Physiological significance of pre‐ and post‐ejection left ventricular tissue velocities and relations to mitral and aortic valve closures

Background

Tissue Doppler shows short-duration velocity spikes during pre- and post-ejection (protodiastole). They have been assumed to be isovolumic contraction and relaxation mobvements, but this is not in accordance with newer studies.

Methods

We examined 22 healthy volunteers. Valve closures and openings were determined from

spectral Doppler from LVOT and mitral inflow and transferred to colour tissue Doppler recordings for comparison with tissue velocities, colour M-mode and strain rate (SR).

Results

Pre-ejection positive velocity spikes were simultaneous in both walls, starting ca 24.8 ± 10.1 ms after start QRS, duration 51.5 ± 10.8 ms, ending 10.2 ± 11.5 ms after mitral valve closure (MVC) (p<0.001). There were corresponding colour tracings and negative strain rate. Protodiastolic lengthening was predominant in the septum. Negative velocity spikes had a duration of 35.5 ± 10.7 ms, ending 9.5 ± 14.7 ms after aortic valve closure (AVC, p<0.001) in septum. During isovolumic relaxation, strain rate showed apical lengthening (Peak SR – 0.72 ± 0.50 s-1) and basal shortening Peak SR 0.44 ± 0.63 s-1).

Conclusion

Electromechanical activation of the LV is simultaneous in septum and lateral wall, occurs before MVC, is terminated by MVC itself, and is thus not isovolumic. Protodiastole is a short event of lengthening, predominantly in the septum. It may be the mechanism for valve closure and ends by AVC itself. Isovolumic relaxation occurs after this velocity spike, and is characterized by elongation of the apex, shortening of the base, thus showing a volume shift from base towards apex.

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