Verma A, Asivatham SJ, Deneke T, Castellvi Q, Neal RE 2nd. Primer on pulsed electrical field ablation: understanding the benefits and limitations. Circ Arrhythm Electrophysiol. 2021;14(9):e010086. https://doi.org/10.1161/CIRCEP.121.010086.

Article  PubMed  Google Scholar 

Zhang B, Liu F, Fang Z, Ding L, Moser MAJ, Zhang W. An in vivo study of a custom-made high-frequency irreversible electroporation generator on different tissues for clinically relevant ablation zones. Int J Hyperthermia. 2021;38(1):593–603. https://doi.org/10.1080/02656736.2021.1912417.

Article  PubMed  Google Scholar 

Dong S, Yao C, Zhao Y, Lv Y, Liu H. Parameters optimization of bipolar high frequency pulses on tissue ablation and inhibiting muscle contraction. IEEE Trans Dielectr Electr Insul. 2018;25(1):207–16. https://doi.org/10.1109/TDEI.2018.006303.

Article  Google Scholar 

García-Sánchez T, Amorós-Figueras G, Jorge E, et al. Parametric study of pulsed field ablation with biphasic waveforms in an in vivo heart model: the role of frequency. Circ Arrhythm Electrophysiol. 2022;15(10):e010992. https://doi.org/10.1161/circep.122.010992.

Article  PubMed  Google Scholar 

Yavin HD, Higuchi K, Sroubek J, Younis A, Zilberman I, Anter E. Pulsed-field ablation in ventricular myocardium using a focal catheter: the impact of application repetition on lesion dimensions. Circ Arrhythm Electrophysiol. 2021;14(9):e010375. https://doi.org/10.1161/circep.121.010375.

Article  PubMed  Google Scholar 

Wagstaff PG, de Bruin DM, van den Bos W, et al. Irreversible electroporation of the porcine kidney: temperature development and distribution. Urol Oncol. 2015;33(4):168 e1-7. https://doi.org/10.1016/j.urolonc.2014.11.019.

Article  PubMed  Google Scholar 

Bradley CJ, Haines DE. Pulsed field ablation for pulmonary vein isolation in the treatment of atrial fibrillation. J Cardiovasc Electrophysiol. 2020;31(8):2136–47. https://doi.org/10.1111/jce.14414.

Article  PubMed  Google Scholar 

Iyengar, SK, Iyengar S, Srivathsan, K. The promise of pulsed field ablation and the challenges ahead. Front Cardiovas Med. 2023;10:1235317. https://doi.org/10.3389/fcvm.2023.1235317.

Guo F, Wang J, Zhou L, Wang Y, Jiang H, Yu L. Advances in the application of pulsed field ablation for arrhythmia treatment. Cardiovasc Innov App. 2023;8(1):998. https://doi.org/10.15212/CVIA.2023.0019.

Ben-David E, Appelbaum L, Sosna J, Nissenbaum I, Goldberg SN. Characterization of irreversible electroporation ablation in in vivo porcine liver. Am J Roentgenol. 2012;198(1):W62–8. https://doi.org/10.2214/ajr.11.6940.

Article  Google Scholar 

Dunne E, Baena-Montes JM, Donaghey K, et al. A predictive and an optimization mathematical model for device design in cardiac pulsed field ablation using design of experiments. J Cardiovasc Dev Dis. 2023;10(10):423.

Gasperetti A, Assis F, Tripathi H, et al. Determinants of acute irreversible electroporation lesion characteristics after pulsed field ablation: the role of voltage, contact, and adipose interference. EP Europace. 2023;25(9). https://doi.org/10.1093/europace/euad257.

Yao C, Dong S, Zhao Y, et al. Bipolar microsecond pulses and insulated needle electrodes for reducing muscle contractions during irreversible electroporation. IEEE Trans Biomed Eng. 2017;64(12):2924–37. https://doi.org/10.1109/tbme.2017.2690624.

