1. Ziegler-Graham, K, MacKenzie, EJ, Ephraim, PL, Travison, TG, Brookmeyer, R. Estimating the prevalence of limb loss in the United States: 2005 to 2050. Arch Phys Med Rehabil. 2008;89(3):422-429.
Google Scholar | Crossref | Medline | ISI2. Weeks, SR, Anderson-Barnes, VC, Tsao, JW. Phantom limb pain: theories and therapies. Neurol. 2010;16(5):277-286.
Google Scholar3. Ortiz-Catalan, M . The stochastic entanglement and phantom motor execution hypotheses: a theoretical framework for the origin and treatment of PLP. Front Neurol. 2018;9:748.
Google Scholar | Crossref | Medline4. Sherman, RA, Sherman, CJ, Gall, NG. A survey of current phantom limb pain treatment in the United States. Pain. 1980;8(1):85-99.
Google Scholar | Crossref | Medline5. Melzack, R . The short-form McGill pain auestionnaire. Pain. 1987;30:191-197.
Google Scholar | Crossref | Medline | ISI6. Pons, TP, Garraghty, PE, Ommaya, AK, Kaas, JH, Taub, E, Mishkin, M. Massive cortical reorganization after sensory deafferentation in adult macaques. Science. 1991;252(5014):1857-1860.
Google Scholar | Crossref | Medline | ISI7. Halligan, PW, Marshall, JC, Wade, DT, Davey, J, Morrison, D. Thumb in cheek? Sensory reorganization and perceptual plasticity after limb amputation. Neuroreport. 1993;4(3):233-236.
Google Scholar | Crossref | Medline8. Ramachandran, VS . Behavioral and magnetoencephalographic correlates of plasticity in the adult human brain. Proc Natl Acad Sci U S A. 1993;90(22):10413.
Google Scholar | Crossref | Medline9. Flor, H, Elbert, T, Knecht, S, et al. Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation. Nature. 1995;375(6531):482-484.
Google Scholar | Crossref | Medline | ISI10. Lotze, M, Flor, H, Grodd, W, Larbig, W, Birbaumer, N. Phantom movements and pain An fMRI study in upper limb amputees. Brain. 2001;124(11):2268-2277.
Google Scholar | Crossref | Medline11. Kikkert, S, Kolasinski, J, Jbabdi, S, et al. Revealing the neural fingerprints of a missing hand. Elife. 2016;5:e15292.
Google Scholar | Crossref | Medline12. Kikkert, S, Johansen-Berg, H, Tracey, I, Makin, TR. Reaffirming the link between chronic phantom limb pain and maintained missing hand representation. Cortex. 2018;106:174-184.
Google Scholar | Crossref | Medline13. Makin, TR, Scholz, J, Filippini, N, Slater, DH, Tracey, I, Johansen-Berg, H. Phantom pain is associated with preserved structure and function in the former hand area. Nat Commun. 2013;4(1):1-8.
Google Scholar | Crossref14. Raffin, E, Richard, N, Giraux, P, Reilly, KT. Primary motor cortex changes after amputation correlate with phantom limb pain and the ability to move the phantom limb. Neuroimage. 2016;130:134-144.
Google Scholar | Crossref | Medline15. Harris, AJ . Cortical origin of pathological pain. Lancet. 1999;354(9188):1464-1466.
Google Scholar | Crossref | Medline16. Kikkert, S, Mezue, M, Slater, DH, Johansen-Berg, H, Tracey, I, Makin, TR. Motor correlates of phantom limb pain. Cortex. 2017;95:29-36.
Google Scholar | Crossref | Medline17. Gagné, M, Reilly, KT, Hetu, S, Mercier, C. Motor control over the phantom limb in above-elbow amputees and its relationship with phantom limb pain. Neurosci. 2009;162(1):78-86.
Google Scholar | Crossref18. Ramachandran, VS, Hirstein, W. The perception of phantom limbs. The DO Hebb lecture. Brain. 1998;121(9):1603-1630.
Google Scholar | Crossref | Medline | ISI19. Diers, M, Christmann, C, Koeppe, C, Ruf, M, Flor, H. Mirrored imagined and executed movements differentially activate sensorimotor cortex in amputees with and without phantom limb pain. Pain. 2010;149(2):296-304.
