Azziz R, Carmina E, Chen Z, Dunaif A, Laven JS, Legro RS, et al. Polycystic ovary syndrome. Nat Rev Dis Primers. 2016;2:16057. https://doi.org/10.1038/nrdp.2016.57.

Article  PubMed  Google Scholar 

Teede HJ, Tay CT, Laven JJE, Dokras A, Moran LJ, Piltonen TT, et al. Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Eur J Endocrinol. 2023;189(2):G43–64. https://doi.org/10.1093/ejendo/lvad096.

Article  PubMed  Google Scholar 

Kakoly NS, Khomami MB, Joham AE, Cooray SD, Misso ML, Norman RJ, et al. Ethnicity, obesity and the prevalence of impaired glucose tolerance and type 2 diabetes in PCOS: a systematic review and meta-regression. Hum Reprod Update. 2018;24(4):455–67. https://doi.org/10.1093/humupd/dmy007.

Article  CAS  PubMed  Google Scholar 

Zhao L, Zhu Z, Lou H, Zhu G, Huang W, Zhang S, et al. Polycystic ovary syndrome (PCOS) and the risk of coronary heart disease (CHD): a meta-analysis. Oncotarget. 2016;7(23):33715–21. https://doi.org/10.18632/oncotarget.9553.

Article  PubMed  PubMed Central  Google Scholar 

Lee I, Cooney LG, Saini S, Sammel MD, Allison KC, Dokras A. Increased odds of disordered eating in polycystic ovary syndrome: a systematic review and meta-analysis. Eat Weight Disord. 2019;24(5):787–97. https://doi.org/10.1007/s40519-018-0533-y.

Article  PubMed  Google Scholar 

Brutocao C, Zaiem F, Alsawas M, Morrow AS, Murad MH, Javed A. Psychiatric disorders in women with polycystic ovary syndrome: a systematic review and meta-analysis. Endocrine. 2018;62(2):318–25. https://doi.org/10.1007/s12020-018-1692-3.

Article  CAS  PubMed  Google Scholar 

Wright PJ, Dawson RM, Corbett CF. Social construction of biopsychosocial and medical experiences of women with polycystic ovary syndrome. J Adv Nurs. 2020;76(7):1728–36. https://doi.org/10.1111/jan.14371.

Article  PubMed  Google Scholar 

Dokras A, Stener-Victorin E, Yildiz BO, Li R, Ottey S, Shah D, et al. Androgen Excess-Polycystic Ovary Syndrome Society: position statement on depression, anxiety, quality of life, and eating disorders in polycystic ovary syndrome. Fertil Steril. 2018;109(5):888–99. https://doi.org/10.1016/j.fertnstert.2018.01.038.

Article  PubMed  Google Scholar 

Deeks A, Gibson-Helm M, Paul E, Teede H. Is having polycystic ovary syndrome a predictor of poor psychological function including anxiety and depression? Hum Reprod. 2011;26(6):1399–407. https://doi.org/10.1093/humrep/der071.

Article  CAS  PubMed  Google Scholar 

Handy AB, Greenfield SF, Yonkers KA, Payne LA. Psychiatric symptoms across the menstrual cycle in adult women: a comprehensive review. Harv Rev Psychiatry. 2022;30(2):100–17. https://doi.org/10.1097/HRP.0000000000000329.

Article  PubMed  PubMed Central  Google Scholar 

Nappi RE, Cucinella L, Bosoni D, Righi A, Battista F, Molinaro P, et al. Premenstrual syndrome and premenstrual dysphoric disorder as centrally based disorders. Endocrines. 2022;3(1):127–38.

Article  Google Scholar 

Chang RJ, Dumesic DA. Polycystic ovary syndrome and hyperandrogenic states. In: Strauss JF, Barbieri RL, editors. Yen and Jaffe’s reproductive endocrinology. Philadelphia: Elsevier; 2019.

Google Scholar 

Franks S, Hardy K. What causes anovulation in polycystic ovary syndrome? Curr Opin Endocrinol Diabetes Obes. 2020;12:59–65.

Google Scholar 

Walker K, Decherney AH, Saunders R. Menstrual dysfunction in PCOS. Clin Obstet Gynecol. 2021;64(1):119–25. https://doi.org/10.1097/GRF.0000000000000596.

Article  PubMed  Google Scholar 

Cen H, Zhang L, Liu F. Progesterone for premenstrual exacerbations of bipolar disorder in a 15-year-old girl with polycystic ovary syndrome. Bipolar Disord. 2024. https://doi.org/10.1111/bdi.13457.

Article  PubMed  Google Scholar 

McCartney CR, Marshall JC. Neuroendocrinology of reproduction. In: Strauss JF, Barbieri RL, editors. Yen and Jaffe’s reproductive endocrinology. Philadelphia: Elsevier; 2019.

