Harnessing the versatility of hydrazones through electrosynthetic oxidative transformations

Introduction

Hydrazones represent an important class of organic compounds. They can be readily prepared through the condensation of hydrazine derivatives with aldehydes or ketones. They have found widespread applications in materials sciences and supramolecular chemistry . Importantly, they are versatile reagents in organic synthesis. They have for instance been frequently employed for the construction of azacycles through various cyclization protocols or cycloaddition reactions . Early work in this field includes the well-known Fischer indole synthesis . Additionally, they have been harnessed as valuable intermediates in Wolff–Kishner reduction reactions or for the synthesis of various olefins via diazo or vinyllithium intermediates in the Bamford–Stevens reaction and Shapiro reaction , respectively . SAMP/RAMP ((S)/(R)-1-amino-2-methoxymethylpyrrolidine)hydrazones could be also key intermediates for the asymmetric synthesis of α-substituted aldehydes and ketones . Interestingly, depending on the substitution pattern, the C=N bond can feature different electronic properties . For instance, various hydrazones have been employed for the asymmetric preparation of chiral amines through the addition of nucleophilic partners while the azaenamine character of some aldehyde-derived hydrazones has been demonstrated in the coupling with suitable electrophiles such as Michael acceptors . Last but not least, the C=N bond of hydrazones can act as radical acceptors for the synthesis of functionalized amines or hydrazones through reductive functionalization or oxidative C(sp2)–H functionalization , respectively. Consequently, given their rich reactivity profile, exploring new synthetic transformations of hydrazones is of significant importance and can contribute to the formation of novel organic compounds.

Electrosynthesis enables the generation of either radical, radical ionic or ionic species under mild and environmentally friendly reaction conditions . The direct use of electrical current to drive oxidative and reductive processes precludes the reliance on toxic or dangerous redox reagents . The explosive renewal of interest in this technology and the resulting recent achievements have brought it at the forefront of organic synthesis. Electrooxidative transformations of hydrazones offer appealing opportunities to take advantage of the versatility of this reagent. Such an approach can either ameliorate the previous methods in a more sustainable and efficient fashion or provide a mean for the discovery of new reactivity. Herein, this review aims to give an overview of the state of the art in the electrochemical oxidative transformations of hydrazones. It is organized in four main parts: (i) synthesis of azacycles, (ii) synthesis of functionalized hydrazones through C(sp2)–H functionalization of aldehyde-derived hydrazones, (iii) access to diazo compounds, and (iv) synthesis of miscellaneous compounds. For reactions carried out under constant current electrolysis, the reported current applied (in A or mA) is depicted. Additionally, when possible, and for better accuracy, the current density (in mA·cm−2) has been calculated based on the size of the electrode portion immersed in the solution, as described in the experimental section. This information is provided in brackets.

Review Synthesis of azacycles

Nitrogen-containing heterocyclic compounds possess numerous applications in various domains such as materials science, agrochemistry and medicinal chemistry. Especially, 60% of all FDA-approved drugs in the United States contain at least one azacycle . Therefore, the development of gentle and efficient methods for accessing these heterocycles is an ongoing pursuit for synthetic chemists. As mentioned above, with their two nitrogen atoms, hydrazones constitute unique synthons for constructing azacycles. Resorting to electrochemical approaches furnishes original compounds. Although the first report dates back to 1974, this tool has only been seriously considered in the last 15 years.

Oxidative cyclization of hydrazones

In 1974, Tabaković et al. published the oxidative cyclization of 2-acetylpyridine-derived N-phenylhydrazone 1a to form triazolopyridinium salt 2a . The process was further applied to various 2-acetylpyridine and 2-benzoylpyridine derivatives (Scheme 1) . The corresponding pyridinium salts 2 were obtained in high yields when the electrolysis was conducted in a divided cell under potentiostatic conditions at 1.2–1.65 V vs SCE in acetonitrile.

Scheme 1: Synthesis of triazolopyridinium salts .

In 1976, the same group reported the anodic cyclization of chalcone-derived N-phenylhydrazone 3 to pyrazole 4 in a divided cell at constant current (Scheme 2) . The obtained poor yield was explained by the formation of dimeric side products. Cyclic voltammetry analysis suggested an initial anodic single electron transfer (SET) to radical cation 5, cyclization and deprotonation. Subsequent SET oxidation in solution by 5 led to cation 7. Final deprotonation furnished aromatic cycle 4.