Neal RE, Garcia PA, Kavnoudias H, et al. In vivo irreversible electroporation kidney ablation: experimentally correlated numerical models. IEEE Trans Biomed Eng. 2015;62(2):561–9. https://doi.org/10.1109/TBME.2014.2360374.

Article  PubMed  Google Scholar 

Canvasser NE, Lay AH, Koseoglu E, et al. Effect of differing parameters on irreversible electroporation in a porcine model. J Endourol. 2018;32(4):338–43.

Bhonsle S, Bonakdar M, Neal RE, et al. Characterization of irreversible electroporation ablation with a validated perfused organ model. J Vasc Interv Radiol. 2016;27(12):1913–22.e2. https://doi.org/10.1016/j.jvir.2016.07.012.

Fang Z, Wei H, Zhang H, et al. Radiofrequency ablation for liver tumors abutting complex blood vessel structures: treatment protocol optimization using response surface method and computer modeling. Int J Hyperthermia. 2022;39(1):733–42. https://doi.org/10.1080/02656736.2022.2075567.

Article  PubMed  Google Scholar 

González-Suárez A, Pérez JJ, Berjano E. Should fluid dynamics be included in computer models of RF cardiac ablation by irrigated-tip electrodes? Biomed Eng Online. 2018;17(1):43. https://doi.org/10.1186/s12938-018-0475-7.

MIT. Steady ohmic conduction. Secondary Steady Ohmic Conduction. https://web.mit.edu/6.013_book/www/chapter7/7.2.html. Accessed 13 July 2024.

Pennes HH. Analysis of tissue and arterial blood temperatures in the resting human forearm. 1948. J Appl Physiol (1985). 1998;85(1):5–34. https://doi.org/10.1152/jappl.1998.85.1.5.

Article  PubMed  Google Scholar 

González-Suárez A, Irastorza RM, Deane S, O’Brien B, O’Halloran M, Elahi A. Full torso and limited-domain computer models for epicardial pulsed electric field ablation. Comput Methods Programs Biomed. 2022;221:106886. https://doi.org/10.1016/j.cmpb.2022.106886.

Article  PubMed  Google Scholar 

Hasgall P, Di Gennaro F, Baumgartner C, et al. IT’IS Database for thermal and electromagnetic parameters of biological tissues. Secondary IT’IS Database for thermal and electromagnetic parameters of biological tissues. https://www.itis.ethz.ch/database. Accessed 13 July 2024.

Barauskas R, Gulbinas A, Vanagas T, Barauskas G. Finite element modeling of cooled-tip probe radiofrequency ablation processes in liver tissue. Comput Biol Med. 2008;38(6):694–708. https://doi.org/10.1016/j.compbiomed.2008.03.007.

Article  PubMed  Google Scholar 

Zang L, Gu K, Ji X, Zhang H, Yan S, Wu X. Comparative analysis of temperature rise between convective heat transfer method and computational fluid dynamics method in an anatomy-based left atrium model during pulsed field ablation: a computational study. J Cardiovasc Dev Dis. 2023;10(2). https://doi.org/10.3390/jcdd10020056.

Zang L, Gu K, Ji X, Zhang H, Yan S, Wu X. Effect of anisotropic electrical conductivity induced by fiber orientation on ablation characteristics of pulsed field ablation in atrial fibrillation treatment: a computational study. J Cardiovasc Dev Dis. 2022;9:319. https://doi.org/10.3390/jcdd9100319.

Article  PubMed  PubMed Central  Google Scholar 

Fang Z, Li X, Yan S, et al. A novel polarity configuration for enhancing ablation depth of pulsed field ablation: design, modeling, and in vivo validation. Med Phys. 2023;50:5364–74. https://doi.org/10.1002/mp.16621.

Article  PubMed  Google Scholar 

Xu M, Song Z, Hong W, Wang L, Jiang C, Yang B, Qin M, Liu J. A high-precision, low-voltage pulsed field ablation device with capability of minimally invasive surgery. Adv Funct Mater. 2023;33:2302041. https://doi.org/10.1002/adfm.202302041.

