Aicale R, Tarantino D, Maccauro G, Peretti G, Maffulli N. Genetics in orthopaedic practice. J Biol REGULATORS Homeost AGENTS. 2019;33(1):103–17.

CAS  Google Scholar 

Kambouris M, Del Buono A, Maffulli N. Genomics DNA profiling in elite professional soccer players: a pilot study. Translational Medicine@ UniSa. 2014;9:18.

CAS  PubMed  Google Scholar 

Kambouris M, Ntalouka F, Ziogas G, Maffulli N. Predictive genomics DNA profiling for athletic performance. Recent Pat DNA Gene Sequences (Discontinued). 2012;6(3):229–39.

Article  CAS  Google Scholar 

Cecconi M, Evans L, Levy M, Rhodes A. Sepsis and septic shock. Lancet. 2018;392(10141):75–87.

Article  PubMed  Google Scholar 

Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, Colombara DV, Ikuta KS, Kissoon N, Finfer S, et al. Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the global burden of Disease Study. Lancet. 2020;395(10219):200–11.

Article  PubMed  PubMed Central  Google Scholar 

Vincent JL. Increasing awareness of sepsis: World Sepsis Day. Crit Care. 2012;16(5):152.

Article  PubMed  PubMed Central  Google Scholar 

Fleischmann C, Scherag A, Adhikari NK, Hartog CS, Tsaganos T, Schlattmann P, Angus DC, Reinhart K. International Forum of Acute Care T: Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current estimates and limitations. Am J Respir Crit Care Med. 2016;193(3):259–72.

Article  CAS  PubMed  Google Scholar 

Tiru B, DiNino EK, Orenstein A, Mailloux PT, Pesaturo A, Gupta A, McGee WT. The economic and humanistic burden of severe Sepsis. PharmacoEconomics. 2015;33(9):925–37.

Article  PubMed  Google Scholar 

Lu Y, Chen W, Guo Y, Wang Y, Wang L, Zhang Y. Risk factors for short-term mortality in elderly hip fracture patients with complicated heart failure in the ICU: a MIMIC-IV database analysis using nomogram. J Orthop Surg Res. 2023;18(1):829.

Article  PubMed  PubMed Central  Google Scholar 

Thorkildsen MS, Gustad LT, Mohus RM, Burgess S, Nilsen TIL, Damas JK, Rogne T. Association of genetically predicted Insomnia with Risk of Sepsis: a mendelian randomization study. JAMA Psychiatry. 2023;80(10):1061–5.

Article  PubMed  PubMed Central  Google Scholar 

Lafuente Cabrero E, Terradas Robledo R, Civit Cunado A, Garcia Sardelli D, Hidalgo Lopez C, Giro Formatger D, Lacueva Perez L, Esquinas Lopez C, Tortosa Moreno A. Risk factors of catheter- associated bloodstream infection: systematic review and meta-analysis. PLoS ONE. 2023;18(3):e0282290.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ponsford MJ, Gkatzionis A, Walker VM, Grant AJ, Wootton RE, Moore LSP, Fatumo S, Mason AM, Zuber V, Willer C, et al. Cardiometabolic traits, Sepsis, and severe COVID-19: a mendelian randomization investigation. Circulation. 2020;142(18):1791–3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Z, Wang Z. The role of macrophages polarization in sepsis-induced acute lung injury. Front Immunol. 2023;14:1209438.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wong CK, McLean BA, Baggio LL, Koehler JA, Hammoud R, Rittig N, Yabut JM, Seeley RJ, Brown TJ, Drucker DJ. Central glucagon-like peptide 1 receptor activation inhibits toll-like receptor agonist-induced inflammation. Cell Metab. 2024;36(1):130–e143135.

Article  CAS  PubMed  Google Scholar 

Chen X, Liu Y, Gao Y, Shou S, Chai Y. The roles of macrophage polarization in the host immune response to sepsis. Int Immunopharmacol. 2021;96:107791.

Article  CAS  PubMed  Google Scholar 

Wang L, Huang J, Jiang M, Lin H. Tissue-specific transplantation antigen P35B (TSTA3) immune response-mediated metabolism coupling cell cycle to postreplication repair network in no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) by biocomputation. Immunol Res. 2012;52(3):258–68.