Scheme 2: Synthesis of pyrazoles .

In 2022, Zhang et al. documented the synthesis of 1H-indazoles 9 via the electrooxidative cyclization of (hetero)aromatic ketones-derived N-phenylhydrazones 8 (Scheme 3) . In contrast with the above-mentioned works, the electrolysis was carried out in an undivided cell under galvanostatic conditions. High yields were obtained regardless of the electronic properties of the substituents on the N-phenyl ring. When dissymmetric diaryl ketone-derived substrates were employed, the C–N bond formation occurred selectively on the most electron rich aromatic ring. According to the proposed mechanism, this dehydrogenative cyclization of hydrazones initiated with the SET anodic oxidation of the hydrazone and deprotonation to form the N-centered radical 10. After aza-cyclization on the aromatic ring, a second SET oxidation and deprotonation delivered the heterocycle 9. This mechanism was supported by cyclic voltammetry analysis of a model substrate (1-(diphenylmethylene)-2-(4-nitrophenyl)hydrazine), which displayed three oxidation peaks (0.9, 1.7 and 2.2 V vs Ag+/Ag in HFIP ). The authors assumed that the two first peaks would correspond to the oxidation of 8 to 10 and 11 to 12 and that the oxidation of 10 would be responsible for the final one, which is consistent with the finding of ketone side-product.

Scheme 3: Synthesis of indazoles from ketone-derived hydrazones .

In 2018, the group of Zhang established an intramolecular C(sp2)–H functionalization of aldehyde-derived N-(2-pyridinyl)hydrazones 15 to produce 1,2,4-triazolo[4,3-a]pyridines 16 (Scheme 4) . Interestingly, the hydrazone was in situ prepared prior to the electrolysis through the condensation of 2-hydrazinopyridine 13 and various aromatic, aliphatic and α,β-unsaturated aldehydes 14. The electrooxidative transformation was performed under constant current at 7 mA in a mixture of acetonitrile and water under heating. From a mechanistic point of view, the authors proposed the formation of N-pyridyl radical 18 through the anodic oxidation of in situ-generated anion 17. Subsequent radical cyclization, second anodic cyclization and deprotonation yielded the fused heterocycle 16.

Scheme 4: Intramolecular C(sp2)–H functionalization of aldehyde-derived N-(2-pyridinyl)hydrazones for the synthesis of 1,2,4-triazolo[4,3-a]pyridines .

Scheme 5: Synthesis of pyrazolo[4,3-c]quinoline derivatives .

In 1992, Chiba and Okimoto reported the electrooxidative cyclization of aldehyde and ketone-derived N-acylhydrazones 23a and 23b to build 1,3,4-oxadiazoles 24a and Δ3-l,3,4-oxadiazolines 24b, respectively. Using sodium methoxide as basic supporting electrolyte in a divided cell equipped with carbon rod anodes and a platinium coil cathode, the transformation would involve cyclization of carbocationic species 25 to form the intermediate 26. From 23a (R2 = H), the latter would undergo deprotonation delivering the oxadiazole 24a. Alternatively, from 23b (R2 ≠ H), nucleophilic addition of methanol to oxycarbenium 26b yielded the oxadiazoline 24b (Scheme 6) .

Scheme 6: Synthesis of 1,3,4-oxadiazoles and Δ3-1,3,4-oxadiazolines .

In 2020, Lei, Zhang and Gao et al. described the electrooxidative cyclization of in situ-generated α-keto acid-derived NH-acylhydrazones to build 1,3,4-oxadiazole derivatives in good yields. The electrolysis was conducted under galvanostatic conditions in methanol using a carbon graphite anode and a platinum cathode. From a mechanistic point of view, in situ condensation of acylhydrazines 28 with α-keto acids 27 produced hydrazones 29. After deprotonation, the authors proposed that the carboxylate anion underwent SET anodic oxidation/decarboxylation/radical cyclization sequence to form radical intermediates 34. Subsequent second anodic oxidation and deprotonation yielded the desired heteroaromatic 5-membered rings 30. Importantly, a control experiment using benzaldehyde-derived N-benzoylhydrazone delivered the corresponding 1,3,4-oxadiazole in only 25% yield. This result indicates that benzaldehyde-derived hydrazone is a less probable reaction intermediate, thereby supporting the proposed mechanism (Scheme 7) .

