1. Lenders, JW, Eisenhofer, G, Mannelli, M, et al. Phaeochromocytoma. Lancet 2005; 366(9486): 665–675.
Google Scholar | Crossref | Medline | ISI2. Manger, WM . The protean manifestations of pheochromocytoma. Horm Metab Res 2009; 41(9): 658–663.
Google Scholar | Crossref | Medline | ISI3. Prejbisz, A, Lenders, JWM, Eisenhofer, G, et al. Cardiovascular manifestations of phaeochromocytoma. J Hypertens 2011; 29(11): 2049–2060.
Google Scholar | Crossref | Medline | ISI4. Crona, J, Taïeb, D, Pacak, K. New perspectives on pheochromocytoma and paraganglioma: toward a molecular classification. Endocr Rev 2017; 38(6): 489–515.
Google Scholar | Crossref | Medline5. Aron, D, Terzolo, M, Cawood, TJ. Adrenal incidentalomas. Best Pract Res Clin Endocrinol Metab 2012; 26(1): 69–82.
Google Scholar | Crossref | Medline6. Lenders, JWM, Pacak, K, Walther, MM, et al. Biochemical diagnosis of pheochromocytoma. JAMA 2002; 287(11): 1427–1434.
Google Scholar | Crossref | Medline7. Pisano, JJ . A simple analysis for normetanephrine and metanephrine in urine. Clinica Chim Acta Int J Clin Chem 1960; 5: 406–414.
Google Scholar | Crossref | Medline | ISI8. Stroes, JW, Putters, J, van Rijn, HJM. An improved spectrophotometric procedure for the determination of urinary metanephrines. Clin Chem Lab Med 1987; 25(8): 483–486.
Google Scholar | Crossref9. Wassell, J, Reed, P, Kane, J, et al. Freedom from drug interference in new immunoassays for urinary catecholamines and metanephrines. Clin Chem 1999; 45(12): 2216–2223.
Google Scholar | Crossref | Medline10. Weismann, D, Peitzsch, M, Raida, A, et al. Measurements of plasma metanephrines by immunoassay vs liquid chromatography with tandem mass spectrometry for diagnosis of pheochromocytoma. Eur J Endocrinol 2015; 172(3): 251–260.
Google Scholar | Crossref | Medline11. Weicker, H, Feraudi, M, Hägele, H, et al. Electrochemical detection of catecholamines in urine and plasma after separation with HPLC. Clinica Chim Acta 1984; 141(1): 17–25.
Google Scholar | Crossref | Medline12. Lenders, JW, Eisenhofer, G, Armando, I, et al. Determination of metanephrines in plasma by liquid chromatography with electrochemical detection. Clin Chem 1993; 39(1): 97–103.
Google Scholar | Crossref | Medline13. Taylor, RL, Singh, RJ. Validation of liquid chromatography-tandem mass spectrometry method for analysis of urinary conjugated metanephrine and normetanephrine for screening of pheochromocytoma. Clin Chem 2002; 48(3): 533–539.
Google Scholar | Crossref | Medline14. Peaston, RT, Graham, KS, Chambers, E, et al. Performance of plasma free metanephrines measured by liquid chromatography-tandem mass spectrometry in the diagnosis of pheochromocytoma. Clinica Chim Acta Int J Clin Chem 2010; 411(7–8): 546–552.
Google Scholar | Crossref | Medline15. Mullins, F, O’Shea, P, FitzGerald, R, et al. Enzyme-linked immunoassay for plasma-free metanephrines in the biochemical diagnosis of phaeochromocytoma in adults is not ideal. Clin Chem Lab Med 2011; 50(1): 105–110.
Google Scholar | Medline16. Därr, R, Pamporaki, C, Peitzsch, M, et al. Biochemical diagnosis of phaeochromocytoma using plasma-free normetanephrine, metanephrine and methoxytyramine: importance of supine sampling under fasting conditions. Clin Endocrinol 2014; 80(4): 478–486.
Google Scholar | Crossref | Medline17. Eisenhofer, G, Goldstein, DS, Walther, MM, et al. Biochemical diagnosis of pheochromocytoma: how to distinguish true- from false-positive test results. J Clin Endocrinol Metab 2003; 88(6): 2656–2666.
