A new method for non-parametric multivariate analysis of variance.

Austral Ecology. 26: 32-46Bafeta A Yavchitz A Riveros C Batista R Ravaud P

Methods and reporting studies assessing fecal microbiota transplantation: a systematic review.

Annals of Internal Medicine. 167: 34-40

Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry.

Annu Rev Neurosci. 7: 309-338

Rostral ventromedial medulla control of spinal sensory processing in normal and pathophysiological states.

Neurosci. 147: 786-793Boyette-Davis J Dougherty PM

Protection against oxaliplatin-induced mechanical hyperalgesia and intraepidermal nerve fiber loss by minocycline.

Experimental Neurology. 229: 353-357Callahan BJ McMurdie PJ Rosen MJ Han AW Johnson AJ Holmes SP

DADA2: high-resolution sample inference from Illumina amplicon data.

Nature Methods. 13: 581-583

Neuroprotective effects of exercise on the morphology of somatic motoneurons following the death of neighboring motoneurons.

Neurorehabil Neural Repair. 33: 656-667

Microbiota-mediated mucosal inflammation in arthritis.

Best Practice & Research Clinical Rheumatology. 33: 1-12Cobos EJ Ghasemlou N Araldi D Segal D Duong K Woolf CJ

Inflammation-induced decrease in voluntary wheel running in mice: a non-reflexive test for evaluating inflammatory pain and analgesia.

Pain. 153: 876-884Coderre TJ Abbott FV Melzack R

Behavioral evidence in rats for a peptidergic-noradrenergic interaction in cutaneous sensory and vascular function.

Neuroscience Letters. 15: 113-118Cormier J Cone K Lanpher J Kinens A Henderson T Liaw L Bilsky EJ King T Rosen CJ Stevenson GW

Exercise reverses pain-related weight asymmetry and differentially modulates trabecular bone microarchitecture in a rat model of osteoarthritis.

Life Sciences. 180 (): 51-59

Craft RM: Modulation of pain by estrogens.

Pain. 132: S3-S12DeStefano IM Wayne AS Rozanski EA Babyak JM

Parenterally administered vancomycin in 29 dogs and 7 cats (2003 –2017).

Journal of Veterinary Internal Medicine. 33: 200-207Drennan PG Begg EJ Gardiner SJ Kirkpatrick CMJ Chambers ST

The dosing and monitoring of vancomycin: what is the best way forward?.

International Journal of Antimicrobial Agents. : 401-407Duman CH Schlesinger L Russell DS Duman RS

Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice.

Brain Research. 1199: 148-158

Vancomycin dosing and monitoring: critical evaluation of the current practice.

European Journal of Drug Metabolism and Pharmacokinetics. 43: 259-268Fillingim RB King CD Ribeiro-Dasilva MC Rahim-Williams B Riley JL

Sex, gender, and pain: a review of recent clinical and experimental findings.

The Journal of Pain. 10: 447-485Fonseca H Moreira-Goncalves D Esteves JL Viriato N Vaz M Mota MP Duarte JA

Voluntary exercise has long-term in vivo protective effects on osteocyte viability and bone strength following ovariectomy.

Calcif Tissue Int. 88: 443-454Gao H Shu Q Chen J Fan K Xu P Zhou Q Li C Zheng H

Antibiotic exposure has sex-dependent effects on the gut microbiota and metabolism of short-chain fatty acids and amino acids in mice.

mSystems. 4: :e00048-19Grace PM Fabisiak TJ Green-Fulgham SM Anderson ND Strand KA Kwilasz AJ Galer EL Walker FR Greenwood BN Maier SF Fleshner M Watkins LR

Prior wheel running attenuates neuropathic pain.

Pain. 157: 2012-2023Greenspan JD Craft RM LeResche L Arendt-Nielsen L Berkley KJ Fillingim RB Gold MS Holdcroft A Lautenbacher S Mayer EA Mogil JS Murphy AZ Traub RJ

Studying sex and gender differences in pain and analgesia: a consensus report.

Pain. 132: S26-S45Haak BW Lankelma JM Hugenholtz F Belzer C de Vos WM Wiersinga WJ

Long-term impact of oral vancomycin, ciprofloxacin and metronidazole on the gut microbiota in healthy humans.