Scheme 7: Synthesis of 1,3,4-oxadiazoles .

In parallel, Sheng and Zhang et al. found that 2-(1,3,4-oxadiazol-2-yl)aniline derivatives 38 could be electrochemically synthesized from isatins 35 and acylhydrazine 36. The transformation was carried out in an undivided cell at high temperature in DMSO using potassium iodide as supporting electrolyte with potassium carbonate as a base and two platinum electrodes. Mechanistically, condensation of the two reactants formed isatin-derived acylhydrazone 37. Hydrolysis of the latter in the presence of the inorganic base gave rise to potassium carboxylate 39. Meanwhile, two consecutive SET oxidations of the iodide anion generated molecular iodine which reacted with 39 to furnish unstable hypoiodous anhydride 40, thereby triggering the key CO2 extrusion. The resulting C(sp2)-centered radical 42 underwent a SET anodic oxidation/cyclization/deprotonation sequence to yield the oxadiazole derivative 38. As such, the iodide electrolyte served as an electromediator to both promote the decarboxylation process and protect the aniline product from overoxidation. Importantly, a control experiment without electricity but in the presence of molecular iodine instead proceeded smoothly, thereby confirming the critical role of in situ-generated molecular iodine (Scheme 8) .

Scheme 8: Synthesis of 2-(1,3,4-oxadiazol-2-yl)anilines .

Formal cycloaddition

Hydrazones constitute a versatile building block for the construction of azacycles through formal cycloaddition reactions. Under oxidative electrochemical conditions, either the oxidation of the hydrazone or the partner might be investigated offering numerous possibilities for the assembly of heterocycles.

As early as 1988, Tabaković and Gunić examined the anodic oxidation of aldehyde-derived NH-arylhydrazones 44 in the presence of pyridine and (iso)quinolone derivatives 45 in acetonitrile-tetraethylammonium perchlorate solution under constant potential in a divided cell equipped with platinum gauze anode and nickel cathode. Such a transformation constituted a straightforward route to the corresponding fused s-triazolo perchlorates 46 in moderate to high yield. Coulometric analysis established that the electrolysis was a four-electron oxidative process. Based on this study, the authors proposed the initial anodic oxidation of hydrazone 44 through the loss of two electrons and one proton to form cation 47. Subsequent nucleophilic addition of the azaarene led to new highly acidic cationic species 48. The latter underwent deprotonation and cyclization to form fused system 49. Final two-electron oxidation and deprotonation delivered the ionic product 46 (Scheme 9) .

Scheme 9: Synthesis of fused s-triazolo perchlorates .

For the construction of non-ionic azacycle from aldehyde-derived NH-arylhydrazones, the electrolysis is generally conducted in the presence of iodide anion as electromediator. An important challenge is to avoid the competitive formation of the corresponding methoxy(phenylazo)alkane or carbonyl compound upon SET anodic oxidation of the hydrazone and subsequent reaction with methanol or water, respectively. In 2018, Yuan and Yang developed a multicomponent synthesis of 1-aryl and 1,5-disubstitued 1,2,4-triazoles using tetrabutylammonium iodide as electromeditor . 1-Methylene-2-arylhydrazine 52 was in situ generated through the condensation of paraformaldehyde 51 with arylhydrazines 50, while the electrolyte ammonium acetate and the alcoholic solvent acted as N and C1 sources, respectively. The authors proposed the mechanism depicted in Scheme 10. The deprotonation of hydrazone 52 afforded anion 54 which underwent SET anodic oxidation to form radical 55. In parallel, an elusive oxidation of alcohol electromediated by iodine would furnish aldehyde 56. Electrogenerated iodine would further assist the reaction with ammonia to form N-iodo aldimine intermediate 57. Subsequent radical cycloaddition between 56 and 57 would furnish cyclic hydrazinyl radical 58. Finally, the triazole would be obtained after hydrogen atom abstraction by iodide radical and deprotonation.

Scheme 10: Synthesis of 1-aryl and 1,5-disubstitued 1,2,4-triazoles .

