Yuan X, Liang F, Zhu J, Huang K, Dai L, Li X, et al. Maternal exposure to PM2.5 and the risk of congenital heart defects in 1.4 million births: a nationwide surveillance-based study. Circulation. 2023;147:565–74.

Article  PubMed  PubMed Central  Google Scholar 

Su Z, Zou Z, Hay SI, Liu Y, Li S, Chen H, et al. Global, regional, and national time trends in mortality for congenital heart disease, 1990-2019: an age-period-cohort analysis for the Global Burden of Disease 2019 study. EClin Med. 2022;43:101249.

Google Scholar 

Zhao QM, Liu F, Wu L, Ma XJ, Niu C, Huang GY. Prevalence of congenital heart disease at live birth in China. J Pediatr. 2019;204:53–8.

Article  PubMed  Google Scholar 

Snijder CA, Vlot IJ, Burdorf A, Obermann-Borst SA, Helbing WA, Wildhagen MF, et al. Congenital heart defects and parental occupational exposure to chemicals. Hum Reprod. 2012;27:1510–7.

Article  PubMed  CAS  Google Scholar 

Vicedo-Cabrera AM, Sera F, Liu C, Armstrong B, Milojevic A, Guo Y, et al. Short term association between ozone and mortality: global two stage time series study in 406 locations in 20 countries. BMJ. 2020;368:m108.

Article  PubMed  PubMed Central  Google Scholar 

Yang Y, Lin Q, Liang Y, Ruan Z, Acharya BK, Zhang S, et al. Maternal air pollution exposure associated with risk of congenital heart defect in pre-pregnancy overweighted women. Sci Total Environ. 2020;712:136470.

Article  PubMed  CAS  Google Scholar 

Lavigne E, Lima I, Hatzopoulou M, Van Ryswyk K, Decou ML, Luo W, et al. Spatial variations in ambient ultrafine particle concentrations and risk of congenital heart defects. Environ Int. 2019;130:104953.

Article  PubMed  CAS  Google Scholar 

Dadvand P, Rankin J, Rushton S, Pless-Mulloli T. Ambient air pollution and congenital heart disease: a register-based study. Environ Res. 2011;111:435–41.

Article  PubMed  CAS  Google Scholar 

Peyvandi S, De Santiago V, Chakkarapani E, Chau V, Campbell A, Poskitt KJ, et al. Association of prenatal diagnosis of critical congenital heart disease with postnatal brain development and the risk of brain injury. JAMA Pediatr. 2016;170:e154450.

Article  PubMed  PubMed Central  Google Scholar 

Donofrio MT, Moon-Grady AJ, Hornberger LK, Copel JA, Sklansky MS, Abuhamad A, et al. Diagnosis and treatment of fetal cardiac disease: a scientific statement from the American Heart Association. Circulation. 2014;129:2183–242.

Article  PubMed  Google Scholar 

Xue T, Zheng Y, Geng G, Xiao Q, Meng X, Wang M, et al. Estimating spatiotemporal variation in ambient ozone exposure during 2013-7 using a data-fusion model. Environ Sci Technol. 2020;54:14877–88.

Article  PubMed  CAS  Google Scholar 

Dadvand P, Rankin J, Rushton S, Pless-Mulloli T. Association between maternal exposure to ambient air pollution and congenital heart disease: a register-based spatiotemporal analysis. Am J Epidemiol. 2011;173:171–82.

Article  PubMed  Google Scholar 

International Society of Ultrasound in Obstetrics and Gynecology, Carvalho JS, Allan LD, Chaoui R, Copel JA, DeVore GR, et al. ISUOG Practice Guidelines (updated): sonographic screening examination of the fetal heart. Ultrasound Obstet Gynecol. 2013;41:348–59.

Article  PubMed  CAS  Google Scholar 

Gao S, Han J, Yu S, Guo Y, Ruan Y, Fu Y, et al. Comparison of fetal echocardiogram with fetal cardiac autopsy findings in fetuses with congenital heart disease. J Matern Fetal Neonatal Med. 2021;34:3844–50.

Article  PubMed  Google Scholar 

Xin Y, Yang Y, Chen X, Yue X, Liu Y, Yin C. Evaluation of IMERG and ERA5 precipitation products over the Mongolian Plateau. Sci Rep. 2022;12:21776.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Guo J, Ruan Y, Wang Y, Wang H, Ma S, Wan X, et al. Maternal exposure to extreme cold events and risk of congenital heart defects: a large multicenter study in China. Environ Sci Technol. 2024;58:3737–46.