Google Scholar | Crossref | Medline | ISI18. Peaston, RT, Ball, S. Biochemical detection of phaeochromocytoma: why are we continuing to ignore the evidence? Ann Clin Biochem 2008; 45(Pt 1): 6–10.
Google Scholar | SAGE Journals19. Lenders, JWM, Duh, QY, Eisenhofer, G, et al. Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2014; 99(6): 1915–1942.
Google Scholar | Crossref | Medline | ISI20. Peitzsch, M, Prejbisz, A, Kroiss, M, et al. Analysis of plasma 3-methoxytyramine, normetanephrine and metanephrine by ultraperformance liquid chromatography-tandem mass spectrometry: utility for diagnosis of dopamine-producing metastatic phaeochromocytoma. Ann Clin Biochem 2013; 50(Pt 2): 147–155.
Google Scholar | SAGE Journals21. Boyle, JG, Davidson, DF, Perry, CG, et al. Comparison of diagnostic accuracy of urinary free metanephrines, vanillyl mandelic Acid, and catecholamines and plasma catecholamines for diagnosis of pheochromocytoma. J Clin Endocrinol Metab 2007; 92(12): 4602–4608.
Google Scholar | Crossref | Medline22. Hickman, PE, Leong, M, Chang, J, et al. Plasma free metanephrines are superior to urine and plasma catecholamines and urine catecholamine metabolites for the investigation of phaeochromocytoma. Pathology 2009; 41(2): 173–177.
Google Scholar | Crossref | Medline23. Popovici, T, Moreira, B, Schlageter, MH, et al. Automated two-site immunofluorescent assay for the measurement of serum chromogranin A. Clin Biochem 2014; 47(1–2): 87–91.
Google Scholar | Crossref | Medline | ISI24. Algeciras-Schimnich, A, Preissner, CM, Young, WF, et al. Plasma chromogranin A or urine fractionated metanephrines follow-up testing improves the diagnostic accuracy of plasma fractionated metanephrines for pheochromocytoma. J Clin Endocrinol Metab 2008; 93(1): 91–95.
Google Scholar | Crossref | Medline25. Grossrubatscher, E, Dalino, P, Vignati, F, et al. The role of chromogranin A in the management of patients with phaeochromocytoma. Clin Endocrinol 2006; 65(3): 287–293.
Google Scholar | Crossref | Medline26. Bílek, R, Vlček, P, Šafařík, L, et al. Chromogranin A in the laboratory diagnosis of pheochromocytoma and paraganglioma. Cancers 2019; 11(4): 586.
Google Scholar | Crossref27. Bech, PR, Ramachandran, R, Dhillo, WS, et al. Quantifying the effects of renal impairment on plasma concentrations of the neuroendocrine neoplasia biomarkers chromogranin A, chromogranin B, and cocaine- and amphetamine-regulated transcript. Clin Chem 2012; 58(5): 941–943.
Google Scholar | Crossref | Medline28. Plouin, PF, Amar, L, Dekkers, OM, et al. European society of endocrinology clinical practice guideline for long-term follow-up of patients operated on for a phaeochromocytoma or a paraganglioma. Eur J Endocrinol 2016; 174: G1–G10.
Google Scholar | Crossref | Medline | ISI29. Ramachandran, R, Bech, P, Murphy, KG, et al. Improved diagnostic accuracy for neuroendocrine neoplasms using two chromogranin A assays. Clin Endocrinol 2012; 76: 831–836.
Google Scholar | Crossref | Medline | ISI30. Hui, TP, Krakoff, LR, Felton, K, et al. Diuretic treatment alters clonidine suppression of plasma norepinephrine. Hypertension 1986; 8: 272–276.
Google Scholar | Crossref | Medline31. Sjoberg, RJ, Simcic, KJ, Kidd, GS. The clonidine suppression test for pheochromocytoma. A review of its utility and pitfalls. Acrh Intern Med 1992; 152: 1193–1197.
Google Scholar | Crossref | Medline32. Rao, D, Peitzsch, M, Prejbisz, A, et al. Plasma methoxytyramine: clinical utility with metanephrines for diagnosis of pheochromocytoma and paraganglioma. Eur J Endocrinol 2017; 177: 103–113.
