Stubbins RJ, Stamenkovic M, Roy C, Rodrigo J, Chung S, Kuchenbauer FC et al (2022) Incidence and socioeconomic factors in older adults with acute myeloid leukaemia: real-world outcomes from a population-based cohort. Eur J Haematol 108:437–445

Article  PubMed  Google Scholar 

Appelbaum FR, Gundacker H, Head DR, Slovak ML, Willman CL, Godwin JE et al (2006) Age and acute myeloid leukemia. Blood 107(9):3481–3485

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liersch R, Müller-Tidow C, Berdel WE, Krug U (2014) Prognostic factors for acute myeloid leukaemia in adults–biological significance and clinical use. Br J Haematol 165:17–38

Article  PubMed  Google Scholar 

Döhner H, Estey E, Grimwade D, Amadori S, Appelbaum FR, Büchner T et al (2017) Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. Blood 129(4):424–447

Article  PubMed  PubMed Central  Google Scholar 

Cancer stat facts: Leukemia-Acute Myeloid Leukemia (AML) [(accessed on 18 May 2022)]; Available online: https://seer.cancer.gov/statfacts/html/amyl.html

Nagel G, Weber D, Fromm E, Erhardt S, Lübbert M, Fiedler W et al (2017) Epidemiological, genetic, and clinical characterization by age of newly diagnosed acute myeloid leukemia based on an academic population-based registry study (AMLSG BiO). Ann Hematol 96(12):1993–2003

Article  PubMed  PubMed Central  Google Scholar 

Juliusson G, Antunovic P, Derolf A, Lehmann S, Möllgård L, Stockelberg D et al (2009) Age and acute myeloid leukemia: real world data on decision to treat and outcomes from the Swedish Acute Leukemia Registry. Blood 113(18):4179–4187

Article  CAS  PubMed  Google Scholar 

Rees JK, Gray RG, Swirsky D, Hayhoe FG (1986) Principal results of the Medical Research Council’s 8th acute myeloid leukaemia trial. Lancet 2(8518):1236–1241

Article  CAS  PubMed  Google Scholar 

Portugal RD, Garnica M, Nucci M (2009) Index to predict invasive mold infection in high-risk neutropenic patients based on the area over the neutrophil curve. J Clin Oncol 27(23):3849–3854

Article  PubMed  Google Scholar 

Matsushima S, Kobayashi R, Sano H, Hori D, Yanagi M, Kodama K et al (2021) Comparison of myelosuppression using the D-index between children and adolescents/young adults with acute lymphoblastic leukemia during induction chemotherapy. Pediatr Blood Cancer 68(2):e28763

Article  CAS  PubMed  Google Scholar 

Donnelly JP, Chen SC, Kauffman CA, Steinbach WJ, Baddley JW, Verweij PE et al (2020) Revision and update of the consensus definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium. Clin Infect Dis 71(6):1367–1376

Article  PubMed  Google Scholar 

Kanda Y (2013) Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant 48(3):452–458

Article  CAS  PubMed  Google Scholar 

Kanda Y, Yamamoto R, Chizuka A, Hamaki T, Suguro M, Arai C et al (2000) Prophylactic action of oral fluconazole against fungal infection in neutropenic patients. A meta-analysis of 16 randomized, controlled trials. Cancer 89:1611–25

Article  CAS  PubMed  Google Scholar 

Tilly H, Castaigne S, Bordessoule D, Casassus P, Pris PYL, Tertian G et al (1990) Low-dose cytarabine versus intensive chemotherapy in the treatment of acute nonlympho-cytic leukemia in the elderly. J Clin Oncol 8:272–279

Article  CAS  PubMed  Google Scholar 

Kahn SB, Begg CB, Mazza JJ, Bennett JM, Bonner H, Glick JH (1984) Full dose versus attenuated dose daunorubicin, cytosine arabinoside, and 6-thioguanine in the treatment of acute nonlymphocytic leukemia in the elderly. J Clin Oncol. 2:865–70

Article  CAS  PubMed  Google Scholar 

Hamaker ME, Stauder R, van Munster BC (2014) Exclusion of older patients from ongoing clinical trials for hematological malignancies: an evaluation of the National Institutes of Health clinical trial registry. Oncologist 19:1069–1075

Article  PubMed  PubMed Central  Google Scholar 

Kimura K, Ohno R, Amaki I, Hattori K, Hirota Y, Hoshino A et al (1985) Treatment of acute myelogenous leukemia in adults with N4-behenoyl-1-beta-D-arabinofuranosylcytosine. Cancer 56(8):1913–1917

Article  CAS  PubMed  Google Scholar 

Ohno R, Kato Y, Nagura E, Murase T, Okumura M, Yamada H et al (1986) Behenoyl cytosine arabinoside, daunorubicin, 6-mercaptopurine, and prednisolone combination therapy for acute myelogenous leukemia in adults and prognostic factors related to remission duration and survival length. J Clin Oncol 4(12):1740–1747

Article  CAS  PubMed  Google Scholar 

Yoshida M, Suda K, Tsuboyama A, Sasaki R, Kitagawa S, Kano Y et al (1989) Behenoyl cytosine arabinoside, aclacinomycin A, 6-mercaptopurine, and prednisolone combination therapy for acute non-lymphocytic leukaemia in adults. Eur J Haematol 43(1):1–6

Article  CAS  PubMed  Google Scholar 

Ueda T, Nakamura T, Ando S, Kagawa D, Sasada M, Uchino H et al (1983) Pharmacokinetics of N4-behenoyl-1-beta-D-arabinofuranosylcytosine in patients with acute leukemia. Cancer Res. 43(7):3412–6

CAS  PubMed  Google Scholar