1.
Abraham, DJ, Varga, J. Scleroderma: from cell and molecular mechanisms to disease models. Trends Immunol 2005; 26(11): 587–595.
Google Scholar |
Crossref |
Medline2.
Kahaleh, B. The microvascular endothelium in scleroderma. Rheumatology 2008; 47(Suppl. 5): V14–V15.
Google Scholar |
Crossref |
Medline3.
Rajendran, P, Rengarajan, T, Thangavel, J, et al. The vascular endothelium and human diseases. Int J Biol Sci 2013; 9: 1057–1069.
Google Scholar |
Crossref |
Medline4.
Borghini, A, Manetti, M, Nacci, F, et al. Systemic sclerosis sera impair angiogenic performance of dermal microvascular endothelial cells: therapeutic implications of cyclophosphamide. PLoS ONE 2015; 10(6): e0130166.
Google Scholar |
Crossref5.
Altorok, N, Wang, YQ, Kahaleh, B. Endothelial dysfunction in systemic sclerosis. Curr Opin Rheumatol 2014; 26: 615–620.
Google Scholar |
Crossref |
Medline6.
Altorok, N, Almeshal, N, Wang, Y, et al. Epigenetics, the holy grail in the pathogenesis of systemic sclerosis. Rheumatology 2015; 54(10): 1759–1770.
Google Scholar |
Crossref |
Medline7.
Wang, Y, Fan, PS, Kahaleh, B. Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts. Arthritis Rheum 2006; 54(7): 2271–2279.
Google Scholar |
Crossref |
Medline8.
Wang, Y, Kahaleh, B. Epigenetic repression of bone morphogenetic protein receptor II expression in scleroderma. J Cell Mol Med 2013; 17(10): 1291–1299.
Google Scholar |
Crossref |
Medline9.
Altorok, N, Tsou, PS, Coit, P, et al. Genome-wide DNA methylation analysis in dermal fibroblasts from patients with diffuse and limited systemic sclerosis reveals common and subset-specific DNA methylation aberrancies. Ann Rheum Dis 2015; 74(8): 1612–1620.
Google Scholar |
Crossref |
Medline10.
Altorok, N, Nada, S, Kahaleh, B. The isolation and characterization of systemic sclerosis vascular smooth muscle cells: enhanced proliferation and apoptosis resistance. J Scleroderma Relat 2016; 1: 307–315.
Google Scholar |
SAGE Journals11.
Dennis, G, Sherman, BT, Hosack, DA, et al. DAVID: database for annotation, visualization, and integrated discovery. Genome Biology 2003; 4: P3.
Google Scholar |
Crossref |
Medline12.
Huang da, W, Sherman, BT, Lempicki, RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009; 4(1): 44–57.
Google Scholar |
Crossref |
Medline13.
Nada, SE, Thompson, RC, Padmanabhan, V. Developmental programming: differential effects of prenatal testosterone excess on insulin target tissues. Endocrinology 2010; 151(11): 5165–5173.
Google Scholar |
Crossref |
Medline14.
Ucuzian, AA, Gassman, AA, East, AT, et al. Molecular mediators of angiogenesis. J Burn Care Res 2010; 31: 158–175.
Google Scholar |
Crossref |
Medline15.
Felcht, M, Luck, R, Schering, A, et al. Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling. J Clin Invest 2012; 122(6): 1991–2005.
Google Scholar |
Crossref |
Medline16.
Daly, C, Pasnikowski, E, Burova, E, et al. Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells. Proc Natl Acad Sci U S A 2006; 103: 15491–15496.
Google Scholar |
Crossref |
Medline17.
Gale, NW, Thurston, G, Hackett, SF, et al. Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1. Dev Cell 2002; 3(3): 411–423.
Google Scholar |
Crossref |
Medline18.
Huang, H, Bhat, A, Woodnutt, G, et al. Targeting the ANGPT-TIE2 pathway in malignancy. Nat Rev Cancer 2010; 10(8): 575–585.
Google Scholar |
Crossref |
Medline19.
Miro, L, Perez-Bosque, A, Maijo, M, et al. Vasopressin regulation of epithelial colonic proliferation and permeability is mediated by pericryptal platelet-derived growth factor A. Exp Physiol 2014; 99(10): 1325–1334.
Google Scholar |
Crossref |
Medline20.
Heldin, CH, Westermark, B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev 1999; 79(4): 1283–1316.
Google Scholar |
Crossref |
Medline21.
Hoch, RV, Soriano, P. Roles of PDGF in animal development. Development 2003; 130(20): 4769–4784.
Google Scholar |
Crossref |
Medline22.
Andrae, J, Gallini, R, Betsholtz, C. Role of platelet-derived growth factors in physiology and medicine. Genes Develop 2008; 22: 1276–1312.
Google Scholar |
Crossref |
Medline23.
Forstermann, U, Gath, I, Schwarz, P, et al. Isoforms of nitric oxide synthase. Properties, cellular distribution and expressional control. Biochem Pharmacol 1995; 50: 1321–1332.
Google Scholar |
Crossref |
Medline24.
Palmer, RM, Ferrige, AG, Moncada, S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987; 327: 524–526.
Google Scholar |
Crossref |
Medline25.
Palmer, RM, Ashton, DS, Moncada, S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 1988; 333: 664–666.
Google Scholar |
Crossref |
Medline26.
Bredt, DS. Endogenous nitric oxide synthesis: biological functions and pathophysiology. Free Radic Res 1999; 31(6): 577–596.
Google Scholar |
Crossref |
Medline27.
Rapoport, RM, Draznin, MB, Murad, F. Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation. Nature 1983; 306: 174–176.
Google Scholar |
Crossref |
Medline28.
