This work was supported by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., NJ, USA. The funder of the study participated in development of the study design and funded the analysis of the data. All authors, including those employed by Merck, participated in the data interpretation and writing of the manuscript. Industrial partners supporting MelBase include Bristol-Myers Squibb, Roche, MSD, Amgen, and Novartis. E Casarotto was an employee of MSD France, Puteaux, France, at the time of this study. S Chandwani is an employee of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., NJ, USA and stockholder of Merck & Co., Inc., NJ, USA. L Mortier reports medical board membership and travel support from MSD, Roche, Bristol-Myers Squibb (BMS) and Novartis. C Dutriaux is clinical investigator, speaker or board participant for Novartis, BMS, MSD and Pierre Fabre. S Dalac reports honoraria from BMS, Novartis, MSD and Pierre Fabre; consultancy for BMS, Novartis and MSD; research funding support from BMS, Novartis and MSD; being on a speakers bureau for BMS; and travel and accommodations support from BMS. E Scherrer is an employee of MSD and stockholder of Merck & Co., Inc., NJ, USA; L Lévy-Bachelot, L Verdoni and G Farge are employees of MSD France, and L Lévy-Bachelot and L Verdoni are stockholders of Merck & Co., Inc., NJ, USA. C Allayous reports travel and accommodations support from Amgen, BMS and Roche. S Dalle reports institutional research grants from MSD, BMS and Roche; travel support from BMS, Pierre Fabre and MSD; and S Dalle spouse is an employee of Sanofi. C Lebbe reports honoraria from BMS, MSD, Novartis, Amgen, Roche, Pierre Fabre, Pfizer and Incyte; consultancy or advisory board membership for BMS, MSD, Novartis, Amgen, Roche and Avantis; being on a speakers bureau for BMS, Novartis, Amgen and Roche; research support received from Roche; travel and accommodations support from BMS, MSD. O Dereure and B Oriano report no relevant conflicts of interest. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Editorial assistance was provided by EV Hillyer, DVM (freelance). This assistance was funded by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., NJ, USA.