Article  Google Scholar 

Wu C, Huang H, Liu Y, et al. Optimal design of aperiodic tri-slot antennas for the conformal ablation of liver tumors using an experimentally validated MWA computer model. Comput Methods Programs Biomed. 2023;242:107799. https://doi.org/10.1016/j.cmpb.2023.107799. [published Online First: Epub Date]|.

Kawamura I, Reddy VY, Wang BJ, et al. Pulsed field ablation of the porcine ventricle using a focal lattice-tip catheter. Circulation: Arrhythmia and Electrophysiology 2022;15(9):e011120

Lavee J, Onik G, Mikus P, Rubinsky B. A novel nonthermal energy source for surgical epicardial atrial ablation: irreversible electroporation. Heart Surg Forum. 2007;10(2):E162–7. https://doi.org/10.1532/HSF98.20061202. [published Online First: Epub Date]|.

Hong J, Stewart MT, Cheek DS, Francischelli DE, Kirchhof N. Cardiac ablation via electroporation. In: 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE. 2009. pp. 3381–3384.

Zager Y, Kain D, Landa N, Leor J, Maor E. Optimization of irreversible electroporation protocols for In-vivo myocardial decellularization. PLoS One. 2016;11(11):e0165475. https://doi.org/10.1371/journal.pone.0165475. [published Online First: Epub Date]|.

Faroja M, Ahmed M, Appelbaum L, et al. Irreversible electroporation ablation: is all the damage nonthermal? Radiology 2013;266(2):462–70.

Stewart MT, Haines DE, Verma A, et al. Intracardiac pulsed field ablation: proof of feasibility in a chronic porcine model. Heart Rhythm 2019;16(5):754–64. https://doi.org/10.1016/j.hrthm.2018.10.030. [published Online First: Epub Date]|.

Younis A, Buck E, Santangeli P, et al. Efficacy of pulsed field vs radiofrequency for the reablation of chronic radiofrequency ablation substrate: redo pulsed field ablation. JACC: Clin Electrophysiol. 2023. https://doi.org/10.1016/j.jacep.2023.09.015. [published Online First: Epub Date]|.

Mercadal B, Arena CB, Davalos RV, Ivorra A. Avoiding nerve stimulation in irreversible electroporation: a numerical modeling study. Physics in Medicine & Biology 2017;62(20):8060

Miklavcic D, Pucihar G, Pavlovec M, et al. The effect of high frequency electric pulses on muscle contractions and antitumor efficiency in vivo for a potential use in clinical electrochemotherapy. Bioelectrochemistry 2005;65(2):121–8. https://doi.org/10.1016/j.bioelechem.2004.07.004. [published Online First: Epub Date]|.

Fusco R, Di Bernardo E, D'Alessio V, Salati S, Cadossi M. Reduction of muscle contraction and pain in electroporation-based treatments: an overview. World Journal of Clinical Oncology 2021;12(5):367.

Arena CB, Sano MB, Rossmeisl JH, et al. High-frequency irreversible electroporation (H-FIRE) for non-thermal ablation without muscle contraction. BioMed Eng OnLine. 2011;10(1):102. https://doi.org/10.1186/1475-925X-10-102. [published Online First: Epub Date]|.

Ye X, et al. Study on optimal parameter and target for pulsed-field ablation of atrial fibrillation. Front Cardiovas Med. 2021;8. https://doi.org/10.3389/fcvm.2021.690092.

Mattison L, Verma A, Tarakji KG, Reichlin T, Hindricks G, Sack KL, Önal B, Schmidt MM, Miklavčič  D, Sigg DC. Effect of contact force on pulsed field ablation lesions in porcine cardiac tissue. Abstract Journal of Cardiovascular Electrophysiology 2023;34(3):693–9. https://doi.org/10.1111/jce.15813.

Targeted Tissue Ablation With Nanosecond Pulses. IEEE Transactions on Biomedical Engineering 2011;58(8):2161–7. https://doi.org/10.1109/TBME.2011.2113183.

Cardiac ablation with pulsed electric fields: principles and biophysics. Abstract EP Europace 2022;24(8):1213–22. https://doi.org/10.1093/europace/euac033.