Article  PubMed  CAS  Google Scholar 

R Core Team, 2023. R: a language and environment for statistical computing. R Foundation for Statistical Computing. https://www.r-project.org/.

Schultz WM, Kelli HM, Lisko JC, Varghese T, Shen J, Sandesara P, et al. Socioeconomic status and cardiovascular outcomes: challenges and interventions. Circulation. 2018;137:2166–78.

Article  PubMed  PubMed Central  Google Scholar 

Barigye O, Pasquini L, Galea P, Chambers H, Chappell L, Fisk NM. High risk of unexpected late fetal death in monochorionic twins despite intensive ultrasound surveillance: a cohort study. PLoS Med. 2005;2:e172.

Article  PubMed  PubMed Central  Google Scholar 

Huang CC, Chen BY, Pan SC, Ho YL, Guo YL. Prenatal exposure to PM2.5 and congenital heart diseases in Taiwan. Sci Tot. Environ. 2019;655:880–6.

Article  CAS  Google Scholar 

Zhang H, Zhang X, Zhao X, Cheng G, Chang H, Ye X, et al. Maternal exposure to air pollution and congenital heart diseases in Henan China: a register-based case-control study. Ecotoxicol Environ Saf. 2022;229:113070.

Article  PubMed  CAS  Google Scholar 

Jiang W, Liu Z, Ni B, Xie W, Zhou H, Li X. Independent and interactive effects of air pollutants and ambient heat exposure on congenital heart defects. Reprod Toxicol. 2021;104:106–13.

Article  PubMed  CAS  Google Scholar 

Zhang B, Zhao J, Yang R, Qian Z, Liang S, Bassig BA, et al. Ozone and other air pollutants and the risk of congenital heart defects. Sci Rep. 2016;6:34852.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Agay-Shay K, Friger M, Linn S, Peled A, Amitai Y, Peretz C. Air pollution and congenital heart defects. Environ Res. 2013;124:28–34.

Article  PubMed  CAS  Google Scholar 

Hwang BF, Lee YL, Jaakkola JJ. Air pollution and the risk of cardiac defects: a population-based case-control study. Medicine (Baltimore). 2015;94:e1883.

Article  PubMed  Google Scholar 

Vinikoor-Imler LC, Stewart TG, Luben TJ, Davis JA, Langlois PH. An exploratory analysis of the relationship between ambient ozone and particulate matter concentrations during early pregnancy and selected birth defects in Texas. Environ Pollut. 2015;202:1–6.

Article  PubMed  CAS  Google Scholar 

Ritz B, Yu F, Fruin S, Chapa G, Shaw GM, Harris JA. Ambient air pollution and risk of birth defects in Southern California. Am J Epidemiol. 2002;155:17–25.

Article  PubMed  Google Scholar 

Lu X, Zhang L, Wang X, Gao M, Li K, Zhang Y, et al. Rapid increases in warm-season surface ozone and resulting health impact in China since 2013. Environ Sci Technol Lett. 2020;74:240–7.

Article  Google Scholar 

Lepeule J, Litonjua AA, Gasparrini A, Koutrakis P, Sparrow D, Vokonas PS, et al. Lung function association with outdoor temperature and relative humidity and its interaction with air pollution in the elderly. Environ Res. 2018;165:110–7.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Xie X, Kong BH, Duan T. Gynecology and Obstetrics. 9th Edition, People’s Health Publishing House, Beijing, 2018.

Luderer U, Lim J, Ortiz L, Nguyen JD, Shin JH, Allen BD, et al. Exposure to environmentally relevant concentrations of ambient fine particulate matter (PM2.5) depletes the ovarian follicle reserve and causes sex-dependent cardiovascular changes in apolipoprotein E null mice. Part Fibre Toxicol. 2022;19:5.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Van Brusselen D, Kayembe-Kitenge T, Mbuyi-Musanzayi S, Lubala Kasole T, Kabamba Ngombe L, Musa Obadia P, et al. Metal mining and birth defects: a case-control study in Lubumbashi Democratic Republic of the Congo. Lancet Planet Health. 2020;4:e158–e167.

Article  PubMed  Google Scholar 

Gittenberger-de Groot AC, Bartelings MM, Deruiter MC, Poelmann RE. Basics of cardiac development for the understanding of congenital heart malformations. Pediatr Res. 2005;57:169–76.