Chou R, Cantor A, Dana T et al (2022) Statin use for the primary Prevention of Cardiovascular Disease in adults. JAMA 328:754

Article  PubMed  Google Scholar 

Amarenco P, Labreuche J (2009) Lipid management in the prevention of stroke: review and updated meta-analysis of statins for stroke prevention. Lancet Neurol 8:453–463

Article  PubMed  CAS  Google Scholar 

Grundy SM, Stone NJ, Bailey AL, AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA et al (2018) /ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: Executive Summary. J Am Coll Cardiol 2019; 73: 3168–3209

Mach F, Baigent C, Catapano AL et al (2020) 2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J 41:111–188

Article  PubMed  Google Scholar 

Kleindorfer DO, Towfighi A, Chaturvedi S et al 2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline From the American Heart Association/American Stroke Association. Stroke; 52. Epub ahead of print July 2021. https://doi.org/10.1161/STR.0000000000000375

Lee M, Cheng C-Y, Wu Y-L et al (2022) Association between Intensity of Low-Density Lipoprotein Cholesterol reduction with statin-based therapies and secondary Stroke Prevention. JAMA Neurol 79:349

Article  PubMed  PubMed Central  Google Scholar 

Nelson AJ, Haynes K, Shambhu S et al (2022) High-intensity statin use among patients with atherosclerosis in the U.S. J Am Coll Cardiol 79:1802–1813

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ray KK, Molemans B, Schoonen WM et al (2021) EU-Wide cross-sectional observational study of lipid-modifying therapy use in secondary and primary care: the DA VINCI study. Eur J Prev Cardiol 28:1279–1289

Article  PubMed  Google Scholar 

Yao X, Shah ND, Gersh BJ et al (2020) Assessment of trends in Statin Therapy for Secondary Prevention of Atherosclerotic Cardiovascular Disease in US adults from 2007 to 2016. JAMA Netw Open 3:e2025505

Article  PubMed  PubMed Central  Google Scholar 

Canavero I, Cavallini A, Perrone P et al (2014) Clinical factors associated with statins prescription in acute ischemic stroke patients: findings from the Lombardia Stroke Registry. BMC Neurol 14:53

Article  PubMed  PubMed Central  Google Scholar 

Yang Z, Edwards D, Massou E et al (2019) Statin use and high-dose statin use after ischemic stroke in the UK: a retrospective cohort study. Clin Epidemiol 11:495–508

Article  PubMed  PubMed Central  Google Scholar 

Adams HP, Bendixen BH, Kappelle LJ et al (1993) Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 24:35–41

Article  PubMed  Google Scholar 

Hackam DG, Hegele RA (2019) Cholesterol lowering and Prevention of Stroke. Stroke 50:537–541

Article  PubMed  Google Scholar 

Yaghi S, Elkind MSV (2015) Lipids and cerebrovascular disease. Stroke 46:3322–3328

Article  PubMed  PubMed Central  Google Scholar 

Baigent C, Blackwell L, Emberson J et al (2010) Cholesterol treatment trialists’ (CTT) collaboration. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials. Lancet 376:1670–1681

Article  PubMed  CAS  Google Scholar 

Amarenco P, Bogousslavsky J, Callahan A III et al (2006) High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med 355:549–559

Article  PubMed  CAS  Google Scholar 

Amarenco P, Benavente O, Goldstein LB et al (2009) Results of the Stroke Prevention by Aggressive reduction in cholesterol levels (SPARCL) trial by stroke subtypes. Stroke 40:1405–1409

Article  PubMed  CAS  Google Scholar 

Amarenco P, Kim JS, Labreuche J et al (2020) A comparison of two LDL cholesterol targets after ischemic stroke. N Engl J Med 382:9–19

Article  PubMed  CAS  Google Scholar 

Bach F, Skajaa N, Esen BÖ et al (2023) High-intensity versus moderate-intensity statin treatment for patients with ischemic stroke: nationwide cohort study. Eur Stroke J 8:1041–1052

Article  PubMed  PubMed Central  Google Scholar 

Kytö V, Åivo J, Ruuskanen JO (2024) Intensity of statin therapy after ischaemic stroke and long-term outcomes: a nationwide cohort study. Stroke Vasc Neurol; svn-2024-003230.

Dearborn-Tomazos JL, Hu X, Bravata DM et al (2021) Deintensification or no statin treatment is Associated with higher mortality in patients with ischemic stroke or transient ischemic attack. Stroke 52:2521–2529

Article  PubMed  CAS  Google Scholar 

Amarenco P, Kim JS, Labreuche J et al (2022) Yield of dual therapy with statin and ezetimibe in the treat stroke to Target Trial. Stroke 53:3260–3267

Article  PubMed  CAS  Google Scholar 

Åivo J, Ruuskanen JO, Tornio A et al (2023) Lack of statin therapy and outcomes after ischemic stroke: a Population-based study. Stroke 54:781–790

Article  PubMed  PubMed Central  Google Scholar 

Kim JS (2021) Role of blood lipid levels and lipid-lowering therapy in Stroke patients with different levels of cerebral artery diseases: reconsidering recent stroke guidelines. J Stroke 23:149–161

Article  PubMed  PubMed Central  Google Scholar 

Goldstein LB, Amarenco P, Szarek M et al (2008) Hemorrhagic stroke in the Stroke Prevention by Aggressive reduction in cholesterol levels study. Neurology 70:2364–2370

Article  PubMed  CAS  Google Scholar 

Endres M, Nolte CH, Scheitz JF (2018) Statin treatment in patients with Intracerebral Hemorrhage. Stroke 49:240–246

Article  PubMed  Google Scholar 

Choi K, Seo W, Park M et al Effect of statin therapy on outcomes of patients with Acute Ischemic Stroke and Atrial Fibrillation. J Am Heart Assoc. 2019;8(24):e013941. https://doi.org/10.1161/JAHA.119.013941

Park H-K, Lee JS, Hong K-S et al Statin therapy in acute cardioembolic stroke with no guidance-based indication. Neurology. 2020;94(19):e1984–e1995. https://doi.org/10.1212/WNL.0000000000009397

Violi F, Calvieri C, Ferro D et al (2013) Statins as Antithrombotic Drugs Circulation 127:251–257

PubMed  Google Scholar 

Cappellari M, Bovi P, Moretto G et al (2013) The THRombolysis and STatins (THRaST) study. Neurology 80:655–661

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sung EM, Saver JL (2024) Statin overuse in cerebral ischemia without indications: systematic review and Annual US Burden of adverse events. Stroke 55:2022–2033

Article  PubMed  Google Scholar 

Armitage J, Baigent C, Barnes E et al (2019) Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials. Lancet 393:407–415

Article  Google Scholar 

Virani SS, Woodard LD, Ramsey DJ et al (2015) Gender disparities in evidence-based statin therapy in patients with Cardiovascular Disease. Am J Cardiol 115:21–26

Article  PubMed  Google Scholar 

Mansoor H, Manion D, Kucharska-Newton A et al Sex differences in prescription patterns and Medication Adherence to Guideline-directed medical therapy among patients with ischemic stroke. Stroke. Epub ahead of print October 2024. https://doi.org/10.1161/STROKEAHA.124.048058

Ray KK, Haq I, Bilitou A et al (2023) Treatment gaps in the implementation of LDL cholesterol control among high- and very high-risk patients in Europe between 2020 and 2021: the multinational observational SANTORINI study. Lancet Reg Health - Europe 29:100624

Article  PubMed  Google Scholar