Corresponding Author

The Center of Research & Development, Ruichuang Biotechnology Company, Qihang Building No.2, Keqiao Economic Development Zone, Shaoxing City, Zhejiang Province, China, 31200

Two authors contributed equally to this work.

To whom may be correspondent to: Shangzhi Xu, Ph.D., Liming Yang, M.D., Qihang Building No.2, Keqiao Economic Development Zone, Shaoxing City, Zhejiang Province, China 31200 Phone： 0575-81101509 Fax: 0575-81101721

Email: szxu@wyzebiotech.com

Likun Gong, Ph.D., is co-correspondent author, 501 Haike Road, Zhangjiaang Hi-Tech Park, Pudong, Shanghai City, China 201203

Email: lkungong@cdser.simm.ac.cn