Inspired by these works, Li and Gu et al. proposed the electrosynthesis of 1,3,5-trisubstituted 1,2,4-triazoles from preformed aldehyde-derived N-arylhydrazones 60, aldehydes 61 and ammonium acetate. Herein, the authors suggested the electromediated oxidation of N-arylhydrazone by electrogenerated iodide radical (Scheme 11) .

Scheme 11: Synthesis of 1,3,5-trisubstituted 1,2,4-triazoles .

In parallel, the group of Yuan achieved the electrosynthesis of 1,3,5-trisubstituted 1,2,4-triazoles 67 from arylhydrazines 64, aldehydes 65 and primary amines 66. Iodine-mediated electrooxidation of in situ-generated aldehyde-derived hydrazones was also proposed as key initial step of the transformation (Scheme 12) . Concurrently, similar formal electrochemical cycloaddition reactions between preformed aldehyde-derived hydrazones and aliphatic amines were investigated by the groups of D. Tang and Pan . The latter employed ferrocene as electrocatalyst instead of iodide salts. Additionally, Tang et al. demonstrated that amidines could react with preformed aldehydes-derived hydrazones to produce similar 1,3,5-trisubstituted 1,2,4-triazoles .

Scheme 12: Alternative synthesis of 1,3,5-trisubstituted 1,2,4-triazoles .

The last example of electrochemical synthesis of trisubstituted 1,2,4-triazoles was accomplished by D. Tang et al. through the formal cycloaddition between in situ-generated aldehyde-derived hydrazones and cyanoamine (70). The 5-amino derivatives 71 were obtained in moderate to good yields by employing potassium iodide as electrocatalyst (Scheme 13) . Herein, the electrochemical approach constitutes an advantageous alternative to previous methods, which required the preparation of difficult-to-handle hydrazonoyl halides for the synthesis of 1-aryl-5-amino-1,2,4-triazoles from cyanamide .

Scheme 13: Synthesis of 5-amino 1,2,4-triazoles .

Pyrazolines are highly important heterocyclic motifs in pharmaceutical and agrochemical industries. The (3 + 2)-cycloaddition between nitrile imines and alkenes represents one of the most efficient strategies to prepare these azacycles. However, conventional methods for the generation of the nitrile imine involved the use of unstable hydrazonoyl halides or the oxidation of aldehyde-derived hydrazones under harsh reaction conditions. In 2023, the group of Waldvogel presented a formal electrooxidative (3 + 2)-cycloaddition between aldehyde-derived hydrazones 72 and alkenes 73 to yield a large range of N-arylpyrazolines 74 under mild reaction conditions (Scheme 14) . A biphasic system (aqueous/organic) was engineered during which the oxidation of the iodide mediator took place in the aqueous place, thereby protecting sensitive dipolarophiles such as styrenes from side reactions (e.g., overoxidation or polymerisation) in the organic phase. Ethyl acetate was employed as organic solvent for ethyl glyoxylate phenylhydrazone 72a while methyl tert-butyl ether was preferred for aromatic and aliphatic aldehyde-derived hydrazones 72b. Styrenes, enamines as well as electron poor aliphatic alkenes were all suitable dipolarophiles. From a mechanistic point of view, the authors proposed the electrogeneration of iodine in the aqueous phase. Under high stirring, the latter would react with NH-arylhydrazones 72 in the organic phase to furnish the N-iodo hydrazonium 75 and ultimately the nitrile imine 76 under basic conditions provided by the cathodic process. The critical role of the in situ cathodic generation of the base was supported by a control experiment in a divided cell, where no conversion was achieved. Final formal (3 + 2)-cycloaddition with the dipolarophiles 73 delivered the pyrazolines 74. It is interesting to note that a complementary (3 + 2)-cycloaddition between aldehyde hydrazones and alkenes for the preparation of pyrazolines was proposed by Tong, Song, et al., achieving similar efficiency using oxone/KBr as an environmentally friendly oxidative system .

Scheme 14: Synthesis of 1-arylpyrazolines .

