Nitro compounds are important intermediates in medicine, agrochemicals, dyes and polymers. In recent years, the use of tert-butyl nitrite (t-BuONO) has attracted great attention and made promising progress. Currently, there is no review that specifically discusses the use of t-BuONO for the synthesis of nitro compounds via a C-H bond radical strategy. Therefore, this review aims to focus on the recent progress of using t-BuONO as a nitration reagent according to the type of reaction substrate, especially to focus on the discussion of reaction mechanism in representative cascade reactions to provide insights for the development prospects of tert-butyl nitrite.

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