Post-operative endophthalmitis in immediate sequential bilateral cataract surgery A nation-wide registry study

Purpose

To report the incidence of post-operative endophthalmitis (PE) after immediate sequential bilateral cataract surgery (ISBCS) in Sweden.

Design

Retrospective cohort registry study.

Participants

Patient data from 1 457 172 cataract extractions including 1 364 934 unilateral surgeries and 92 238 ISBCS.

Methods

Endophthalmitis cases reported to the Swedish National Cataract Register (NCR) during a 16-year period (2002 – 2017) were analyzed in comparison to all control cases with regard to patient characteristics, surgical technique and capsule complication.

Main Outcome Measure

Incidence and determinants for PE in ISBCS compared to unilateral surgeries.

Results

A total of 422 cases of PE were identified in 1 457 172 cataract extractions, yielding an overall incidence of 0.029% [95% confidence interval (CI); 0.0262 - 0.0317]. For unilateral procedures, the rate was 0.0299% [95% CI; 0.0270 – 0.0328] or 408 cases in 1 364 934 operations, while that for ISBCS was 0.0152% [95% CI; 0.0072 – 0.0231] or 14 incidents in 92 238 operations, p = 0.01. In a logistic regression model including all cataract procedures, non-use of intracameral antibiotics, capsule complication, age 85 years or more, male gender and ocular comorbidity were found to be independent risk factors for PE. All these parameters were less frequent in ISBCS. Notwithstanding, in the same multivariate analysis ISBCS in itself was associated with a significantly lower risk for PE. At follow-up, 5 of the 14 PE cases in the ISBCS cohort had a visual acuity of 20/200 or worse. One 93-year-old ISBCS patient developed bilateral infection.

Conclusions

After ISBCS in Sweden, PE occurred once in 6 600 surgeries. The risk of sustaining a final visual acuity of 20/200 or less, was 1 incident in 18 000 operated eyes. When counselling potential ISBCS patients about the risk of PE, it seems reasonable to state that the reported risk in the literature is lower than that with unilateral surgery, but not negligible and precautions remain necessary.

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