Most recently, Zhou and Ma et al. described the electrochemical access to 3‑aminopyrazoles 79 from arylpropynal-derived NH-arylhydrazones 77 and secondary amines 78 in moderate to good yields. Potassium iodide was employed as electrolyte and mediator in ethanol in an undivided cell equipped with a carbon graphite and a platinium cathode. The transformation initiated with the electrochemical generation of iodonium through a two-electron process. Subsequent reaction with the hydrazone and deprotonation formed the N-iodo hydrazone intermediate 80, triggering the reaction with the amine 78 through cationic species 81. Final cyclization delivered the desired pyrazole 79 (Scheme 15) .

Scheme 15: Synthesis of 3‑aminopyrazoles .

The group of D. Tang engaged aromatic aldehyde-derived NH-tosylhydrazones 83 in an iodide-catalyzed electrochemical formal (3 + 2)-cycloaddition with quinolines 84 to build [1,2,4]triazolo[4,3-a]quinoline derivatives 85. Better yields were obtained with hydrazones bearing an electron-rich substituent on the aromatic ring. The reaction initiated with anodic formation of iodine. The latter would react with hydrazone 83 to form the zwitterionic species 86 under basic conditions. Subsequent formal (3 + 2)-cycloaddition with the quinoline 84 formed fused system 87 which underwent elimination of iodide and sulfinic acid to furnish the aromatic product 85, thereby regenerating the catalyst (Scheme 16) .

Scheme 16: Synthesis of [1,2,4]triazolo[4,3-a]quinolines .·

Given its abundance, stability, and low price, elemental sufur (S8) is an ideal source of sulfur atom to produce thiacycles . In 2019, H.-T. Tang utilized this reagent in combination with (hetero)aromatic ketone-derived NH-tosylhydrazones 89 for the electrochemical construction of 1,2,3-thiadiazoles 91. The electrolysis was conducted in an undivided cell at high temperature using ammonium iodide as electrocatalyst. Interestingly, no additional electrolyte was required. The transformation accommodated various substituents on the aromatic moiety regardless of their electronic properties. However, 4,5-disubstituted 1,2,3-thiadiazoles could not be accessed with this methodology. Mechanistically, control experiments with radical trapping agent such as TEMPO ((2,2,6,6-tetramethylpiperidin-1-yl)oxyl) or 1,1-diphenylethylene proceeded with similar efficiency, thereby excluding any radical pathway. As such, it was proposed that the catalytic electrooxidation of iodide (ENH4I = 0.41 V and 0.75 V vs Ag/AgCl in dimethylacetamide for I−/I3− and I3−/I2 redox couples) into iodine provided a green and mild tool to in situ generate the α-iodo ketone-derived NH-tosylhydrazone 92 and ultimately the azadiene 93 upon elimination of HI. In agreement with a previous report , further formal (4 + 1) cycloaddition with S8 followed by elimination of S7 and sulfinic acid gave rise to the aromatic cycle 91 (Scheme 17) .

Scheme 17: Synthesis of 1,2,3-thiadiazoles .

The direct C(sp2)–H functionalization of aldehyde-derived N,N-dialkylhydrazones has been also explored for constructing various azacycles. In 2021, the group of Ruan and Feng studied the electrochemical C(sp2)–H thiocyanation of aldehyde-derived N,N-dialkylhydrazones 95 with sodium thiocyanate (96) to prepare 5-thioxo-1,2,4-triazolium inner salts 97. The electrolysis was conducted with two inexpensive graphite electrodes in the absence of additional supporting electrolyte. It could be easily performed on a gram scale, albeit with a slight decrease in the efficiency. It was compatible with a large array of aromatic aldehyde-derived hydrazones regardless of their electronic properties as well as aliphatic-aldehyde derived hydrazones. Cyclic voltammetry analysis showed that thiocyanate salt 96 possesses a lower oxidation potential than the hydrazone 95. As such, the authors proposed the anodic generation of electrophilic thiocyanogen as the initial step. Further reaction with the hydrazone 95 and deprotonation led to hydrazonoyl thiocyanate intermediate 99, which isomerized to the thermodynamically more stable isothiocyanate derivatives 100 through 1,3-shift. The latter underwent spontaneous ring closure to furnish the 1,2,4-triazolium 97 (Scheme 18) .

Scheme 18: Synthesis of 5-thioxo-1,2,4-triazolium inner salts .