Google Scholar | Crossref | Medline | ISI20. Foell, J, Bekrater‐Bodmann, R, Diers, M, Flor, H. Mirror therapy for phantom limb pain: brain changes and the role of body representation. Eur J Pain. 2014;18(5):729-739.
Google Scholar | Crossref | Medline21. Soechting, JF, Flanders, M. Errors in pointing are due to approximations in sensorimotor transformations. J Neurophysiol. 1989;62(2):595-608.
Google Scholar | Crossref | Medline22. Ambron, E, Miller, A, Connor, S, Coslett, HB. Virtual image of a hand displaced in space influences action performance of the real hand. Sci Rep. 2020;10(1):1-11.
Google Scholar | Crossref | Medline23. Mercier, C, Sirigu, A. Training with virtual visual feedback to alleviate phantom limb pain. Neurorehabilitation Neural Repair. 2009;23(6):587-594.
Google Scholar | SAGE Journals | ISI24. Murray, CD, Patchick, E, Pettifer, S, Caillette, F, Howard, T. Immersive virtual reality as a rehabilitative technology for phantom limb experience: a protocol. CyberPsychology Behav. 2006;9(2):167-170.
Google Scholar | Crossref | Medline25. Murray, CD, Patchick, E, Pettifer, S, et al. Investigating the efficacy of a virtual mirror box in treating phantom limb pain in a sample of chronic sufferers. Int J Disabil Hum Dev. 2006;5(3):227-234.
Google Scholar | Crossref26. Osumi, M, Inomata, K, Inoue, Y, Otake, Y, Morioka, S, Sumitani, M. Characteristics of phantom limb pain alleviated with virtual reality rehabilitation. Pain Med. 2019;20(5):1038-1046.
Google Scholar | Crossref | Medline27. Sano, Y, Wake, N, Ichinose, A, et al. Tactile feedback for relief of deafferentation pain using virtual reality system: a pilot study. J NeuroEng Rehabil. 2016;13(1):61.
Google Scholar | Crossref | Medline28. Chau, B, Phelan, I, Ta, P, Humbert, S, Hata, J, Tran, D. Immersive virtual reality therapy with myoelectric control for treatment-resistant phantom limb pain: Case report. Innov Clin Neurosci. 2017;14(7-8):3-7.
Google Scholar | Medline29. Ortiz-Catalan, M, Sander, N, Kristoffersen, MB, Håkansson, B, Brånemark, R. Treatment of phantom limb pain (PLP) based on augmented reality and gaming controlled by myoelectric pattern recognition: a case study of a chronic PLP patient. Front Neurosci. 2014:8-24.
Google Scholar | Medline30. Ortiz-Catalan, M, Guðmundsdóttir, RA, Kristoffersen, MB, et al. Phantom motor execution facilitated by machine learning and augmented reality as treatment for phantom limb pain: a single group clinical trial in patients with chronic intractable phantom limb pain. Lancet. 2016;388(10062):2885-2894.
Google Scholar | Crossref | Medline31. Perry, BN, Mercier, C, Pettifer, SR, Cole, J, Tsao, JW. Virtual reality therapies for phantom limb pain. Eur J Pain. 2014;18(7):897-899.
Google Scholar | Crossref | Medline32. Lendaro, E, Mastinu, E, Håkansson, B, Ortiz-Catalan, M. Real-time classification of non-weight bearing lower-limb movements using EMG to facilitate phantom motor execution: engineering and case study application on phantom limb pain. Front Neurol. 2017;8:470.
Google Scholar | Crossref | Medline33. Perry, BN, Armiger, RS, Wolde, M, et al. Clinical trial of the virtual integration environment to treat phantom limb pain with upper extremity amputation. Front Neurol. 2018;9:770.
Google Scholar | Crossref | Medline34. Nissler, C, Nowak, M, Connan, M, et al. Vita—an everyday virtual reality setup for prosthetics and upper-limb rehabilitation. J Neural Eng. 2019;16(2):026039.
