Borlaug BA. Evaluation and management of heart failure with preserved ejection fraction. Nat Rev Cardiol. 2020;17:559–73.

Article  CAS  PubMed  Google Scholar 

Okura Y, Ramadan MM, Ohno Y, et al. Impending epidemic: future projection of heart failure in Japan to the year 2055. Circ J. 2008;72:489–91.

Article  PubMed  Google Scholar 

Shiba N, Nochioka K, Miura M, et al. CHART-2 Investigators. trend of westernization of etiology and clinical characteristics of heart failure patients in Japan–first report from the CHART-2 study. Circ J. 2011;75:823–33.

Article  PubMed  Google Scholar 

Shiraishi Y, Kohsaka S, Sato N, et al. 9-year trend in the management of acute heart failure in Japan: a report from the national consortium of acute heart failure registries. J Am Heart Assoc. 2018;7: e008687.

Article  PubMed  PubMed Central  Google Scholar 

Huynh QL, Negishi K, De Pasquale CG, et al. Cognitive domains and postdischarge outcomes in hospitalized patients with heart failure. Circ Heart Fail. 2019;12: e006086.

Article  PubMed  Google Scholar 

Obokata M, Kane GC, Reddy YNV, et al. Role of diastolic stress testing in the evaluation for heart failure with preserved ejection fraction: a simultaneous invasive-echocardiographic study. Circulation. 2017;135:825–38.

Article  PubMed  Google Scholar 

Saito Y, Obokata M, Harada T, et al. Prognostic Benefit of Early Diagnosis with Exercise Stress Testing in Heart Failure with Preserved Ejection Fraction. Eur J Prev Cardiol. 2023;30:902–11.

Article  PubMed  Google Scholar 

Pop-Busui R, Januzzi JL, Bruemmer D, et al. Heart failure: an underappreciated complication of diabetes. a consensus report of the American Diabetes Association. Diabetes Care. 2022;45:1670–90.

Article  PubMed  PubMed Central  Google Scholar 

The Statement on Heart Failure Management Using Blood BNP and NT-proBNP Revised 2023 from the Japanese Heart Failure Society. https://www.asas.or.jp/jhfs/topics/bnp20231017.html

Harada T, Kagami K, Kato T, et al. Echocardiography in the diagnostic evaluation and phenotyping of heart failure with preserved ejection fraction. J Cardiol. 2022;79:679–90.

Article  PubMed  Google Scholar 

Harada T, Kagami K, Kato T, et al. Exercise stress echocardiography in the diagnostic evaluation of heart failure with preserved ejection fraction. J Cardiovasc Dev Dis. 2022;9:87.

PubMed  PubMed Central  Google Scholar 

Yuasa N, Obokata M, Harada T, et al. Characterization and prognostic importance of chronotropic incompetence in heart failure with preserved ejection fraction. J Cardiol. 2024;83:113–20.

Article  PubMed  Google Scholar 

Kagami K, Obokata M, Harada T, et al. Diastolic filling time, chronotropic response, and exercise capacity in heart failure and preserved ejection fraction with sinus rhythm. J Am Heart Assoc. 2022. https://doi.org/10.1161/JAHA.121.026009.

Article  PubMed  PubMed Central  Google Scholar 

Pieske B, Tschöpe C, De Boer RA, et al. How to diagnose heart failure with preserved ejection fraction: The HFA-PEFF diagnostic algorithm: A consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Eur Heart J. 2019;40:3297–317.

Article  PubMed  Google Scholar 

Kittleson MM, