Valori, C. F., Possenti, A., Brambilla, L. & Rossi, D. Challenges and opportunities of targeting astrocytes to halt neurodegenerative disorders. Cells 10, 2019 (2021).
Article CAS PubMed PubMed Central Google Scholar
Prabakaran, A. et al. Nose-to-brain drug delivery for the treatment of Alzheimer’s disease: current advancements and challenges. Expert Opin. Drug Deliv. 19, 87–102 (2022).
Markowicz-Piasecka, M. et al. Current approaches to facilitate improved drug delivery to the central nervous system. Eur. J. Pharm. Biopharm. 181, 249–262 (2022).
Article CAS PubMed Google Scholar
Doody, R. S. et al. A phase 3 trial of semagacestat for treatment of Alzheimer’s disease. N. Engl. J. Med. 369, 341–350 (2013).
Article CAS PubMed Google Scholar
Imbimbo, B. P. & Giardina, G. A. M. γ-Secretase inhibitors and modulators for the treatment of Alzheimer’s disease: disappointments and hopes. Curr. Top. Med. Chem. 11, 1555–1570 (2011).
Article CAS PubMed Google Scholar
Kouhi, A. et al. Brain disposition of antibody-based therapeutics: dogma, approaches and perspectives. Int. J. Mol. Sci. 22, 6442 (2021).
Article CAS PubMed PubMed Central Google Scholar
Chang, H.-Y. et al. Brain pharmacokinetics of anti-transferrin receptor antibody affinity variants in rats determined using microdialysis. mAbs 13, 1874121 (2021).
Article PubMed PubMed Central Google Scholar
Keiser, M. S. et al. Toxicity after AAV delivery of RNAi expression constructs into nonhuman primate brain. Nat. Med. 27, 1982–1989 (2021).
Article CAS PubMed PubMed Central Google Scholar
Ling, Q., Herstine, J. A., Bradbury, A. & Gray, S. J. AAV-based in vivo gene therapy for neurological disorders. Nat. Rev. Drug Discov. 22, 789–806 (2023).
Article CAS PubMed Google Scholar
Lee, H. et al. Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALS. Nat. Neurosci. 24, 1673–1685 (2021).
Article CAS PubMed PubMed Central Google Scholar
Herb, B. R. et al. Single-cell genomics reveals region-specific developmental trajectories underlying neuronal diversity in the human hypothalamus. Sci. Adv. 9, eadf6251 (2023).
Article CAS PubMed PubMed Central Google Scholar
Vialle, R. A., de Paiva Lopes, K., Bennett, D. A., Crary, J. F. & Raj, T. Integrating whole-genome sequencing with multi-omic data reveals the impact of structural variants on gene regulation in the human brain. Nat. Neurosci. 25, 504–514 (2022).
Article CAS PubMed PubMed Central Google Scholar
Yao, Z. et al. A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain. Nature 624, 317–332 (2023). This article introduces a collaborative effort from the BRAIN Initiative Cell Census Network, presenting cellular maps of the mouse brain with high spatial resolution.
Article CAS PubMed PubMed Central Google Scholar
Chini, M. & Hanganu-Opatz, I. L. Prefrontal cortex development in health and disease: lessons from rodents and humans. Trends Neurosci. 44, 227–240 (2021).
Article CAS PubMed Google Scholar
Fu, H., Hardy, J. & Duff, K. E. Selective vulnerability in neurodegenerative diseases. Nat. Neurosci. 21, 1350–1358 (2018). This paper provides a comprehensive overview of the current understanding of biological mechanisms underpinning selective neuronal and regional vulnerability in neurological disorders.
Article CAS PubMed PubMed Central Google Scholar
Goodkind, M. et al. Identification of a common neurobiological substrate for mental illness. JAMA Psychiatry 72, 305–315 (2015).
Article PubMed PubMed Central Google Scholar
Del Tredici, K., Rüb, U., De Vos, R. A. I., Bohl, J. R. E. & Braak, H. Where does Parkinson disease pathology begin in the brain? J. Neuropathol. Exp. Neurol. 61, 413–426 (2002).
De Marchi, F. et al. Cognitive dysfunction in amyotrophic lateral sclerosis: can we predict it? Neurol. Sci. 42, 2211–2222 (2021).
Article PubMed PubMed Central Google Scholar
Crockford, C. et al. ALS-specific cognitive and behavior changes associated with advancing disease stage in ALS. Neurology 91, e1370–e1380 (2018).
Article PubMed PubMed Central Google Scholar
Lassmann, H. Multiple sclerosis pathology. Cold Spring Harb. Perspect. Med. 8, a028936 (2018).
Article PubMed PubMed Central Google Scholar
Haider, L. et al. The topograpy of demyelination and neurodegeneration in the multiple sclerosis brain. Brain 139, 807–815 (2016).
Article PubMed PubMed Central Google Scholar
Knopman, D. S. et al. Alzheimer disease. Nat. Rev. Dis. Primers 7, 33 (2021).
Article PubMed PubMed Central Google Scholar
Schöll, M. et al. Biomarkers for tau pathology. Mol. Cell. Neurosci. 97, 18–33 (2019).
Article PubMed PubMed Central Google Scholar
Musolino, P. L. et al. Brain endothelial dysfunction in cerebral adrenoleukodystrophy. Brain 138, 3206–3220 (2015).
Article PubMed PubMed Central Google Scholar
Pong, S., Karmacharya, R., Sofman, M., Bishop, J. R. & Lizano, P. The role of brain microvascular endothelial cell and blood-brain barrier dysfunction in schizophrenia. Complex Psychiatry 6, 30–46 (2020).
Article CAS PubMed PubMed Central Google Scholar
Estudillo, E. et al. Thinking outside the black box: are the brain endothelial cells the new main target in Alzheimer’s disease? Neural Regen. Res. 18, 2592 (2023).
Article CAS PubMed PubMed Central Google Scholar
Yang, A. C. et al. A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk. Nature 603, 885–892 (2022).
Article CAS PubMed PubMed Central Google Scholar
Mrdjen, D. et al. The basis of cellular and regional vulnerability in Alzheimer’s disease. Acta Neuropathol. 138, 729–749 (2019).
Article PubMed PubMed Central Google Scholar
Bennett, H. C. & Kim, Y. Pericytes across the lifetime in the central nervous system. Front. Cell. Neurosci. 15, 627291 (2021).
Article CAS PubMed PubMed Central Google Scholar
Giguère, N., Burke Nanni, S. & Trudeau, L.-E. On cell loss and selective vulnerability of neuronal populations in Parkinson’s disease. Front. Neurol. 9, 455 (2018).
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