Journal Antimicrobes and Chemotherapy. 74: 782-786Haskó G Kuhel DG Marton A Nemeth ZH Deitch EA Szabó C

Spermine differentially regulates the production of interleukin-12 p40 and interleukin-10 and suppresses the release of the T helper 1 cytokine interferon-gamma.

Shock Augusta Ga. 14: 144-149Hernandez G Mills TS Rabe JL Chavez JS Kuldanek S Kirkpatrick G Noetzli L Jubair WK Zanche M Myers JR Stevens BM Fleenor CJ Adane B Dinarello CA Ashton J Jordan CT Di Paola J Hagman JR Holers VM Kuhn KA Peitras EM

Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis.

Haematologica. 105: 585-597Hoban AE Moloney RD Golubeva AV McVey Neufeld KA O'Sullivan O Patterson E Stanton C dinan TG Clarke G Cryan JF

Behavioral and neurochemical consequences of chronic gut microbiota depletion during adulthood in the rat.

Neuroscience. 339: 463-477Hunskaar S Fasmer OB Hole K

Formalin test in mice, a useful technique for evaluating mild analgesics.

Journal of Neuroscience Methods. 14: 69-76Jubair WK Hendrickson JD Severs EL Schulz HM Adhikari S Ir D Pagan JD Anthony RM Robertson CE Frank DN Banda NK Kuhn KA

Modulation of inflammatory arthritis in mice by gut microbiota through mucosal inflammation and autoantibody generation.

Arthritis and Rheumatology. 70: 1220-1233Kandasamy R Calsbeek JJ Morgan MM

Home cage wheel running is an objective and clinically relevant method to assess inflammatory pain in male and female rats.

Journal of Neuroscience Methods. 263 ()Kandel ER Schwartz JH Jessel TM Siegelbaum SA Hudspeth AJ

Principles of Neural Science.

5th edn. McGraw Hill, NYKibe R Kurihara S Sakai Y Suzuki H Ooga T Sawaki E Muramatsu K Nakamura A Yamashita A Kitada Y Kakeyama M Benno Y Matsumoto M

Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice.

Science Reports. 4: 45-48Leung A Gregory NS Allen LA Sluka KA

Regular physical activity prevents chronic pain by altering resident muscle macrophage phenotype and increasing interleukin-10 in mice.

Pain. 157: 70-79Liu H Wang J He T Becker S Zhang G Li D Ma X

Butyrate: a double-edged sword for health?.

Advances in Nutrition. 9: 21-29Loftfield E Vogtmann E Sampson JN Moore SC Nelson H Knight R Chia N Sinha R

Comparison of collection methods for fecal samples for discovery metabolomics in epidemiologic studies.

Cancer Epidemiol. Biomarkers Prev. 25: 1483-1490

UniFrac: a new phylogenetic method for comparing microbial communities.

Applied Environmental Microbiology. 71: 8228-8235Lozupone CA Hamady M Kelley ST Knight R

Quantitative and qualitative beta diversity measures lead to different insights into factors that structure microbial communities.

Applied and Environmental Microbiology. 73: 1576-1585Martin CR Osadchiy V Kalani A Mayer EA

The brain-gut-microbiome axis.

Cellular and molecular gastroenterology and hepatology. 6: 133-148McDonald D Price MN Goodrich J Nawrocki EP DeSantis TZ Probst A Andersen GL Knight R Hugenholtz P

An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea.

The ISME Journal. 6: 610-618Mcgaha TL Huang L Lemos H Metz R Mautino M Prendergast GC Mellor AL

Amino acid catabolism: a pivotal regulator of innate and adaptive immunity.

Immunology Reviews. 249: 135-157Miller LL Picker MJ Schmidt KT Dykstra LA

Effects of morphine on pain-elicited and pain-suppressed behavior in CB1 knockout and wildtype mice.

Psychopharmacology. 215: 455-465

Effect size, confidence interval and statistical significance: a practical guide for biologists.

Biol. Rev. 82: 591-605

National Research Council. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research, Washington, DC, 2003

Negus SS Vanderah TW Brandt MR Bilsky EJ Becerra L Borsook D

Preclinical assessment of candidate analgesic drugs: recent advances and future challenges.

