Abstract

Background Ischemic heart disease (IHD) has the highest mortality rate in the globe. This returns to the poor diagnostic and therapeutic strategies including the early prevention methods.

Aims To assess the changes in the single channel electrocardiography (SCECG) at rest and on exercise test in patients with vs without IHD confirmed by stress computed tomography myocardial perfusion (CTP) imaging with vasodilatation stress-test.

Objectives IHD frequently have preventable risk factors and causes that lead to the disease appearance. However, the lack of the proper diagnostic and prevention tools remains a global challenge in or era despite the current scientific advances.

Material and methods A single center observational study included 80 participants from Moscow. The participants aged ≥ 40 years and given a written consent to participate in the study. Both groups, G1=31 with vs G2=49 without post stress induced myocardial perfusion defect, passed cardiologist consultation, anthropometric measurements, blood pressure and pulse rate, echocardiography, cardio-ankle vascular index, performing bicycle ergometry, recording 3-minutes SCECG (using CARDO-QVARK) before and just after bicycle ergometry, and then performing CTP. The LASSO regression with nested cross-validation was used to find association between CARDO-QVARK parameters and the existence of the perfusion defect. Statistical processing carried out using the R programming language v4.2, Python v.3.10 [^R], and Statistica 12 programme.

Results The CARDO-QVARK parameters analysis have a specificity 75.5 % [95 % confidence interval (CI); 0.628; 0.88], sensitivity 51.6 % [95 % CI; 0.333; 0.695], area under the curve (AUC) 67 % [95 % CI; 0.530; 0.801] in compare to bicycle ergometry AUC; 50.7 % [95 % CI; 0.388; 0.625], specificity 53.1 % [95 % CI; 0.392; 0.673], sensitivity 48.4 % [95 % CI; 0.306; 0.657], based on our study results.

Conclusion The SCECG have no statistically significant higher diagnostic accuracy in compare to bicycle ergometry. However, CARDO-QVARK has the potential to improve the diagnostic accuracy of the bicycle ergometry.

Other Further investigations required to uncover the hidden capabilities of CARDO-QVARK in the diagnosis of ischemic heart disease.

Competing Interest Statement

The authors have declared no competing interest.

Clinical Trial

NCT06181799

Funding Statement

The work of Philipp Kopylov and Alexander Suvorov was financed by the government assignment 1023022600020-6 <Application of mass spectrometry and exhaled air emission spectrometry for cardiovascular risk stratification>. The work of Basheer Marzoog and Peter Chomakhidze was financed by the Ministry of Science and Higher Education of the Russian Federation within the framework of state support for the creation and development of World-Class Research Center <Digital biodesign and personalized healthcare> № 075-15-2022-304.

Author Declarations

I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Yes

The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

The study approved by the ethical commitment of the Sechenov University, Russia, from “Ethics Committee Requirement № 19-23 from 26.10.2023”

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Yes

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Data Availability

All data produced in the present work are contained in the manuscript

List of abbreviationsCVDcardiovascular diseaseCTPstress computed tomography myocardial perfusion imaging