JM Arguiñano Pérez has served as a consultant to Janssen, BMS-Celgene and Amgen.

S Corman, K Verleger and C Johnson are employees of OPEN Health, which received funding from Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited for this study.

D Cherepanov and D Romanus are employees of Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited.

M Grande is an employee of Takeda Farmaceutica España. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Medical writing support was provided by C DuVernay of Pharmerit International.