Authors Muhammad Hussain Siddiqui Department of Anatomy, Sindh Institute of Urology & Tranplantation (SIUT), Naheed Khan Department of Anatomy, Dow Medical College, Dow University of Health Sciences Naseem Ahmed Department of Pathology, Dow Medical College, Dow University of Health Sciences Tahir Hussain Department of Anatomy, United Medical & Dental College Naheed AKhtar 5Department of Anatomy, Karachi Institute of Medical Syeda Zain UMDC Karachi Keywords: Ginger, zingiber officinale, Tuberculosis, Isoniazid, Hepatotoxicity Abstract

Objective: Tuberculosis (TB) continues to exist as a fatal, rampant disease in most developing countries of the world, including Pakistan. Isoniazid (INH) is an effective drug of choice for the disease, but poses a significant risk of hepatotoxicity. Studying the ability of natural supplements like Ginger to counter the hepatotoxicity of INH may lead to a breakthrough in Tuberculosis treatment. The study aimed to investigate the protective effect of Zingiber officinale (Ginger) on isoniazid induced hepatotoxicity in albino rats as manifested by histomorphological changes. 

Methods: An experimental study was conducted over a period of six months on 40 adult albino rats .  The rats were divided by random sampling into four groups of ten each: Control group, Ginger group, INH group and INH+Ginger group. Rat livers were dissected and studied under light microscope for recording histomorphological changes. Data was analysed using IBM-SPSS version 23.0. 

Results: None of the specimens of the Control or Ginger groups (0%) showed any features of alteration in liver architecture. Periportal hepatitis was moderate in the INH group (90%) and mild in INH+Ginger group (90%). Confluent necrosis and focal and portal inflammation were present in both INH and INH+Ginger groups to varying degrees. Fibrosis was visible in 100% of the INH group versus only 10% of INH+Ginger group. Steatosis was found in 80% of the INH group versus only 10% of INH+Ginger group. All findings showed significant association between groups (p<0.001). 

Conclusion: Ginger has hepato-protective effects against INH-induced hepatotoxicity in male albino rats.

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