In the last example of this section, only one nitrogen atom of the hydrazone takes part in the cycloaddition reaction. In 2018, Zhang et al. realized the electrochemical (3 + 2)-cycloaddition of trimethylsilyl azide (102) with aldehyde-derived N,N-disubstituted hydazones 101 for synthesiszing tetrazoles 103. Sodium azide could be an alternative source of azide, albeit with both slightly lower yields and Faradic efficiency. Remarkably, (hetero)aromatic as well as aliphatic aldehydes proved to be efficient. Various substituents on the N(sp3) atom were well tolerated and the best result was obtained with a morpholine ring. Based on cyclic voltammetry studies, the transformation initiated with the anodic oxidation of hydrazone 101 to form highly electrophilic radical cationic species 104. Subsequent addition of azide 102 and desilylation formed hydrazinyl radical 105 which underwent second anodic oxidation/cyclization and deprotonation sequence to build the 1-aminotetrazole 103 (Scheme 19) . It is interesting to note that this mechanism differs from the one proposed by Zhu et al., who reported a hypervalent iodide-mediated similar cycloaddition through the generation of azide radical, although with similar yields .

Scheme 19: Synthesis of 1-aminotetrazoles .

Synthesis of functionalized hydrazones through C(sp2)–H functionalization of aldehyde-derived hydrazones

The direct electrochemical C(sp2)–H functionalization of aldehyde-derived N,N-disubstituted hydrazones provides an efficient tool for accessing various hydrazones under mild reaction conditions and, to some extent, broadening the scope of more conventional radical approaches. Typically, two mechanistic pathways can be proposed depending on the oxidation potentials of each partner. If the hydrazone is the most readily species to be oxidized, initial SET anodic oxidation of the hydrazone furnishes the highly electrophilic radical cation species D, which undergo nucleophilic addition of the second partner and deprotonation to produce hydrazinyl radical F (route a). Alternatively, if the partner possesses a lower oxidation potential than the hydrazone, then the transformation initiates with the anodic generation of radical species Y•, that adds to the hydrazone leading ultimately to hydrazinyl radical F as well (route b). In both cases, a second SET anodic oxidation and deprotonation yields the functionalized hydrazone (Scheme 20).

Scheme 20: C(sp2)–H functionalization of aldehyde-derived hydrazones: general mechanisms.

Initial SET oxidation of the hydrazone

In 1973, Barbey and Caullet have shown that the benzaldehyde-derived N,N-diphenylhydrazone 107 dimerized upon electrochemical oxidation on platinum electrode . The following year, they demonstrated that in the presence of an excess of pyridine, triphenylphosphine or tetraethylammonium cyanide, the corresponding pyridium 109, phosphonium 111 and cyano hydrazones 113 were obtained, respectively (Scheme 21) .

Scheme 21: C(sp2)–H functionalization of benzaldehyde diphenyl hydrazone .

In 2020, Ruan and Sun et al. communicated the electrochemical dehydrogenative coupling between (hetero)aromatic or aliphatic aldehyde-derived hydrazones 114 and diarylphosphine oxide 115. The phosphorylation proceeded with slightly higher yield in the presence of a catalytic amount of manganese dibromide but its role was not clearly identified. Cyclic voltammetry analysis supported the initial oxidation of the hydrazone (Ep/2 of 4-methylbenzaldehyde-derived hydrazone = 0.89 V vs Ag/AgCl in CH3CN and Ep/2 of diphenylphosphine oxide > 0.89 V vs Ag/AgCl in CH3CN) (Scheme 22) . Similar yields were previously obtained for the same transformation using a substoichiometric amount of potassium persulfate as oxidant .

Scheme 22: Phosphorylation of aldehyde-derived hydrazones .

In 2022, the group of Huang employed aromatic azoles 118 as additional suitable nucleophilic partners for C(sp2)–H functionalization of aldehyde-derived N,N-disubstituted hydrazones 117. A wide range of aldehyde-derived hydrazones reacted smoothly with various azoles including pyrazole derivatives, imidazole, pyrazole and triazoles (Scheme 23) . Cyclic voltammetry studies confirmed that the azoles were redox inactive in the scan window while benzaldehyde-derived morpholino hydrazone could be readily oxidized at 1.18 V vs SCE in CH3CN supporting the route (a) of the general mechanism in Scheme 20.

Scheme 23: Azolation of aldehyde-derived hydrazones .

