Background: Color vision deficiency (CVD) is a common congenital ophthalmic disease, and no effective therapeutic measures are currently available for this patient population. This study aimed to explore the efficacy of photobiomodulation (PBM) in CVD patients. Methods: A randomized controlled trial design was applied in this study, whereby 80 patients with red-green CVD were randomly divided into PBM treatment and control groups. Color vision was assessed after 1, 2, and 4 weeks of treatment. Statistical analysis of treatment was carried out using the Kruskal-Wallis test with Dunn's test for multiple comparisons using SPSS and R software. Findings: Compared to the control group, the color vision of CVD patients exhibited a significant improvement in the PBM treatment group for different parameters (Ps＜0.05). Interpretation: PBM therapy could significantly improve color vision in patients with congenital CVD, especially in patients with green CVD.

The authors have declared no competing interest.

ChiCTR2200056761

This study did not receive any funding.

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The ethics committee of PLA General Hospital gave ethical approval for this work

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