Fahy JV, Dickey BF. Airway mucus function and dysfunction. N Engl J Med. 2010;363:2233–47.
Article PubMed PubMed Central CAS Google Scholar
King M. Physiology of mucus clearance. Paediatr Respir Rev. 2006;7:S212–4.
Rogers DF. Overview of Airway Mucus Clearance. In: Rubin BK, van der Schans CP, eds. Therapy for Mucus-Clearance Disorders. Marcel Dekker: New York, NY, 2004, pp 1–27.
Ma J, Rubin BK, Voynow JA. Mucins, Mucus, and Goblet Cells. Chest. 2018;154:169–76.
King M. Mucolytics and Mucus Clearance. In: Rubin BK, van der Schans CP, editors. Therapy for Mucus-Clearance Disorders. Marcel Dekker: New York, NY, 2004, pp 201–24.
Rubin BK. Mucus and mucins. Otolaryngol Clin North Am. 2010;43:27–34.
Openshaw P, Edwards S, Helms P. Changes in rib cage geometry during childhood. Thorax. 1984;39:624–7.
Article PubMed PubMed Central CAS Google Scholar
Mortola JP. Chest wall mechanics in newborns. In: Roussos C, editor. The Thorax, 2 edn, vol. A. Dekker, M: New York, NY, 1995, pp 617–31.
Knill R, Andrews W, Bryan AC, Bryan MH. Respiratory load compensation in infants. J Appl Physiol. 1976;40:357–61.
Article PubMed CAS Google Scholar
Davi M, Sankaran K, Maccallum M, Cates D, Rigatto H. Effect of sleep state on chest distortion and on the ventilatory response to CO2 in neonates. Pediatr Res. 1979;13:982–6.
Article PubMed CAS Google Scholar
Papastamelos C, Panitch HB, England SE, Allen JL. Developmental changes in chest wall compliance in infancy and early childhood. J Appl Physiol. 1995;78:179–84.
Article PubMed CAS Google Scholar
Stocks JM, Hislop AA. Structure and function of the respiratory system: developmental aspects and their relevance to aersol therapy. In: Bisgaard H, O’Callaghan C, Smaldone GC, editors. Drug Delivery to the Lung. Marcel Dekker: New York, NY, 2002, pp 47–104.
Kosch PC, Stark AR. Dynamic maintenance of end-expiratory lung volume in full-term infants. J Appl Physiol Respir Environ Exerc Physiol. 1984;57:1126–33.
Hislop AA, Haworth SG. Airway size and structure in the normal fetal and infant lung and the effect of premature delivery and artificial ventilation. Am Rev Respir Dis. 1989;140:1717–26.
Article PubMed CAS Google Scholar
Rodenstein DO, Perlmutter N, Stanescu DC. Infants are not obligatory nasal breathers. Am Rev Respir Dis. 1985;131:343–7.
Chua HL, Collis GG, Newbury AM, Chan K, Bower GD, Sly PD, et al. The influence of age on aerosol deposition in children with cystic fibrosis. Eur Respir J. 1994;7:2185–91.
Article PubMed CAS Google Scholar
Wolfsdorf J, Swift DL, Avery ME. Mist therapy reconsidered; an evaluation of the respiratory deposition of labelled water aerosols produced by jet and ultrasonic nebulizers. Pediatrics. 1969;43:799–808.
Article PubMed CAS Google Scholar
Salmon B, Wilson NM, Silverman M. How much aerosol reaches the lungs of wheezy infants and toddlers? Arch Dis Child. 1990;65:401–3.
Article PubMed PubMed Central CAS Google Scholar
Bianco F, Salomone F, Milesi I, Murgia X, Bonelli S, Pasini E, et al. Aerosol drug delivery to spontaneously-breathing preterm neonates: lessons learned. Respir Res. 2021;22:71.
Article PubMed PubMed Central Google Scholar
Numa AH, Newth CJ. Anatomic dead space in infants and children. J Appl Physiol. 1996;80:1485–9.
