Significance of FSHR and LHCGR gene polymorphisms on clinical outcomes in gonadotropin-releasing hormone antagonist protocol with freeze-all strategy: A case-control study

[1] Borumandnia N, Alavi Majd H, Khadembashi N, Alaii H. Worldwide trend analysis of primary and secondary infertility rates over past decades: A cross-sectional study. Int J Reprod BioMed 2022; 20: 37–46.

[2] Cox CM, Thoma ME, Tchangalova N, Mburu G, Bornstein MJ, Johnson CL, et al. Infertility prevalence and the methods of estimation from 1990 to 2021: A systematic review and meta-analysis. Hum Reprod Open 2022; 2022: hoac051.

[3] Racca A, Drakopoulos P, Neves AR, Polyzos NP. Current therapeutic options for controlled ovarian stimulation in assisted reproductive technology. Drugs 2020; 80: 973–994.

[4] Fatemi H, Bilger W, Denis D, Griesinger G, La Marca A, Longobardi S, et al. Dose adjustment of folliclestimulating hormone (FSH) during ovarian stimulation as part of medically-assisted reproduction in clinical studies: A systematic review covering 10 years (2007– 2017). Reprod Biol Endocrinol 2021; 11: 68.

[5] Alviggi C, Longobardi S, Papaleo E, Santi D, Alfano S, Vanni VS, et al. Genetic variants of gonadotropins and their receptors could influence controlled ovarian stimulation: IVF data from a prospective multicenter study. Genes 2023; 14: 1269.

[6] Conforti A, Tuettelmann F, Alviggi C, Behre HM, Fischer R, Hu L, et al. Effect of genetic variants of gonadotropins and their receptors on ovarian stimulation outcomes: A delphi consensus. Front Endocrinol 2022; 12: 797365.

[7] Ga R, Cheemakurthi R, Kalagara M, Prathigudupu K, Balabomma KL, Mahapatro P, et al. Effect of LHCGR gene polymorphism (rs2293275) on LH supplementation protocol outcomes in second IVF cycles: A retrospective study. Front Endocrinol 2012; 12: 628169.

[8] Polyzos NP, Neves AR, Drakopoulos P, Spits C, Alvaro Mercadal B, Garcia S, et al. The effect of polymorphisms in FSHR and FSHB genes on ovarian response: A prospective multicenter multinational study in Europe and Asia. Hum Reprod 2021; 36: 1711–1721.

[9] Meireles AJ, Bilibio JP, Lorenzzoni PL, De Conto E, do Nascimento FC, da Cunha-Filho JS. Association of FSHR, LH, LHR, BMP15, GDF9, AMH, and AMHR polymorphisms with poor ovarian response in patients undergoing in vitro fertilization. JBRA Assist Reprod 2021; 25: 439.

[10] Sindiani AM, Batiha O, Khadrawi S, Alsoukhni G, Alkofahi A, Alahmad NA, et al. Association of singlenucleotide polymorphisms in the ESR2 and FSHR genes with poor ovarian response in infertile Jordanian women. Clin Exp Reprod Med 2021; 48: 69.

[11] Tzoupis H, Nteli A, Androutsou ME, Tselios T. Gonadotropin-releasing hormone and GnRH receptor: Structure, function and drug development. Curr Med Chem 2020; 27: 6136–6158.

[12] Clément F, Yvinec R, Gallay N, Gagniac L, Guillou F, Crépieux P. The follicle-stimulating hormone signaling network in gonadal cells. In: Ulloa-Aguirre A, Conn PM. Cellular endocrinology in health and disease. USA: Academic Press; 2014.

[13] Oduwole OO, Huhtaniemi IT, Misrahi M. The roles of luteinizing hormone, follicle-stimulating hormone and testosterone in spermatogenesis and folliculogenesis revisited. Int J Mol Sci 2021; 22: 12735.

[14] Lindgren I, Nenonen H, Henic E, Bungum L, Prahl A, Bungum M, et al. Gonadotropin receptor variants are linked to cumulative live birth rate after in vitro fertilization. J Assist Reprod Genet 2019; 36: 29–38.

[15] Paschalidou C, Anagnostou E, Mavrogianni D, Raouasnte R, Klimis N, Drakakis P, et al. The effects of follicle-stimulating hormone receptor (FSHR)-29 and Ser680Asn polymorphisms in IVF/ICSI. Horm Mol Biol Clin Investig 2020; 41: 20190058.

[16] Althumairy D, Zhang X, Baez N, Barisas G, Roess DA, Bousfield GR, et al. Glycoprotein G-protein coupled receptors in disease: Luteinizing hormone receptors and follicle stimulating hormone receptors. Diseases 2020; 8: 35.

[17] Haldar S, Agrawal H, Saha S, Straughn AR, Roy P, Kakar SS. Overview of follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells. Int J Biol Sci 2022; 18: 675–692.

[18] Themmen AP, Huhtaniemi IT. Mutations of gonadotropins and gonadotropin receptors: Elucidating the physiology and pathophysiology of pituitary-gonadal function. Endocr Rev 2000; 21: 551–583.

[19] Casarini L, Lazzaretti C, Paradiso E, Limoncella S, Riccetti L, Sperduti S, et al. Membrane estrogen receptor (GPER) and follicle-stimulating hormone receptor (FSHR) heteromeric complexes promote human ovarian follicle survival. Iscience 2020; 23: 101812.

[20] Tang H, Yan Y, Wang T, Zhang T, Shi W, Fan R, et al. Effect of follicle-stimulating hormone receptor Asn680Ser polymorphism on the outcomes of controlled ovarian hyperstimulation: An updated meta-analysis of 16 cohort studies. J Assist Reprod Genet 2015; 32: 1801–1810.

[21] König TE, van der Lee J, Schats R, Lambalk CB. The relationship between FSH receptor polymorphism status and IVF cycle outcome: A retrospective observational study. Reprod BioMed Online 2019; 39: 231–240.

[22] Guo C, Yu H, Feng G, Lv Q, Liu X, Liu X. Associations of FSHR and LHCGR gene variants with ovarian reserve and clinical pregnancy rates. Reprod BioMed Online 2021; 43: 561–569.

[23] Bianco B, Loureiro FA, Trevisan CM, Peluso C, Christofolini DM, Montagna E, et al. Effects of FSHR and FSHB variants on hormonal profile and reproductive outcomes of infertile women with endometriosis. Front Endocrinol 2021; 12: 760616.

[24] Jin H, Yang H, Zheng J, Zhou J, Yu R. Posttrigger luteinizing hormone concentration to positively predict oocyte yield in the antagonist protocol and its association with genetic variants of LHCGR. J Ovarian Res 2023; 16: 189.

[25] Peluso C, Oliveira RD, Laporta GZ, Christofolini DM, Fonseca FL, Laganà AS, et al. Are ovarian reserve tests reliable in predicting ovarian response? Results from a prospective, cross-sectional, single-center analysis. Gynecol Endocrinol 2021; 37: 358–366.

[26] Paffoni A, Cesana S, Corti L, Ballabio E, Salemi C, Kunderfranco A, et al. Pregnancy rate in IVF patients with unexpected poor response to ovarian stimulation. Gynecol Endocrinol 2022; 38: 736–741.

留言 (0)

沒有登入
gif