Grant support: This research was supported by grants from the National Institutes of Health (P30 DK034987 (RSS), P30 DK52574 (NOD), P30 DK120531 (PM), P30DK123704 (DCR)

Disclosures: None of the authors have financial, professional or personal conflicts of interest to disclose relevant to this work.

Author contributions:

RSS: drafting manuscript, critical revision

NOD: drafting manuscript, critical revision

PM: drafting manuscript, critical revision

DCR: drafting manuscript, critical revision