Article  CAS  PubMed  Google Scholar 

Matsushima K, Yang D, Oppenheim JJ. Interleukin-8: an evolving chemokine. Cytokine. 2022;153:155828.

Article  CAS  PubMed  Google Scholar 

Dumont RA, Car BD, Voitenok NN, Junker U, Moser B, Zak O, O’Reilly T. Systemic neutralization of interleukin-8 markedly reduces neutrophilic pleocytosis during experimental lipopolysaccharide-induced meningitis in rabbits. Infect Immun. 2000;68(10):5756–63.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gonzalez-Aparicio M, Alfaro C. Significance of the IL-8 pathway for immunotherapy. Hum Vaccin Immunother. 2020;16(10):2312–7.

Article  CAS  PubMed  Google Scholar 

Baldini C, Danlos FX, Varga A, Texier M, Halse H, Mouraud S, Cassard L, Champiat S, Signolle N, Vuagnat P, et al. Safety, recommended dose, efficacy and immune correlates for nintedanib in combination with pembrolizumab in patients with advanced cancers. J Exp Clin Cancer Res. 2022;41(1):217.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pavlakovic H, Havers W, Schweigerer L. Multiple angiogenesis stimulators in a single malignancy: implications for anti-angiogenic tumour therapy. Angiogenesis. 2001;4(4):259–62.

Article  CAS  PubMed  Google Scholar 

Rautiainen L, Cirko A, Pavare J, Grope I, Gersone G, Tretjakovs P, Gardovska D. Biomarker combinations in predicting sepsis in hospitalized children with fever. BMC Pediatr. 2022;22(1):272.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Macdonald SP, Stone SF, Neil CL, van Eeden PE, Fatovich DM, Arendts G, Brown SG. Sustained elevation of resistin, NGAL and IL-8 are associated with severe sepsis/septic shock in the emergency department. PLoS ONE. 2014;9(10):e110678.

Article  PubMed  PubMed Central  Google Scholar 

Zhao XF, Zhu SY, Hu H, He CL, Zhang Y, Li YF, Wu YQ. [Association between interleukin-8 rs4073 polymorphisms and susceptibility to neonatal sepsis]. Zhongguo Dang Dai Er Ke Za Zhi. 2020;22(4):323–7.

PubMed  Google Scholar 

Fu P, Xie S, Zhang X. IL-8 gene locus is associated with risk, severity and 28-day mortality of sepsis in a Chinese population. Clin Exp Med. 2019;19(4):571–6.

Article  PubMed  Google Scholar 

Artells R, Pruna R, Dellal A, Maffulli N. Elastin: a possible genetic biomarker for more severe ligament injuries in elite soccer. A pilot study. Muscles Ligaments Tendons J. 2016;6(2):188.

Article  PubMed  PubMed Central  Google Scholar 

Pruna R, Artells R, Lundblad M, Maffulli N. Genetic biomarkers in non-contact muscle injuries in elite soccer players. Knee Surg Sports Traumatol Arthrosc. 2017;25:3311–8.

Article  PubMed  Google Scholar 

Giuseppe Longo U, Loppini M, Margiotti K, Salvatore G, Berton A, Khan S, Maffulli W, Denaro N. Unravelling the genetic susceptibility to develop ligament and tendon injuries. Curr Stem Cell Res Therapy. 2015;10(1):56–63.

Article  Google Scholar 

Weinberg DS, Narayanan AS, Moore TA, Vallier HA. Prolonged resuscitation of metabolic acidosis after trauma is associated with more complications. J Orthop Surg Res. 2015;10:153.

Article  PubMed  PubMed Central  Google Scholar 

Peng Q, Qin X, He Y, Chen Z, Deng Y, Li T, Xie L, Zhao J, Li S. Association of IL27 gene polymorphisms and HBV-related hepatocellular carcinoma risk in a Chinese population. Infect Genet Evol. 2013;16:1–4.

Article  CAS  PubMed  Google Scholar 

Qin X, Peng Q, Lao X, Chen Z, Lu Y, Lao X, Mo C, Sui J, Wu J, Zhai L, et al. The association of interleukin-16 gene polymorphisms with IL-16 serum levels and risk of nasopharyngeal carcinoma in a Chinese population. Tumour Biol. 2014;35(3):1917–24.

Article  CAS