Vingren JL, Kraemer WJ, Ratamess NA et al (2010) Testosterone physiology in resistance exercise and training: the up-stream regulatory elements. Sports Med 40:1037–1053

Article  PubMed  Google Scholar 

Miller WL (1988) Molecular biology of steroid hormone synthesis. Endocr Rev 9:295–318

Article  CAS  PubMed  Google Scholar 

Halpern JA, Brannigan RE (2019) Testosterone deficiency. JAMA 322:1116

Article  PubMed  Google Scholar 

Andropause BJ (2001) Testosterone replacement therapy for aging men. Can Fam Phys 47:91–97

Google Scholar 

Hazzard WR (1989) Why do women live longer than men? Biologic differences that influence longevity. Postgrad Med 85(271–278):281–273

Google Scholar 

Li SA, Watanabe M, Yamada H et al (2004) Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice. Cell Struct Funct 29:91–99

Article  CAS  PubMed  Google Scholar 

Chen CD, Sloane JA, Li H et al (2013) The anti-aging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS. J Neurosci 33:1927–1939

Article  CAS  PubMed  PubMed Central  Google Scholar 

Faul C, Amaral AP, Oskouei B et al (2011) FGF23 induces left ventricular hypertrophy. J Clin Invest 121:4393–4408

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi M, Flores B, Gillings N et al (2016) αKlotho mitigates progression of AKI to CKD through activation of autophagy. J Am Soc Nephrol 27:2331–2345

Article  CAS  PubMed  Google Scholar 

Pastor J, Moe OW (2019) Treating systemic klotho deficiency. Am J Nephrol 49:410–412

Article  PubMed  Google Scholar 

Abraham CR, Li A (2022) Aging-suppressor Klotho: prospects in diagnostics and therapeutics. Ageing Res Rev 82:101766

Article  CAS  PubMed  Google Scholar 

Dote-Montero M, De-la OA, Castillo MJ et al (2020) Predictors of sexual desire and sexual function in sedentary middle-aged adults: the role of lean Mass index and S-Klotho plasma levels. The FIT-AGEING Study. J Sex Med 17:665–677

Article  CAS  PubMed  Google Scholar 

Cao Q, Zhang J, Hao X et al (2024) The association between testosterone and serum soluble klotho in the females: evidence from the NHANES database. Front Endocrinol (Lausanne) 15:1335611

Article  PubMed  Google Scholar 

Xu Y, Sun Z (2015) Molecular basis of Klotho: from gene to function in aging. Endocr Rev 36:174–193

Article  CAS  PubMed  PubMed Central  Google Scholar 

Borrud L, Chiappa MM, Burt VL et al (2014) National Health and Nutrition Examination Survey: national youth fitness survey plan, operations, and analysis, 2012. Vital Health Stat 2:1–24

Google Scholar 

Curtin LR, Mohadjer LK, Dohrmann SM et al (2012) The National Health and Nutrition Examination Survey: sample design, 1999–2006. Vital Health Stat 2:1–39

Google Scholar 

Yamazaki Y, Imura A, Urakawa I et al (2010) Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects. Biochem Biophys Res Commun 398:513–518

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tao L, Miao L, Guo YJ et al (2024) Associations of body roundness index with cardiovascular and all-cause mortality: NHANES 2001–2018. J Hum Hypertens 38:120–127

Article  PubMed  Google Scholar 

Levey AS, Stevens LA, Schmid CH et al (2009) A new equation to estimate glomerular filtration rate. Ann Intern Med 150:604–612

Article  PubMed  PubMed Central  Google Scholar 

Imai K, Keele L, Tingley D (2010) A general approach to causal mediation analysis. Psychol Methods 15:309–334

Article  PubMed  Google Scholar 

Dote-Montero M, Amaro-Gahete FJ, De-la OA et al (2019) Study of the association of DHEAS, testosterone and cortisol with S-Klotho plasma levels in healthy sedentary middle-aged adults. Exp Gerontol 121:55–61

Article  CAS  PubMed  Google Scholar 

Glover F, Sullivan E, Mulloy E et al (2024) The relationship between klotho, testosterone, and sexual health parameters among US adult men. J Endocrinol Invest 47:523–533

Article  CAS  PubMed  Google Scholar 

Hsu SC, Huang SM, Lin SH et al (2014) Testosterone increases renal anti-aging klotho gene expression via the androgen receptor-mediated pathway. Biochem J 464:221–229

Article  CAS  PubMed  Google Scholar 

Zeng X, Zhong Q, Li M et al (2023) Androgen increases klotho expression via the androgen receptor-mediated pathway to induce GCs apoptosis. J Ovarian Res 16:10

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pi M, Quarles LD (2013) Novel bone endocrine networks integrating mineral and energy metabolism. Curr Osteoporos Rep 11:391–399

Article  PubMed  PubMed Central  Google Scholar 

Lim K, Groen A, Molostvov G et al (2015) α-Klotho expression in human tissues. J Clin Endocrinol Metab 100:E1308-1318

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao W, Zheng RD, Xu SH et al (2017) Association between sex hormone and blood uric acid in male patients with type 2 diabetes. Int J Endocrinol 2017:4375253

Article  PubMed  PubMed Central  Google Scholar 

Wan H, Zhang K, Wang Y et al (2020) The Associations between gonadal hormones and serum uric acid levels in men and postmenopausal women with diabetes. Front Endocrinol (Lausanne) 11:55

Article  PubMed  Google Scholar 

Krysiak R, Gilowski W, Okopień B (2016) The effect of testosterone on cardiometabolic risk factors in atorvastatin-treated men with late-onset hypogonadism. Pharmacol Rep 68:196–200

Article  CAS  PubMed  Google Scholar 

Han Y, Zhang Y, Cao Y et al (2021) Exploration of the association between serum uric acid and testosterone in adult males: NHANES 2011–2016. Transl Androl Urol 10:272–282

Article  CAS  PubMed  PubMed Central  Google Scholar 

Allsop J, Watts RW (1986) Purine phosphoribosyltransferase (EC 2.4.2.7 and 2.4.2.8) and purine de novo synthesis activity in rat testicular tissue at different stages of development, and their correlation with the circulating levels of gonadotrophins and testosterone, and with structural changes. Differentiation 32:144–147

Article  CAS  PubMed  Google Scholar 

Travison TG, Vesper HW, Orwoll E et al (2017) Harmonized reference ranges for circulating testosterone levels in men of four cohort studies in the United States and Europe. J Clin Endocrinol Metab 102:1161–1173

Article  PubMed  PubMed Central  Google Scholar 

Gherghina ME, Peride I, Tiglis M et al (2022) Uric acid and oxidative stress-relationship with cardiovascular, metabolic, and renal impairment. Int J Mol Sci 23:3188

Article  CAS  PubMed  PubMed Central  Google Scholar 

Glantzounis GK, Tsimoyiannis EC, Kappas AM et al (2005) Uric acid and oxidative stress. Curr Pharm Des 11:4145–4151

Article  CAS