Forstermann, U, Sessa, WC. Nitric oxide synthases: regulation and function. European Heart J 2012; 33: 829–837; 837a.
Google Scholar |
Crossref |
Medline29.
Chang, CI, Liao, JC, Kuo, L. Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity. Cancer Research 2001; 61: 1100–1106.
Google Scholar |
Medline30.
Burnett, T, Pung, A, Bertram, JS, et al. The role of nitric oxide in neoplastic transformation of C3H 10T1/2 embryonic fibroblasts. Carcinogenesis 2000; 21(11): 1989–1995.
Google Scholar |
Crossref |
Medline31.
Kuo, MH, Allis, CD. Roles of histone acetyltransferases and deacetylases in gene regulation. Bioessays 1998; 20(8): 615–626.
Google Scholar |
Crossref |
Medline32.
Haberland, M, Montgomery, RL, Olson, EN. The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet 2009; 10(1): 32–42.
Google Scholar |
Crossref |
Medline33.
Wang, H, Lee, Y, Malbon, CC. PDE6 is an effector for the Wnt/Ca2+/cGMP-signalling pathway in development. Biochem Soc Trans 2004; 32(Pt5): 792–796.
Google Scholar |
Crossref |
Medline34.
Wang, HY, Malbon, CC. Wnt-frizzled signaling to G-protein-coupled effectors. Cell Mol Life Sci 2004; 61(1): 69–75.
Google Scholar |
Crossref |
Medline35.
Christodoulides, N, Durante, W, Kroll, MH, et al. Vascular smooth muscle cell heme oxygenases generate guanylyl cyclase-stimulatory carbon monoxide. Circulation 1995; 91: 2306–2309.
Google Scholar |
Crossref |
Medline36.
Cadigan, KM, Nusse, R. Wnt signaling: a common theme in animal development. Genes Develop 1997; 11: 3286–3305.
Google Scholar |
Crossref |
Medline37.
Gradl, D, Kuhl, M, Wedlich, D. The Wnt/Wg signal transducer beta-catenin controls fibronectin expression. Mol Cell Biol 1999; 19(8): 5576–5587.
Google Scholar |
Crossref |
Medline38.
Blavier, L, Lazaryev, A, Shi, XH, et al. Stromelysin-1 (MMP-3) is a target and a regulator of Wnt1-induced epithelial-mesenchymal transition (EMT). Cancer Biol Therap 2010; 10: 198–208.
Google Scholar |
Crossref |
Medline39.
Wu, BB, Crampton, SP, Hughes, CC. Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration. Immunity 2007; 26(2): 227–239.
Google Scholar |
Crossref |
Medline40.
Wei, J, Melichian, D, Komura, K, et al. Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy A novel mouse model for scleroderma. Arthritis Rheum 2011; 63(6): 1707–1717.
Google Scholar |
Crossref |
Medline41.
Lam, AP, Flozak, AS, Russell, S, et al. Nuclear beta-Catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation. Am J Resp Cell Mol 2011; 45: 915–922.
Google Scholar |
Crossref |
Medline42.
Bhattacharyya, S, Wei, J, Varga, J. Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities. Nat Rev Rheumatol 2012; 8: 42–54.
Google Scholar |
Crossref43.
Lampugnani, MG, Dejana, E. The control of endothelial cell functions by adherens junctions. Novartis Found Symp 2007; 283: 4–13; discussion 13.
Google Scholar |
Crossref |
Medline44.
Bajpai, S, Feng, YF, Krishnamurthy, R, et al. Loss of alpha-catenin decreases the strength of single E-cadherin bonds between human cancer cells. J Biol Chem 2009; 284: 18252–18259.
Google Scholar |
Crossref |
Medline45.
Song, X, He, X, Li, X, et al. The roles and functional mechanisms of interleukin-17 family cytokines in mucosal immunity. Cell Mol Immunol 2016; 13(4): 418–431.
Google Scholar |
Crossref |
Medline46.
Abraham, D, Distler, O. How does endothelial cell injury start? The role of endothelin in systemic sclerosis. Arthritis Res Ther 2007; 9(Suppl. 2): S2.
Google Scholar |
Crossref47.
Aggarwal, S, Gurney, AL. IL-17: prototype member of an emerging cytokine family. J Leukoc Biol 2002; 71(1): 1–8.
Google Scholar |
Medline48.
Xing, X, Yang, J, Yang, X, et al. IL-17A induces endothelial inflammation in systemic sclerosis via the ERK signaling pathway. PLoS ONE 2013; 8(12): e85032.
Google Scholar |
Crossref49.
Hasegawa, M, Asano, Y, Endo, H, et al. Serum adhesion molecule levels as prognostic markers in patients with early systemic sclerosis: a multicentre, prospective, observational study. PLoS ONE 2014; 9(2): 88150.
Google Scholar |
Crossref50.
Barnes, TC, Spiller, DG, Anderson, ME, et al. Endothelial activation and apoptosis mediated by neutrophil-dependent interleukin 6 trans-signalling: a novel target for systemic sclerosis. Ann Rheum Dis 2011; 70(2): 366–372.
Google Scholar |
Crossref |
Medline51.
Nomura, S, Inami, N, Ozaki, Y, et al. Significance of microparticles in progressive systemic sclerosis with interstitial pneumonia. Platelets 2008; 19(3): 192–198.
Google Scholar |
Crossref |
Medline52.
Hebbar, M, Gillot, JM, Hachulla, E, et al. Early expression of E-selectin, tumor necrosis factor alpha, and mast cell infiltration in the salivary glands of patients with systemic sclerosis. Arthritis Rheum 1996; 39(7): 1161–1165.
Google Scholar |
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