GBD 2019 Blindness and Vision Impairment Collaborators, on belhalf of Vision Loss Expert Group of the Global Burden of Disease Study. Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to vision 2020: the right to sight: an analysis for the global burden of disease study. Lancet Glob Health. 2021;9:e144–60.

Brown DM, Michels M, Kaiser PK, Heier JS, Sy JP, Ianchulev T, et al. Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: Two-year results of the anchor study. Ophthalmology. 2009;116:57–65e5.

Article  PubMed  Google Scholar 

Comparison of Age-related Macular Degeneration Treatments Trials Research Group, Martin DF, Maguire MG, Ying GS, Grunwald JE, Fine SL, et al. Ranibizumab and bevacizumab for neovascular age-related macular degeneration. N Engl J Med. 2011;364:1897–908.

Article  Google Scholar 

Schmidt-Erfurth U, Kaiser PK, Korobelnik JF, Brown DM, Chong V, Nguyen QD, et al. Intravitreal aflibercept injection for neovascular age-related macular degeneration: Ninety-six-week results of the view studies. Ophthalmology. 2014;121:193–201.

Article  PubMed  Google Scholar 

Campochiaro PA, Aiello LP, Rosenfeld PJ. Anti-vascular endothelial growth factor agents in the treatment of retinal disease: From bench to bedside. Ophthalmology. 2016;123:S78–88.

Article  PubMed  Google Scholar 

Comparison of Age-related Macular Degeneration Treatments Trials Research Group, Martin DF, Maguire MG, Fine SL, Ying GS, Jaffe GJ, et al. Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: Two-year results. Ophthalmology. 2012;119:1388–98.

Article  Google Scholar 

Heier JS, Lad EM, Holz FG, Rosenfeld PJ, Guymer RH, Boyer D, et al. Pegcetacoplan for the treatment of geographic atrophy secondary to age-related macular degeneration (OAKS and DERBY): Two multicentre, randomised, double-masked, sham-controlled, phase 3 trials. Lancet. 2023;402:1434–48.

Article  CAS  PubMed  Google Scholar 

Khanani AM, Patel SS, Staurenghi G, Tadayoni R, Danzig CJ, Eichenbaum DA, et al. Efficacy and safety of avacincaptad pegol in patients with geographic atrophy (GATHER2): 12-month results from a randomised, double-masked, phase 3 trial. Lancet. 2023;402:1449–58.

Article  CAS  PubMed  Google Scholar 

Cruz-Pimentel M, Wu L. Complement inhibitors for advanced dry age-related macular degeneration (geographic atrophy): Some light at the end of the tunnel? J Clin Med. 2023;12:5131.

Spaide RF, Vavvas DG. Complement inhibition for geographic atrophy: Review of salient functional outcomes and perspective. Retina. 2023;43:1064–9.

Article  PubMed  Google Scholar 

Bird AC, Bressler NM, Bressler SB, Chisholm IH, Coscas G, Davis MD, et al. An international classification and grading system for age-related maculopathy and age-related macular degeneration. Int Arm Epidemiological Study Group Surv Ophthalmol. 1995;39:367–74.

CAS  Google Scholar 

Schmitz-Valckenberg S, Sahel JA, Danis R, Fleckenstein M, Jaffe GJ, Wolf S, et al. Natural history of geographic atrophy progression secondary to age-related macular degeneration (geographic atrophy progression study). Ophthalmology. 2016;123:361–8.

Article  PubMed  Google Scholar 

Liao DS, Grossi FV, El Mehdi D, Gerber MR, Brown DM, Heier JS, et al. Complement c3 inhibitor pegcetacoplan for geographic atrophy secondary to age-related macular degeneration: A randomized phase 2 trial. Ophthalmology. 2020;127:186–95.

Article  PubMed  Google Scholar 

Schmitz-Valckenberg S, Fleckenstein M, Gobel AP, Hohman TC, Holz FG. Optical coherence tomography and autofluorescence findings in areas with geographic atrophy due to age-related macular degeneration. Invest Ophthalmol Vis Sci. 2011;52:1–6.

Article  PubMed  Google Scholar 

Sadda SR, Guymer R, Holz FG, Schmitz-Valckenberg S, Curcio CA, Bird AC, et al. Consensus definition for atrophy associated with age-related macular degeneration on OCT: Classification of atrophy report 3. Ophthalmology. 2018;125:537–48.

Article  PubMed  Google Scholar 

Guymer RH, Rosenfeld PJ, Curcio CA, Holz FG, Staurenghi G, Freund KB, et al. Incomplete retinal pigment epithelial and outer retinal atrophy in age-related macular degeneration: Classification of atrophy meeting report 4. Ophthalmology. 2020;127:394–409.

Article  PubMed  Google Scholar 

Wu Z, Pfau M, Blodi BA, Holz FG, Jaffe GJ, Liakopoulos S, et al. OCT signs of early atrophy in age-related macular degeneration: Interreader agreement: Classification of atrophy meetings report 6. Ophthalmol Retin. 2022;6:4–14.