Google Scholar | Crossref | Medline35. Cole, J, Crowle, S, Austwick, G, Henderson Slater, D. Exploratory findings with virtual reality for phantom limb pain; from stump motion to agency and analgesia. Disabil Rehabil. 2009;31(10):846-854.
Google Scholar | Crossref | Medline36. Rutledge, T, Velez, D, Depp, C, et al. A virtual reality intervention for the treatment of phantom limb pain: development and feasibility results. Pain Med. 2019;20(10):2051-2059.
Google Scholar | Crossref | Medline37. Rothgangel, A, Braun, S, Winkens, B, Beurskens, A, Smeets, R. Traditional and augmented reality mirror therapy for patients with chronic phantom limb pain (PACT study): results of a three-group multicentre single-blind randomized controlled trial. Clin Rehabil. 2018;32(12):1591-1608.
Google Scholar | SAGE Journals | ISI38. Ambron, E, Miller, A, Kuchenbecker, KJ, Buxbaum, LJ, Coslett, H. Immersive low-cost virtual reality treatment for phantom limb pain: Evidence from two cases. Front Neurol. 2018;9:67.
Google Scholar | Crossref | Medline39. Jones, T, Moore, T, Choo, J. The impact of virtual reality on chronic pain. PLoS One. 2016;11(12):e0167523.
Google Scholar | Crossref | Medline40. Nasreddine, ZS, Phillips, NA, Bédirian, V, et al. The Montreal cognitive assessment MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53(4):695-699.
Google Scholar | Crossref | Medline | ISI41. Merzenich, MM, Nelson, RJ, Stryker, MP, Cynader, MS, Schoppmann, A, Zook, JM. Somatosensory cortical map changes following digit amputation in adult monkeys. J comparative Neurol. 1984;224(4):591-605.
Google Scholar | Crossref | Medline | ISI42. Cleeland, CS, Ryan, KM. Pain assessment: global use of the Brief Pain Inventory. Ann Acad Med Singapore. 1994;23:129-138.
Google Scholar | Medline43. Kennedy, RS, Lane, NE, Berbaum, KS, Lilienthal, MG. Simulator sickness questionnaire: an enhanced method for quantifying simulator sickness. Int J Aviat Psychol. 1993;3(3):203-220.
Google Scholar | Crossref44. Brooke, JSUS . A “quick and dirty” usability scale. In: PWBBA, JordanThomasWeerdmeester, IL, McClelland, eds Usability evaluation in industry: Taylor & Francis; 1996:189-194.
Google Scholar45. Slater, M, Usoh, M, Steed, A. Depth of presence in virtual environments. Presence Teleoperators Virtual Environ. 1994;3(2):130-144.
Google Scholar | Crossref46. Busk, PL, Serlin, RC, Kratochwill, TR, Levin, JR. Single-case research design and analysis: New directions for psychology and education; 1992.
Google Scholar47. Beeson, PM, Robey, RR. Evaluating single-subject treatment research: lessons learned from the aphasia literature. Neuropsychol Rev. 2006;16(4):161-169.
Google Scholar | Crossref | Medline48. Collingridge, DS . A primer on quantitized data analysis and permutation testing. J Mix Methods Res. 2013;7(1):81-97.
Google Scholar | SAGE Journals | ISI49. Goller, AI . Perceptual abnormalities in amputees: phantom pain mirror-touch synaesthesia and referred tactile sensations (Doctoral dissertation University of Sussex); 2012.
Google Scholar50. Perry, BN, Alphonso, AL, Tsao, JW, Pasquina, PF, Armiger, RS, Moran, CW. A virtual integrated environment for phantom limb pain treatment and modular prosthetic limb training. In International Conference on Virtual Rehabilitation (ICVR); 2013.
Google Scholar51. Pourmand, A, Davis, S, Marchak, A, Whiteside, T, Sikka, N. Virtual reality as a clinical tool for pain management. Curr Pain Headache Rep. 2018;22(8):53.
Google Scholar | Crossref | Medline52. So, RH, Ho, A, Lo, WT. A metric to quantify virtual scene movement for the study of cybersickness: Definition implementation and verification. Presence Teleoperators Virtual Environ. 2001;10(2):193-215.
Google Scholar |