Document Type : original article

Authors

1 USERN Office, Lorestan University of Medical Sciences, Khorramabad, Iran Student Research committee, Lorestan University of Medical Sciences, Khorramabad, Iran

2 Master Health Education, Ilam University of Medical Sciences, Ilam, Iran

3 Department of Pediatric, Clinical Research Development Center of Children Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

4 Department of Pediatrics, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

5 Bachelor of Nursing Student, scientific Research of Committee, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran

6 Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran

7 Department of Pediatric Oncology, pediatric Hospital, GolShahr, Bandar Abbas, Iran

10.22038/ijp.2024.79640.5451

Abstract

Background: Based on the findings of the publications, patients with severe Covid-19 have a much greater occurrence of coagulation abnormalities. Additionally, individuals who get this novel virus are susceptible to developing disseminated intravascular coagulation. The present study aimed to investigate the prevalence of coagulation disorders in children with covid-19 who were hospitalized in Bandar Abbas Children's Hospital in 2020-2021.

Methods: This study was done retrospectively. The medical records of all children admitted to Bandar Abbas Children's Hospital in 2020 were checked with a definite diagnosis of Covid, based on positive PCR results. Age, gender and comorbidity status were obtained from the medical records of the patients. In addition, white blood cell count, blood platelet count, hemoglobin concentration, CRP, PT, PTT, INR, D-dimer and fibrinogen. data collected using SPSS26 software with a significance threshold of 0.05 were analyzed and was analyzed

Results: In this study 20.00% had coagulation abnormalities. The groups with and without coagulation disease exhibited a significant difference in the proportions of neutrophils and lymphocytes. Specifically, the coagulation disorder group had elevated levels of neutrophils and reduced levels of lymphocytes (P= 0.043, P= 0.041, respectively). The average D-dimer level in the group with coagulation disorder was significantly greater than in the group without coagulation problem (P= 0.00).

Conclusion: According to the findings of this research, 20% of children who were definitively diagnosed with covid-19 had coagulation abnormalities. Only the alterations in D-dimer, lymphocyte, and neutrophil levels were shown to be substantially associated with coagulation disorders in this investigation. Specifically, in the group with coagulation disorders, there was an elevation in neutrophil count and a decrease in lymphocyte count.

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