Article  Google Scholar 

Schaal KB, Gregori G, Rosenfeld PJ. En face optical coherence tomography imaging for the detection of nascent geographic atrophy. Am J Ophthalmol. 2017;174:145–54.

Article  PubMed  Google Scholar 

Liu J, Laiginhas R, Corvi F, Ferris FL 3rd, Lim TH, et al. Diagnosing persistent hypertransmission defects on en face OCT imaging of age-related macular degeneration. Ophthalmol Retin. 2022;6:387–97.

Article  Google Scholar 

Laiginhas R, Shi Y, Shen M, Jiang X, Feuer W, Gregori G, et al. Persistent hypertransmission defects detected on en face swept source optical computed tomography images predict the formation of geographic atrophy in age-related macular degeneration. Am J Ophthalmol. 2022;237:58–70.

Article  PubMed  Google Scholar 

Nanegrungsunk O, Corradetti G, Phinyo P, Choovuthayakorn J, Sadda SR. Prevalence and persistence of hypertransmission defects of various sizes in eyes with intermediate age-related macular degeneration. Retina. 2024;44:20–7.

CAS  PubMed  Google Scholar 

Shi Y, Yang J, Feuer W, Gregori G, Rosenfeld PJ. Persistent hypertransmission defects on en face OCT imaging as a stand-alone precursor for the future formation of geographic atrophy. Ophthalmol Retin. 2021;5:1214–25.

Article  Google Scholar 

Ferris FL 3rd, Wilkinson CP, Bird A, Chakravarthy U, Chew E, et al. Clinical classification of age-related macular degeneration. Ophthalmology. 2013;120:844–51.

Article  PubMed  Google Scholar 

Wakatsuki Y, Hirabayashi K, Yu HJ, Marion KM, Corradetti G, Wykoff CC, et al. Optical coherence tomography biomarkers for conversion to exudative neovascular age-related macular degeneration. Am J Ophthalmol. 2023;247:137–44.

Article  CAS  PubMed  Google Scholar 

Shi Y, Motulsky EH, Goldhardt R, Zohar Y, Thulliez M, Feuer W, et al. Predictive value of the OCT double-layer sign for identifying subclinical neovascularization in age-related macular degeneration. Ophthalmol Retin. 2019;3:211–19.

Article  Google Scholar 

Hirabayashi K, Yu HJ, Wakatsuki Y, Marion KM, Wykoff CC, Sadda SR. OCT risk factors for development of atrophy in eyes with intermediate age-related macular degeneration. Ophthalmol Retin. 2023;7:253–60.

Article  Google Scholar 

Spaide RF, Jaffe GJ, Sarraf D, Reund KB, Sadda SR, et al. Consensus nomenclature for reporting neovascular age-related macular degeneration data: Consensus on neovascular age-related macular degeneration nomenclature study group. Ophthalmology. 2020;127:616–36.

Article  PubMed  Google Scholar 

Corradetti G, Corvi F, Nittala MG, Nassisi M, Alagorie AR, Scharf J, et al. Natural history of incomplete retinal pigment epithelial and outer retinal atrophy in age-related macular degeneration. Can J Ophthalmol. 2021;56:325–34.

Article  PubMed  Google Scholar 

Corvi F, Corradetti G, Laiginhas R, Liu J, Gregori G, Rosenfeld PJ, et al. Comparison between b-scan and en face images for incomplete and complete retinal pigment epithelium and outer retinal atrophy. Ophthalmol Retin. 2023;7:999–1009.

Article  Google Scholar 

Jaffe GJ, Chakravarthy U, Freund KB, Guymer RH, Holz FG, Liakopoulos S, et al. Imaging features associated with progression to geographic atrophy in age-related macular degeneration: Classification of atrophy meeting report 5. Ophthalmol Retin. 2021;5:855–67.

Article  Google Scholar 

Wu Z, Luu CD, Hodgson LAB, Caruso E, Tindill N, Aung KZ, et al. Prospective longitudinal evaluation of nascent geographic atrophy in age-related macular degeneration. Ophthalmol Retin. 2020;4:568–75.

Article  Google Scholar 

Corvi F, Corradetti G, Nittala MG, Velaga SB, Haines JL, Pericak-Vance MA, et al. Comparison of spectralis and cirrus optical coherence tomography for the detection of incomplete and complete retinal pigment epithelium and outer retinal atrophy. Retina. 2021;41:1851–7.

Article  CAS  PubMed  Google Scholar 

Kalra G, Cetin H, Whitney J, Yordi S, Cakir Y, McConville C, et al. Machine learning-based automated detection and quantification of geographic atrophy and hypertransmission defects using spectral domain optical coherence tomography. J Pers Med. 2022;13:37.

Article  PubMed  PubMed Central  Google Scholar 

Liu J, Shen M, Laiginhas R, Herrera G, Li J, Shi Y, et al. Onset and progression of persistent choroidal hypertransmission defects in intermediate age-related macular degeneration: A novel clinical trial endpoint. Am J Ophthalmol. 2023;254:11–22.

Article  PubMed  Google Scholar