As the main treatment modality of central neural system germinomas is radiotherapy and/or chemotherapy, the exact initial diagnosis of the disease is crucial. Depending on the different national protocols, histologic verification can be obligatory in some instances. This is a serious challenge, taking into account the usual location and nonspecific macroscopic appearance of these lesions. Here, we propose a safe and effective method of intraoperative tumor enhancement that can increase the confidence of the surgeon during the intervention.

This study protocol was reviewed and approved by the Ethical Committee of University Hospital St. Ivan Rilski.

All the authors had substantial contributions to the conception or design of the work; the acquisition, analysis, or interpretation of data for the work; participated in drafting the work or reviewing it critically for important intellectual content; approved the final version of the manuscript; and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

The authors confirm their contribution to the final version of the article as follows: study conception and design: E.N.; data collection: E.N. and P.K.; interpretation of results: E.N., D.M., and K.M.; draft manuscript preparation: E.N. and V.P. All the authors reviewed the results and approved the final version of the manuscript.

Informed written consent was obtained from the participant in the study.

Received: 18 February 2024

Accepted: 14 August 2024

Accepted Manuscript online:
16 August 2024

Article published online:
16 October 2024

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