Front. Surg.

Sec. Thoracic Surgery

Volume 11 - 2024 | doi: 10.3389/fsurg.2024.1506850

This article is part of the Research Topic Clinical and Surgical Perspectives in Sublobar Resection for Lung Cancer View all articles

Provisionally accepted

Yuanyuan Xiao 1 Wei Chen 2* Shancheng He 1* Baochang Xie 1* Wenqi Zhao 1* Yuhui Xu 3* 1 Ganzhou Fifth People's Hospital, Ganzhou, China 2 Jiangxi Changzheng Hospital, Ganzhou, China 3 Ganzhou People's Hospital, Ganzhou, Jiangxi Province, China

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Objective: Lung cancer is the leading cause of cancer-related mortality. Lymph node involvement remains a crucial prognostic factor in non-small cell lung cancer (NSCLC), and the TNM system is the current standard for staging. However, it mainly considers the anatomical location of lymph nodes, neglecting the significance of node count. Metrics like metastatic lymph node count and lymph node ratio (LNR) have been proposed as more accurate predictors.We used data from the SEER 17 Registry Database (2010-2019), including 52,790 NSCLC patients who underwent lobectomy or pneumonectomy, with at least one lymph node examined. Primary outcomes were overall survival (OS) and cancer-specific survival (CSS). Cox regression models assessed the prognostic value of negative lymph node (NLN) count, number of positive lymph node (NPLN), and LNR, with cut-points determined using X-tile software. Model performance was evaluated by the Akaike information criterion (AIC).The Cox proportional hazards model analysis revealed that NLN, NPLN, and LNR are independent prognostic factors for OS and LCSS (P

Keywords: prognostication, negative lymph node, Survival, NSCLC, SEER

Received: 06 Oct 2024; Accepted: 25 Nov 2024.

Copyright: © 2024 Xiao, Chen, He, Xie, Zhao and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Wei Chen, Jiangxi Changzheng Hospital, Ganzhou, China
Shancheng He, Ganzhou Fifth People's Hospital, Ganzhou, China
Baochang Xie, Ganzhou Fifth People's Hospital, Ganzhou, China
Wenqi Zhao, Ganzhou Fifth People's Hospital, Ganzhou, China
Yuhui Xu, Ganzhou People's Hospital, Ganzhou, Jiangxi Province, China

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