High blood glucose level can cause diabetes, which in turn lead to various diseases, such as cardiovascular and cerebrovascular diseases, so monitoring of blood glucose levels is urgent. Here, we report persistent luminescent nanoparticles (PLNP), Zn1.1Cu0.001In0.0009Ga1.8Ge0.1O4 (ZCIGG), to avoid the interference of background fluorescence in conventional optical sensing and surface-loaded with MnO2 nanozymes for bimodal glucose detection. The two detection modes are validated with each other and are suitable for a wide range of occasions. To this end, ZCIGG was prepared with the afterglow emission at 500 nm and then integrated MnO2 nanosheet through dissolved oxygen strategy. MnO2 shows broad absorption and quenches the phosphorescence of ZCIGG. MnO2 acts as a peroxidase-like enzyme to catalyze H2O2-tetramethylbenzidine (TMB) reaction for the colorimetric detection of glucose, in the presence of glucose oxidase (GOx); MnO2 also acts as oxidase to catalyze the oxidation of H2O2 to produce Mn2+ and recover the afterglow emission for the phosphorescence detection of glucose. Density functional theory and microscopic kinetic modelling provide a theoretical analysis of the catalytic mechanism of MnO2 nanozymes for the dual-modality detection. We also developed mobile phone-based intelligent analysis platform using Python algorithm for convenient on-site colorimetric and phosphorescent dual-detection of glucose.

You have access to this article

Please wait while we load your content... Something went wrong. Try again?