Google Scholar 

Sarkisian KI, Ho L, Yang J, Mandelbaum R, Stanczyk FZ. Neuroendocrine, neurotransmitter, and gut microbiota imbalance contributing to potential psychiatric disorder prevalence in polycystic ovarian syndrome. Fertil Steril Rep. 2023;4(4):337–42. https://doi.org/10.1016/j.xfre.2023.08.009.

Article  Google Scholar 

Szeliga A, Rudnicka E, Maciejewska-Jeske M, Kucharski M, Kostrzak A, Hajbos M, et al. Neuroendocrine determinants of polycystic ovary syndrome. Int J Environ Res Public Health. 2022;19(5):3089. https://doi.org/10.3390/ijerph19053089.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aboeldalyl S, James C, Seyam E, Ibrahim EM, Shawki HE-D, Amer S. The role of chronic inflammation in polycystic ovarian syndrome—a systematic review and meta-analysis. Int J Mol Sci. 2021;22(5):2734.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hantsoo L, Jagodnik KM, Novick AM, Baweja R, di Scalea TL, Ozerdem A, et al. The role of the hypothalamic-pituitary-adrenal axis in depression across the female reproductive lifecycle: current knowledge and future directions. Front Endocrinol. 2023;14:1295261. https://doi.org/10.3389/fendo.2023.1295261.

Article  Google Scholar 

Gonzalez D, Maidana P, Ibar C, Jamardo J, Jacobsen D, Fritzler A, et al. Hair cortisol in polycystic ovary syndrome. Sci Rep. 2022;12(1):10309. https://doi.org/10.1038/s41598-022-14061-9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Standeven LR, Olson E, Leistikow N, Payne JL, Osborne LM, Hantsoo L. Polycystic ovary syndrome, affective symptoms, and neuroactive steroids: a focus on allopregnanolone. Curr Psychiatry Rep. 2021;23(6):36. https://doi.org/10.1007/s11920-021-01244-w.

Article  PubMed  PubMed Central  Google Scholar 

Amiri M, Bidhendi Yarandi R, Nahidi F, Tohidi M, Ramezani TF. The relationship between clinical and biochemical characteristics and quality of life in patients with polycystic ovary syndrome. Clin Endocrinol. 2019;90(1):129–37. https://doi.org/10.1111/cen.13858.

Article  CAS  Google Scholar 

Abdalla MA, Deshmukh H, Mohammed I, Atkin S, Reid M, Sathyapalan T. The effect of free androgen index on the quality of life of women with polycystic ovary syndrome: a cross-sectional study. Front Physiol. 2021;12:652559. https://doi.org/10.3389/fphys.2021.652559.

Article  PubMed  PubMed Central  Google Scholar 

Cameron IM, Crawford JR, Lawton K, Reid IC. Psychometric comparison of PHQ-9 and HADS for measuring depression severity in primary care. Br J Gen Pract. 2008;58(546):32–6. https://doi.org/10.3399/bjgp08X263794.

Article  PubMed  PubMed Central  Google Scholar 

Yoshida T, Saito K, Kawamura T, Ishikawa T, Kato T, Matsubara K, et al. Circulating steroids and mood disorders in patients with polycystic ovary syndrome. Steroids. 2021;165:108748. https://doi.org/10.1016/j.steroids.2020.108748.

Article  CAS  PubMed  Google Scholar 

Sahle BW, Reavley NJ, Li W, Morgan AJ, Yap MBH, Reupert A, et al. The association between adverse childhood experiences and common mental disorders and suicidality: an umbrella review of systematic reviews and meta-analyses. Eur Child Adolesc Psychiatry. 2022;31(10):1489–99. https://doi.org/10.1007/s00787-021-01745-2.

Article  PubMed  Google Scholar 

Yang Q, Thornorethardottir EB, Hauksdottir A, Aspelund T, Jakobsdottir J, Halldorsdottir T, et al. Association between adverse childhood experiences and premenstrual disorders: a cross-sectional analysis of 11,973 women. BMC Med. 2022;20(1):60. https://doi.org/10.1186/s12916-022-02275-7.

Article  PubMed  PubMed Central  Google Scholar 

Pilver CE, Levy BR, Libby DJ, Desai RA. Posttraumatic stress disorder and trauma characteristics are correlates of premenstrual dysphoric disorder. Arch Womens Ment Health. 2011;14(5):383–93. https://doi.org/10.1007/s00737-011-0232-4.

Article  PubMed  PubMed Central  Google Scholar 

Tay CT, Teede HJ, Loxton D, Kulkarni J, Joham AE. Psychiatric comorbidities and adverse childhood experiences in women with self-reported polycystic ovary syndrome: an Australian population-based study. Psychoneuroendocrinology. 2020;116:104678. https://doi.org/10.1016/j.psyneuen.2020.104678.

Article  PubMed  Google Scholar 

Pringle D, Suliman S, Seedat S, van den Heuvel LL. The impact of childhood maltreatment on women’s reproductive health, with a focus on symptoms of polycystic ovary syndrome. Child Abuse Negl. 2022;133:105831.