Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Tip for patients: Resistant depression is difficult to treat, but in patients 60 years and older, adding on aripiprazole to current medication may give the most balanced benefit for well-being, remitting depression, and lower fall risk compared with switching to bupropion.

Source Article: Lenze EJ, Mulsant BH, Roose SP, et al. Antidepressant Augmentation versus Switch in Treatment-Resistant Geriatric Depression. N Engl J Med. 2023 Mar 23;388(12):1067–1079. doi: 10.1056/NEJMoa2204462. Epub 2023 Mar 3. PMID: 36867173; PMCID: PMC10568698.