Development of a bisphenol A based chemosensor for Al3+ and its application in cell imaging as well as in plant root imaging

Bisphenol A is a fluorophoric platform that is used to develop chemosensors for various species. Here we report one bisphenol A based Schiff-base molecule, 4,4'-(propane-2,2-diyl)bis(2-((E)-((2-hydroxy-5-methylphenyl)imino)methyl)phenol (Me-H4L), as a selective chemosensor for Al3+. Among several metal ions, its shows significant increment in its fluorescence intensity (50 fold) at 535 nm in the presence of Al3+ ions. Enhanced fluorescence has been attributed to CHEFF mechanism and inhibition of C=N isomerization. Limit of detection value of Me-H4L for Al3+ has been determined as 9.65 µM. Its quantum yield and lifetime increase considerably in the presence of the cation. Some theoretical calculations have been performed to explain the interaction between Al3+ and the probe. It has been applied in cell imaging studies using animal cells and plant root.

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