Journal of Pharmacology and Experimental Therapeutics. 319: 507-514

Core outcome measures in preclinical assessment of candidate analgesics.

Pharmacological Reviews. 71: 225-266Nieuwenhuis EES Visser MR Kavelaars A Cobelens PM Fleer A Harmsen W Verhoef J Akkermans LMA Heijnen CJ.

Oral antibiotics as a novel therapy for arthritis.

Arthritis & Rheumatism. 43: 2583-2589Ni J Shen T-CD Chen EZ Bittinger K Bailey A Roggiani M Sirota-Madi A Friedman ES Chau L Lin A Nissim I Scott J Lauder A Hoffman C Rivas G Albenberg L Baldassano RN Braun J Xavier RJ Clish CB Yudkoff M Li H Goulian M Bushman FD Lewis JD Wu GD

A role for bacterial urease in gut dysbiosis and Crohn's disease.

Science Translational Medicine. 9: eaah6888

NIH Policy on Sex as a Biological Variable. National Institutes of Health, Office of Research on Women's Health, searched on 9-27-20. https://orwh.od.nih.gov/sex-gender/nih-policy-sex-biological-variable

O'Mahony SM Felice VD Nally K Savignac HM Claesson MJ Scully P Woznicki J Hyland NP Shanahan F Quigley EM Marchesi JR O'Toole PW Dinan TG Cryan JF

Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive or anxiety-related behaviors in male rats.

Neuroscience. 277: 885-901Oliphant K Allen-Vercoe E

Macronutrient metabolism by the human gut microbiome: major fermentation by-products and their impact on host health.

Microbiome. 7: 1-15Ossipov MH Lai J Malan Jr TP Porreca F

Spinal and supraspinal mechanisms of neuropathic pain.

Ann NY Acad Sci. 909: 12-24Patten AR Sickmann H Hryciw BN Kucharsky T Parton R Kernick A Christie BR

Long-term exercise is needed to enhance synaptic plasticity in the hippocampus.

Cold Spring Harbor Laboratory Press. 20: 642-647Picchianti-Diamanti A Rosado MM D'Amelio R

Infectious agents and inflammation: the role of microbiota in autoimmune arthritis.

Frontiers in Microbiology. 8: 1-9Portune KJ Beaumont M Davila A-M Tomé D Blachier F Sanz Y

Gut microbiota role in dietary protein metabolism and helath-related outcomes: the two sides of the coin.

Trends in Food Sciences Technology. 57: 213-232Rakoff-Nahoum S Paglino J Eslami-Varzaneh F Edberg S Medzhitov R

Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis.

Cell. 118: 229-241Reikvam DH Erofeev A Sandvik A Grcic V Jahnsen FL Gaustad P McCoy KD Macpherson AJ Meza-Zepeda LA Johansen F-E

Depletion of murine intestinal microbiota: effects on gut mucosa and epithelial gene expression.

PLoS ONE. 6: e17996Ren M Zhang SH Zeng XF Liu H Qiao SY

Branched-chain amino acids are beneficial to maintain growth performance and intestinal immune-related function in weaned piglets fed protein restricted diet.

Asian-Australian Journal of Animal Science. 28: 1742-1750Ren M Zhang S Liu X Li S Mao X Zeng X Qiao S

Different lipopolysaccharide branched-chain amino acids modulate porcine intestinal endogenous β-defensin expression through the Sirt1 /ERK / 90RSK pathway.

Journal of Agricultural and Food Chemistry. 64: 337-3379

Roles for intestinal bacteria, viruses, and fungi in pathogenesis of inflammatory bowel diseases and therapeutic approaches.

Gastroenterology. 152: 327-339Seifert HA Benedek G Nguyen H Gerstner G Zhang Y Kent G Vandenbark AA Bernhagen J Offner H

Antibiotics protect against EAE by increasing regulatory and anti-inflammatory cells.

Metabolic Brain Disease. 33: 1599-1607Shen S Lim G You Z Ding W Huang P Ran C Doheny J Caravan P Tate S Hu K Kim H McCabe M Huang B Xie Z Kwon D Chen L Mao J

Gut microbiota is critical for the induction of chemotherapy-induced pain.

Nature Neuroscience. 20: 1213-1216Shen TC Albenberg L Bittinger K Chehoud C Chen YY Judge CA Chau L Ni J Sheng M Lin A Wilkins BJ Buza EL Lewis JD Saikhin Y Nissim I Yudkoff M Bushman FD Wu GD

Engineering the gut microbiota to treat hyperammonemia.

The Journal of Clinical Investigation. 125: 2841-2850Sherwin E Sandhu KV Dinan TG Cryan JF

May the force be with you: the light and dark sides of the microbiota-gut-brain axis in neuropsychiatry.

CNS Drugs. 30: 1019-1041Singh V Yeoh BS Abokor AA Golonka RM Tian Y Patterson AD Joe B Heikenwalder M Vijay-Kumar M

Vancomycin prevents fermentable fiber-induced liver cancer in mice with dysbiotic gut microbiota.

Gut Microbes. 11: 1077-1091

Wheel running decreases the positive reinforcing effects of heroin.

Pharmacology Reports. 64: 960-964Song SJ Amir A Metcalf JL Amato KR Xu ZZ Humphrey G Knight R

Preservation methods differ in fecal microbiome stability, affecting suitability for field studies.

mSystems. 1 ()Stevenson GW Bilsky EJ Negus SS

Targeting pain-suppressed behaviors in preclinical assays of pain and analgesia: effects of morphine on acetic acid-suppressed feeding in C57BL/6J mice.

The Journal of Pain. 6: 408-416Stevenson GW Mercer M Cormier J Dunbar C Benoit L Adams C Jezierski J Luginbuhl A Bilsky EJ

Monosodium iodoacetate-induced osteoarthritis produces pain-depressed wheel running in rats: implications for preclinical behavioral assessment of chronic pain.

Pharmacology, Biochemistry and Behavior. 98: 35-42Tanes C Bittinger K Gao Y Friedman ES Nessel L Paladhi UR Chau L Panfen E Fischbach MA Braun J Xavier RJ Clish CB Li H Bushman FD Lewis JD Wu GD

Role of dietary fiber in the recovery of the human gut microbiome and its metabolome.

Cell Host Microbe. ()Tappe-Theodor A King T Morgan MM

Pros and cons of clinically relevant methods to assess pain in rodents.

Neuroscience and Biobehavioral Reviews. 100: 335-343Thompson RS Roller R Greenwood BN Fleshner M

Wheel running improves REM sleep and attenuates stress-induced flattening of diurnal rhythms in F344 rats.

Stress. 19: 312-324Uribe-Herranz M Bittinger K Rafail S Guedan S Pierini S Tanes C Ganetsky A Morgan MA Gill S Tanyi JL Bushman FD June CH Facciabene A

Gut microbiota modulates adoptive cell therapy via CD8α dendritic cells and IL-12.

JCI Insight. 3: e94952Valdes C Bustos G Martinez JL Laurido C

Antinociceptive antibiotic-loaded into solid lipid nanoparticles of prolonged release: measuring pharmacological efficiency and time span on chronic monoarthritis rats.

PLoS ONE. 13e0187473Vogtmann E Chen J Amir A Shi J Abnet CC Nelson H Knight R Chia N Sinha R

Comparison of collection methods for fecal samples in microbiome studies.

Am J. Epidemiol. 185: 115-123Waineo MF Kuhn TC Brown DL

The pharmacokinetic/pharmacodynamic rationale for administering vancomycin via continuous infusion.

Journal of Clinical Pharmacy and Therapeutics. 40: 259-265

Intestinal microbiota, fecal microbiota transplantation, and inflammatory bowel disease.

Gut Microbes. 8: 238-252

Wilson DB: Meta-analysis macros for SAS, SPSS, and Stata, and effect size calculator. Retrieved from http://mason.gmu.edu/∼dwilsonb/ma.html 2004

Functional amino acids in nutrition and health.

Amino Acids. 45: 407-411

Review article: insights into colonic protein fermentation, its modulation and potential health implications.

Ailment Pharmacol Ther. 43: 181-196Zidon TM Park WM Welly RJ Woodford ML Scroggins RJ Britton SL Koch LG Booth FW Padilla J Kanaley JA Vieira-Potter VJ

Voluntary wheel running improves adipose tissue immunometabolism in ovariectomized low-fit rats.

Adipocyte. 7: 20-34