Google Scholar | Crossref | Medline33. Peitzsch, M, Novos, T, Kaden, D, et al. Harmonization of LC-MS/MS Measurements of Plasma Free Normetanephrine, Metanephrine, and 3-Methoxytyramine. Clin Chem 2021; 67: 1098–1112.
Google Scholar | Crossref | Medline34. Lenders, JW, Willemsen, JJ, Eisenhofer, G, et al. Is supine rest necessary before blood sampling for plasma metanephrines? Clin Chem 2007; 53: 352–354.
Google Scholar | Crossref | Medline | ISI35. Eisenhofer, G, Prejbisz, A, Peitzsch, M, et al. Biochemical diagnosis of chromaffin cell tumors in patients at high and low risk of disease: plasma versus urinary free or deconjugated O-Methylated Catecholamine metabolites. Clin Chem 2018; 64: 1646–1656.
Google Scholar | Crossref | Medline36. Boot, C, Toole, B, Johnson, SJ, et al. Single-centre study of the diagnostic performance of plasma metanephrines with seated sampling for the diagnosis of phaeochromocytoma/paraganglioma. Ann Clin Biochem 2016; 54: 143–148.
Google Scholar | SAGE Journals37. Chortis, V, Bancos, I, Crowley, RK, et al. Supine or sitting? Economic considerations regarding patient position during plasma metanephrine analysis for the exclusion of chromaffin tumours. Clin Endocrinol 2014; 82: 462–463.
Google Scholar | Crossref | Medline | ISI38. Willemsen, JJ, Ross, HA, Lenders, JW, et al. Stability of urinary fractionated metanephrines and catecholamines during collection, shipment, and storage of samples. Clin Chem 2007; 53: 268–272.
Google Scholar | Crossref | Medline | ISI39. Roberts, NB, Higgins, G, Sargazi, M. A study on the stability of urinary free catecholamines and free methyl-derivatives at different pH, temperature and time of storage. Clin Chem Lab Med 2010; 48: 81–87.
Google Scholar | Crossref | Medline | ISI40. Eugster, PJ, Centeno, C, Dunand, M, et al. Stabilization of urinary biogenic amines measured in clinical chemistry laboratories. Clinica Chim Acta 2021; 514: 24–28.
Google Scholar | Crossref | Medline41. Peitzsch, M, Kaden, D, Pamporaki, C, et al. Overnight/first-morning urine free metanephrines and methoxytyramine for diagnosis of pheochromocytoma and paraganglioma: is this an option? Eur J Endocrinol 2020; 182(5): 499–509.
Google Scholar | Crossref | Medline42. Zuo, M, Zhen, Q, Zhang, X, et al. High specificity of spot urinary free metanephrines in diagnosis and prognosis of pheochromocytomas and paragangliomas by HPLC with electrochemical detection. Clinica Chim Acta 2018; 478: 82–89.
Google Scholar | Crossref | Medline43. Sbardella, E, Maunsell, Z, May, CJH, et al. Random ‘spot’ urinary metanephrines compared with 24-h-urinary and plasma results in phaeochromocytomas and paragangliomas. Eur J Endocrinol 2020; 183(2): 129–139.
Google Scholar | Crossref | Medline44. Danese, E, Montagnana, M, Brentegani, C, et al. Short-term stability of free metanephrines in plasma and whole blood. Clin Chem Lab Med 2020; 58: 753–757.
Google Scholar | Crossref | Medline45. Willemsen, JJ, Sweep, CG, Lenders, JW, et al. Stability of plasma free metanephrines during collection and storage as assessed by an optimized HPLC method with electrochemical detection. Clin Chem 2003; 49: 1951–1953.
Google Scholar | Crossref | Medline | ISI46. Eisenhofer, G, Brown, S, Peitzsch, M, et al. Levodopa therapy in Parkinson’s disease: influence on liquid chromatographic tandem mass spectrometric-based measurements of plasma and urinary normetanephrine, metanephrine and methoxytyramine. Ann Clin Biochem 2013; 51: 38–46.
Google Scholar | SAGE Journals47. Peitzsch, M, Adaway, JE, Eisenhofer, G. Interference from 3-O-methyldopa with ultra-high performance LC-MS/MS measurements of plasma metanephrines: chromatographic separation remains important. Clin Chem 2015; 61: 993–996.
Google Scholar |