Background: This study examined the acute and sub-acute toxic effects ofTerminalia chebulaandAchillea wilhelmsiiextracts on the murine model.

Methods: In both phases, mice were assigned to intervention and control groups. At the end of study, the liver, kidney, and heart tissues were collected for histopathological studies.

Results: In the acute phase of the study, the safe dose was ≤5000 mg/kg for both extracts. In sub-acute phase, LD50 (95% CI) ofAchillea wilhelmsiiextract was determined ≥5000 mg/kg and that ofTerminalia chebulaextract 2754.436 (2438-3114) mg/kg. The highest dose ofT. chebulaextract induced few histopathological changes.

Conclusion: It will be useful to gain information on the minimum lethal doses ofT. chebulaandA. wilhelmsiito adopt safe doses of the two plants.

Jafari, Mahnaz; Naeini, Kourosh Manochehri; Lorigooini, Zahra; and Namjoo, Rasool () "Oral acute and sub-acute toxic effects of hydroalcoholicTerminalia chebulaRetz andAchillea wilhelmsiiextracts in BALB/c mice," BioMedicine: Vol. 9 : Iss. 4 , Article 4.
DOI: 10.37796/2211-8039.1616