Styczyński J, Tridello G, Koster L, Iacobelli S, van Biezen A, van der Werf S, et al. Death after hematopoietic stem cell transplantation: changes over calendar year time, infections and associated factors. Bone Marrow Transpl. 2020;55:126–36.

Article  Google Scholar 

Rackley C, Schultz KR, Goldman FD, Chan KW, Serrano A, Hulse JE, et al. Cardiac manifestations of graft-versus-host disease. Biol Blood Marrow Transplant. 2005;11:773–80.

Article  PubMed  Google Scholar 

Nassiri N, Eslani M, Panahi N, Mehravaran S, Ziaei A, Djalilian AR. Ocular graft versus host disease following allogeneic stem cell transplantation: a review of current knowledge and recommendations. J Ophthalmic Vis Res. 2013;8:351–8.

PubMed  PubMed Central  Google Scholar 

Nassar A, Tabbara KF, Aljurf M. Ocular manifestations of graft-versus-host disease. Saudi J Ophthalmol. 2013;27:215–22.

Article  PubMed  PubMed Central  Google Scholar 

Goker H, Haznedaroglu IC, Chao NJ. Acute graft-vs-host disease: pathobiology and management. Exp Hematol. 2001;29:259–77.

Article  CAS  PubMed  Google Scholar 

Min CK. The pathophysiology of chronic graft-versus-host disease: the unveiling of an enigma. Korean J Hematol. 2011;46:80–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Soleimani M, Mahdavi Sharif P, Cheraqpour K, Koganti R, Masoumi A, Baharnoori SM, et al. Ocular graft-versus-host disease (oGVHD): from A to Z. Surv Ophthalmol. 2023;68:697–712.

Article  PubMed  PubMed Central  Google Scholar 

Saboo US, Amparo F, Shikari H, Dana R. Prevalence of ocular hypertension and glaucoma in patients with chronic ocular graft-versus-host disease. Graefes Arch Clin Exp Ophthalmol. 2016;254:923–8.

Article  PubMed  PubMed Central  Google Scholar 

Sinha S, Singh RB, Dohlman TH, Taketani Y, Yin J, Dana R. Prevalence and risk factors associated with corneal perforation in chronic ocular graft-versus-host-disease. Cornea. 2021;40:877.

Article  PubMed  Google Scholar 

Cheng X, Huang R, Huang S, Fan W, Yuan R, Wang X, et al. Recent advances in ocular graft-versus-host disease. Front Immunol. 2023;14:1092108.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ocular instillation of vitamin A–coupled liposomes containing HSP47 siRNA ameliorates dry eye syndrome in chronic GVHD - PMC [Internet]. [cited 2024 Jun 30]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457226/

Yaguchi S, Ogawa Y, Shimmura S, Kawakita T, Hatou S, Satofuka S, et al. Angiotensin II Type 1 receptor antagonist attenuates lacrimal gland, lung, and liver fibrosis in a murine model of chronic graft-versus-host disease. PLoS ONE. 2013;8:e64724.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ogawa Y, Dogru M, Uchino M, Tatematsu Y, Kamoi M, Yamamoto Y, et al. Topical tranilast for treatment of the early stage of mild dry eye associated with chronic GVHD. Bone Marrow Transpl. 2010;45:565–9.

Article  CAS  Google Scholar 

Yamane M, Sato S, Shimizu E, Shibata S, Hayano M, Yaguchi T, et al. Senescence-associated secretory phenotype promotes chronic ocular graft-vs-host disease in mice and humans. FASEB J. 2020;34:10778–800.

Article  CAS  PubMed  Google Scholar 

Lasagni Vitar RM, Bonelli F, Atay A, Triani F, Fonteyne P, Di Simone E, et al. Topical neurokinin-1 receptor antagonist Fosaprepitant ameliorates ocular graft-versus-host disease in a preclinical mouse model. Exp Eye Res. 2021;212:108825.

Article  CAS  PubMed  Google Scholar 

Complement and CD4+ T cells drive context-specific corneal sensory neuropathy - PMC [Internet]. [cited 2024 Jun 30]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783265/

Tovar AA, White IA, Sabater AL. Use of acellular umbilical cord-derived tissues in corneal and ocular surface diseases. Medicines. 2021;8:12.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sanchez-Avila RM, Merayo-Lloves J, Muruzabal F, Orive G, Anitua E. Plasma rich in growth factors for the treatment of dry eye from patients with graft versus host diseases. Eur J Ophthalmol. 2020;30:94–103.

