This study followed the tenets of the Declaration of Helsinki and was approved by the Ethics Committee of the Tohoku University School of Medicine. Written informed consent was obtained from all participants at the time of sample collection. The investigator, Dr. Tatsu Okabe, had full access to all the data in the study. No authors have any potential conflicts of interest to disclose. This paper was supported by JST grants from JSPS KAKENHI Grants-in-Aid for Scientific Research (C) (H.K. 17K11445 and M.Y. 23K09055) and COI-NEXT (JPMJPF2201). The funders had no role in the design or conduct of the study; collection, management, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; or the decision to submit the manuscript for publication.