Initial SET oxidation of the partner

As mentioned above, if the partner is more readily oxidized than the hydrazone, then the general mechanism of the process is as described in Scheme 20, following route (b) for the first anodic oxidation. While investigating the electrochemical oxidative C(sp2)–H thiocyanation of ketene dithioacetals, Wang and Yang et al. mentioned one example of thiocyanation of benzaldehyde-derived hydrazone 120 using potassium thiocyanate as a source of thiocyanate radical. The electrolysis was conducted in the presence of two equivalents of water in acetonitrile with lithium perchlorate as electrolyte. It is interesting to notice that the isomerization of the product and subsequent ring closure discussed above (see Scheme 17) did not occur under these conditions (Scheme 24) .

Scheme 24: Thiocyanation of benzaldehyde-derived hydrazone 122 .

In 2023, Hajra et al. provided an electrochemical method for the C(sp2)–H sulfonylation of aromatic aldehyde-derived N,N-dialkylhydrazones 123 under constant current with two carbon electrodes. Aromatic and aliphatic sodium sulfinates 124 were employed as sources of sulfinate radicals under electrolyte-free reaction conditions. The targeted product was obtained in high yield regardless of the electronic properties of the substituents on the aromatic ring of either the hydrazone or the sulfinate salt (Scheme 25) . In parallel, a similar transformation was developed by Guo and Yang et al. Using two platinum electrodes and n-Bu4NBF4 as supporting electrolyte in a 1:1 mixture of acetonitrile/water, heteroromatic aldehyde-derived hydrazones as well as heteroaromatic sodium sulfinate salts were additional compatible reagents .

Scheme 25: Sulfonylation of aromatic aldehyde-derived hydrazones .

In 2022, Xie et al. achieved the electrochemical C(sp2)–H trifluoromethylation of (hetero)aromatic aldehyde-derived hydrazones. The galvanostatic electrolysis was performed with two carbone graphite electrodes. The Togni reagent 127 was chosen as a source of trifluoromethyl radical with redox neutral and electron-rich hydrazones through a paired electrolysis. In contrast, the Langlois reagent 128 was preferred for electron-poor substrates through an electrooxidative process (Scheme 26) .

Scheme 26: Trifluoromethylation of aromatic aldehyde-derived hydrazones .

Electrochemical access to diazo compounds

Diazo compounds are highly useful synthetic reagents in organic chemistry. For instance, they are regularly utilized as 1,3-dipoles in cycloaddition reactions or as precursor of carbenes under thermal, photochemical, and catalytic transition-metal-based transformations. However, their use is significantly hampered by their inherent instability and hazardous nature. Therefore, it is endlessly highly demanding to find a new mode of generation of diazo compounds from stable and safe precursors. The third part of this review is dedicated to electrochemical synthesis of diazo compounds from hydrazones. Transformations involving diazo compounds as either products or intermediates are covered.

While investigating the electrochemical oxidation of benzophenone hydrazones 130, Chiba et al. discovered that several products were obtained depending on the reaction conditions. For instance, the use of lithium perchlorate as supporting electrolyte in acetonitrile at room temperature in a divided cell equipped with two platinum electrodes led exclusively to diazines 131 in good yields. In contrast, when the electrolysis was conducted in methanol containing sodium methoxide in an undivided cell, three main products (namely benzophenone dimethyl acetals 133, diphenylmethyl methyl ethers 134 and diphenylmethanes 135) were obtained, the ratio of which was influenced by the electrode materials, the temperature and the amount of sodium methoxide. The range of isolated yields of the major products obtained under the appropriate reaction conditions is shown in Scheme 27. Based on control experiments, the authors proposed that 133–135 came from diazo intermediates 132, which could not be isolated .

Scheme 27: Electrooxidation of benzophenone hydrazones .

Building on this study and considering the high ability of diazo compounds to react with alkenes, Chiba et al. developed the electrochemical construction of diphenylcyclopropanes 137 from benzophenone hydrazones 130 and methacrylic acid derivatives 136. The transformation was conducted on a large scale (60 mmol) in an undivided cell using graphite anode and platinum cathode materials at 55 °C with a minimal amount of sodium methoxide, thereby limiting side products formation such as 133–135 or some oligomers of ethylenes (Scheme 28) .

Scheme 28:

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