Article  PubMed  Google Scholar 

Diaz-Valle D, Burgos-Blasco B, Rego-Lorca D, Puebla-Garcia V, Perez-Garcia P, Benitez-del-Castillo JM, et al. Comparison of the efficacy of topical insulin with autologous serum eye drops in persistent epithelial defects of the cornea. Acta Ophthalmol. 2022;100:e912–9.

Article  CAS  PubMed  Google Scholar 

Sun YC, Inamoto Y, Wang RK, Lee SJ, Hung KF, Shen TT. The disposable bandage soft contact lenses therapy and anterior segment optical coherence tomography for management of ocular graft-versus-host disease. BMC Ophthalmol. 2021;21:271.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bae SS, Iovieno A, Yeung SN. Outcomes of scleral lenses for dry eye disease in chronic ocular graft-versus-host disease. Cont Lens Anterior Eye. 2023;46:101721.

Article  PubMed  Google Scholar 

Ikarashi H, Aketa N, Shimizu E, Takano Y, Kawakita T, Uchino Y, et al. Two case reports of continued progression of chronic ocular graft-versus-host disease without concurrent systemic comorbidities treated by amniotic membrane transplantation. BMC Ophthalmol. 2021;21:164.

Article  PubMed  PubMed Central  Google Scholar 

Mukai S, Ogawa Y, Kawakami Y, Mashima Y, Tsubota K. Inhibition of vascular adhesion protein-1 for treatment of graft-versus-host disease in mice. FASEB J. 2018;32:4085–95.

Article  CAS  PubMed  Google Scholar 

Gilger BC, Hirsch ML. Therapeutic applications of Adeno-Associated Virus (AAV) gene transfer of HLA-G in the eye. Int J Mol Sci. 2022;23:3465.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xue E, Lorentino F, Pavesi F, Assanelli A, Peccatori J, Bernardi M, et al. Ruxolitinib for chronic steroid-refractory graft versus host disease: a single center experience. Leuk Res. 2021;109:106642.

Article  CAS  PubMed  Google Scholar 

Zeiser R, Polverelli N, Ram R, Hashmi SK, Chakraverty R, Middeke JM, et al. Ruxolitinib for glucocorticoid-refractory chronic graft-versus-host disease. N. Engl J Med. 2021;385:228–38.

Article  CAS  PubMed  Google Scholar 

Zhou T, He C, Lai P, Yang Z, Liu Y, Xu H, et al. miR-204–containing exosomes ameliorate GVHD-associated dry eye disease. Science Advances [Internet]. 2022;8 [cited 2024 Jun 30] Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8754411/

Yamane M, Ogawa Y, Fukui M, Kamoi M, Uchino M, Saijo-Ban Y, et al. Long-term topical diquafosol tetrasodium treatment of dry eye disease caused by chronic graft-versus-host disease: a retrospective study. Eye Contact Lens. 2018;44:S215–20.

Article  PubMed  Google Scholar 

Chhabra S, Jerkins JH, Conto JE, Zellner K, Shah NN, Hari PN, et al. Lifitegrast ophthalmic solution for treatment of ocular chronic graft-versus-host disease. Leuk Lymphoma. 2020;61:869–74.

Article  CAS  PubMed  Google Scholar 

Study Details | Study for the Treatment of Ocular Chronic Graft-Versus-Host Disease (GVHD) With Amniotic Fluid Eye Drops (AFED) | ClinicalTrials.gov [Internet]. [cited 2024 Jul 6]. Available from: https://clinicaltrials.gov/study/NCT03298815?id=%22NCT01972438%22OR%22NCT03298815%22&rank=1

Study Details | Vigamox Treatment for Ocular Graft-Versus-Host Disease | ClinicalTrials.gov [Internet]. [cited 2024 Jul 6]. Available from: https://clinicaltrials.gov/study/NCT04204122

Study Details | Study of Brimonidine Tartrate Nanoemulsion Eye Drops in Patients With Ocular Graft-vs-Host Disease | ClinicalTrials.gov [Internet]. [cited 2024 Jul 6]. Available from: https://clinicaltrials.gov/study/NCT03591874?cond=NCT03591874&rank=1

Study Details | Effect of UMSCs Derived Exosomes on Dry Eye in Patients With cGVHD | ClinicalTrials.gov [Internet]. [cited 2024 Jul 6]. Available from: https://clinicaltrials.gov/study/NCT04213248?cond=NCT04213248&rank=1