Introduction: Dengue fever is one of the most common vector-borne diseases in the world, affecting many people annually and causing many deaths. Besides, treating this disease is difficult, and there is no effective vaccine for it. In recent years, attention has been paid to the role of micronutrients, including vitamin D, in the control and treatment of viral diseases, including dengue fever. Accordingly, this study aimed to investigate the role of vitamin D in the treatment and control of dengue fever worldwide using a systematic review method. Methods: This study was conducted as a systematic review of the role of vitamin D in the prevention and control of dengue fever globally using a systematic review method. Therefore, all relevant articles were extracted and reviewed through a search in the international scientific databases, including PubMed/MEDLINE, WEB OF Science (ISI), and SCOPUS, without a time limit until the end of 2024. The quality of the articles was assessed using the STROB checklist. Results: Six articles published between 2018 and 2023 were included in the systematic review process. According to the findings, vitamin D affects macrophages that are differentiated from monocytes and increases resistance to dengue virus. Vitamin D also reduces pro-inflammatory cytokines, transcription, and reduction of mRNA receptors, increases the production of interleukins, especially IL-10, and plays a role in reducing viral load, severity of clinical symptoms, and infection control. Conclusion: Vitamin D3 can control the disease and decrease viral load and the severity of dengue fever in patients by inhibiting the inflammatory response and enhancing the immune response. However, given the limited number of studies, it is recommended that more studies be conducted in this field so that this can be discussed with more evidence and accuracy. Keywords: Dengue virus, vitamin D, vectors, systematic review

The authors have declared no competing interest.

This study did not receive any funding

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