Siti Nuriah Mohd Noor, School of Dental Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
Marahaini Musa, Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
Ahmad Azlina, School of Dental Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
Siew Hua Gan, School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, 47500 Selangor Darul Ehsan, Malaysia
Kannan Thirumulu Ponnuraj, School of Dental Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, MalaysiaFollow

Sustaining the continuity of cells and their homeostasis throughout the lifespan is compulsory for the survival of an organism. Cellular senescence is one of mechanisms involved in cell homeostasis and survival, and plays both important and detrimental roles in the maintenance of malfunctioned and normal cells. However, when exposed to various insults (genetic, metabolic and environmental), the cells undergo oxidative stress which may induce premature senescence, or so-called stress-induced premature senescence. Many age-related diseases are associated with premature senescence. Hence, there is growing interest in the intake of natural sources such as dietary food, which has protective functions on human health and diseases as well as on premature senescence. There are many natural food sources which have beneficial effects on delaying cell senescence, of which bee products are one of them. Bee products (honey, propolis, royal jelly, bee pollen, bee bread, venom and wax) are rich in polyphenols, a compound that exerts powerful antioxidant actions against oxidative stress and is able to delay premature senescence that is linked to ageing. This review describes the factors triggering senescence, the biomarkers involved and the prevention of senescence by the polyphenols present in bee products. Thus, it is hoped that this will provide new insights into the clinical management of age-related diseases.

Keywords: Ageing; Cell senescence; Bee products; Polyphenols; Antioxidant

Noor, Siti Nuriah Mohd; Musa, Marahaini; Azlina, Ahmad; Gan, Siew Hua; and Ponnuraj, Kannan Thirumulu (2024) "Polyphenols in bee products and prevention of cell senescence," BioMedicine: Vol. 14 : Iss. 3 , Article 1.
DOI: 10.37796/2211-8039.1458