Article PubMed CAS Google Scholar
Diot P, Palmer LB, Smaldone A, DeCelie-Germana J, Grimson R, Smaldone GC. RhDNase I aerosol deposition and related factors in cystic fibrosis. Am J Respir Crit Care Med. 1997;156:1662–8.
Article PubMed CAS Google Scholar
Collis GG, Cole CH, Le Souef PN. Dilution of nebulised aerosols by air entrainment in children. Lancet. 1990;336:341–3.
Article PubMed CAS Google Scholar
Abman SH, Collaco JM, Shepherd EG, Keszler M, Cuevas-Guaman M, Welty SE, et al. Interdisciplinary Care of Children with Severe Bronchopulmonary Dysplasia. J Pediatr. 2017;181:12–28.e11.
Baker CD. Long-term ventilation for children with chronic lung disease of infancy. Curr Opin Pediatr. 2019;31:357–66.
Hysinger EB. Central airway issues in bronchopulmonary dysplasia. Pediatr Pulmonol. 2021;56:3518–26.
Article PubMed PubMed Central Google Scholar
Gunatilaka CC, McKenzie C, Hysinger EB, Xiao Q, Higano NS, Woods JC, et al. Tracheomalacia Reduces Aerosolized Drug Delivery to the Lung. J Aerosol Med Pulm Drug Deliv. 2024;37:19–29.
Terry PB, Traystman RJ. The Clinical Significance of Collateral Ventilation. Ann Am Thorac Soc. 2016;13:2251–7.
Article PubMed PubMed Central Google Scholar
Di Cicco M, Kantar A, Masini B, Nuzzi G, Ragazzo V, Peroni D. Structural and functional development in airways throughout childhood: Children are not small adults. Pediatr Pulmonol. 2021;56:240–51.
Davies H, Kitchman R, Gordon I, Helms P. Regional ventilation in infancy. Reversal of adult pattern. N. Engl J Med. 1985;313:1626–8.
Article PubMed CAS Google Scholar
Davies H, Helms P, Gordon I. Effect of posture on regional ventilation in children. Pediatr Pulmonol. 1992;12:227–32.
Article PubMed CAS Google Scholar
West JB, Luks AM. West’s Respiratory Physiology. 10th edn. Philadelphia, PA: Wolters Kluwer; 2016.
Rubin BK. Taxonomy of Mucoactive Medications. In: Rubin BK, van der Schans CP, editors. Therapy for Mucus-Clearance Disorders. Marcel Dekker: New York, NY, 2004, pp 129–45.
Rubin BK. The pharmacologic approach to airway clearance: mucoactive agents. Paediatr Respir Rev. 2006;7:S215–9.
Rubin BK. Mucolytics, expectorants, and mucokinetic medications. Respir Care. 2007;52:859–65.
Lieberman J. Dornase aerosol effect on sputum viscosity in cases of cystic fibrosis. JAMA. 1968;205:312–3.
Article PubMed CAS Google Scholar
O’Donnell AE, Barker AF, Ilowite JS, Fick RB. Treatment of idiopathic bronchiectasis with aerosolized recombinant human DNase I. rhDNase Study Group. Chest. 1998;113:1329–34.
Reiter PD, Townsend SF, Velasquez R. Dornase alfa in premature infants with severe respiratory distress and early bronchopulmonary dysplasia. J Perinatol. 2000;20:530–4.
Article PubMed CAS Google Scholar
El Hassan NO, Chess PR, Huysman MW, Merkus PJ, de Jongste JC. Rescue use of DNase in critical lung atelectasis and mucus retention in premature neonates. Pediatrics. 2001;108:468–70.
Article PubMed CAS Google Scholar
MacKinnon R, Wheeler KI, Sokol J. Endotracheal DNase for atelectasis in ventilated neonates. J Perinatol. 2011;31:799–801.
留言 (0)