blocks (RCBs), one polymer-infiltrated ceramic network (PICN) block, one ceramic-filled polyetheretherketone (PEEK) block, and one feldspathic ceramic block. One hundred and twelve specimens were prepared comprising 14 specimens of each of the eight materials. From each group of specimens, seven randomly selected specimens were immersed in 10 mL of water, while the other seven specimens were immersed in artificial saliva. All specimens were stored at 37°C and weighed at various time intervals. The data were analysed via repeat measures ANOVA, one-way ANOVA and Tukey's post hoc test (α = 0.05 for all tests). Sorption values (mean [SD]) in water were within the range -1.21 (0.4) to 39.3 (2.1) μg/mm3 and in artificial saliva between -0.7 (0.2) and 41.6 (1.3) μg/mm3. Solubility values in water were between -0.43 (0.08) and 0.34 (0.18) μg/mm3 and in artificial saliva between -0.53 (0.07) μg/mm3 and 0.33 (0.2) μg/mm3. CAD/CAM composite blocks were hydrolytically stable under long-term storage (according to ISO 4949:2009), although not as stable as ceramic. Water sorption of CAD/CAM composite blocks was dependent on the resin-matrix and was influenced by the filler weight %.