Wang JG, Zhang W, Li Y, Liu L. Hypertension in China: epidemiology and treatment initiatives. Nat Rev Cardiol. 2023;20:531–45.

Article  PubMed  Google Scholar 

Ye C, Zheng F, Wu N, Zhu GQ, Li XZ. Extracellular vesicles in vascular remodeling. Acta Pharmacol Sin. 2022;43:2191–201.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brown IAM, Diederich L, Good ME, DeLalio LJ, Murphy SA, Cortese-Krott MM, et al. Vascular smooth muscle remodeling in conductive and resistance arteries in hypertension. Arterioscler Thromb Vasc Biol. 2018;38:1969–85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Krzemińska J, Wronka M, Młynarska E, Franczyk B, Rysz J. Arterial hypertension-oxidative stress and inflammation. Antioxidants (Basel). 2022;11:172.

Article  PubMed  Google Scholar 

Lauder L, Azizi M, Kirtane AJ, Böhm M, Mahfoud F. Device-based therapies for arterial hypertension. Nat Rev Cardiol. 2020;17:614–28.

Article  PubMed  Google Scholar 

Wu LL, Zhang Y, Li XZ, Du XL, Gao Y, Wang JX, et al. Impact of selective renal afferent denervation on oxidative stress and vascular remodeling in spontaneously hypertensive rats. Antioxidants (Basel). 2022;11:1003.

Article  CAS  PubMed  Google Scholar 

Kim HW, Shi H, Winkler MA, Lee R, Weintraub NL. Perivascular adipose tissue and vascular perturbation/atherosclerosis. Arterioscler Thromb Vasc Biol. 2020;40:2569–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng CK, Ding H, Jiang M, Yin H, Gollasch M, Huang Y. Perivascular adipose tissue: Fine-tuner of vascular redox status and inflammation. Redox Biol. 2023;62:102683.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu H, Garcia-Barrio M, Jiang ZS, Chen YE, Chang L. Roles of perivascular adipose tissue in hypertension and atherosclerosis. Antioxid Redox Signal. 2021;34:736–49.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahmed A, Bibi A, Valoti M, Fusi F. Perivascular adipose tissue and vascular smooth muscle tone: friends or foes? Cells. 2023;12:1196.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bartelt A, Heeren J. Adipose tissue browning and metabolic health. Nat Rev Endocrinol. 2014;10:24–36.

Article  CAS  PubMed  Google Scholar 

Pilkington AC, Paz HA, Wankhade UD. Beige adipose tissue identification and marker specificity-overview. Front Endocrinol (Lausanne). 2021;12:599134.

Article  PubMed  Google Scholar 

Adachi Y, Ueda K, Nomura S, Ito K, Katoh M, Katagiri M, et al. Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling. Nat Commun. 2022;13:5117.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Padilla J, Jenkins NT, Vieira-Potter VJ, Laughlin MH. Divergent phenotype of rat thoracic and abdominal perivascular adipose tissues. Am J Physiol Regul Integr Comp Physiol. 2013;304:R543–52.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Takaoka M, Nagata D, Kihara S, Shimomura I, Kimura Y, Tabata Y, et al. Periadventitial adipose tissue plays a critical role in vascular remodeling. Circ Res. 2009;105:906–11.

Article  CAS  PubMed  Google Scholar 

Li Z, Li Q, Wang L, Li C, Xu M, Duan Y, et al. Targeting mitochondria-inflammation circle by renal denervation reduces atheroprone endothelial phenotypes and atherosclerosis. Redox Biol. 2021;47:102156.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang M, Han WZ, Zhang M, Fang WY, Zhai XR, Guan SF, et al. Chemical renal artery denervation with appropriate phenol in spontaneously hypertensive rats. J Geriatr Cardiol. 2018;15:695–702.

CAS  PubMed  PubMed Central  Google Scholar 

Eriguchi M, Tsuruya K. Renal sympathetic denervation in rats. Methods Mol Biol. 2016;1397:45–52.

Article  CAS  PubMed  Google Scholar 

Barp CG, Benedet PO, Assreuy J. Perivascular adipose tissue phenotype and sepsis vascular dysfunction: Differential contribution of NO, ROS and beta 3-adrenergic receptor. Life Sci. 2020;254:117819.

Article  CAS  PubMed  Google Scholar 

Zhang Z, Zhao L, Zhou X, Meng X, Zhou X. Role of inflammation, immunity, and oxidative stress in hypertension: New insights and potential therapeutic targets. Front Immunol. 2022;13:1098725.

Article  CAS  PubMed  Google Scholar 

Ma J, Li Y, Yang X, Liu K, Zhang X, Zuo X, et al. Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions. Signal Transduct Target Ther. 2023;8:168.

Article  PubMed  PubMed Central  Google Scholar 

Humphrey JD. Mechanisms of vascular remodeling in hypertension. Am J Hypertens. 2021;34:432–41.

Article  PubMed  Google Scholar 

Senoner T, Dichtl W. Oxidative stress in cardiovascular diseases: still a therapeutic target? Nutrients. 2019;11:2090.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chang L, Garcia-Barrio MT, Chen YE. Perivascular adipose tissue regulates vascular function by targeting vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2020;40:1094–109.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pan XX, Ruan CC, Liu XY, Kong LR, Ma Y, Wu QH, et al. Perivascular adipose tissue-derived stromal cells contribute to vascular remodeling during aging. Aging Cell. 2019;18:e12969.

Article  PubMed  PubMed Central  Google Scholar 

Gu W, Nowak WN, Xie Y, Le Bras A, Hu Y, Deng J, et al. Single-Cell RNA-sequencing and metabolomics analyses reveal the contribution of perivascular adipose tissue stem cells to vascular remodeling. Arterioscler Thromb Vasc Biol. 2019;39:2049–66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nour-Eldine W, Ghantous CM, Zibara K, Dib L, Issaa H, Itani HA, et al. Adiponectin attenuates angiotensin II-induced vascular smooth muscle cell remodeling through nitric oxide and the RhoA/ROCK pathway. Front Pharmacol. 2016;7:86.

Article  PubMed  PubMed Central  Google Scholar 

Guo R, Han M, Song J, Liu J, Sun Y. Adiponectin and its receptors are involved in hypertensive vascular injury. Mol Med Rep. 2018;17:209–15.

CAS  PubMed  Google Scholar 

Sowka A, Dobrzyn P. Role of perivascular adipose tissue-derived adiponectin in vascular homeostasis. Cells. 2021;10:1485.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eikelis N, Hering D, Marusic P, Duval J, Hammond LJ, Walton AS, et al. The effect of renal denervation on plasma adipokine profile in patients with treatment resistant hypertension. Front Physiol. 2017;8:369.

Article  PubMed  PubMed Central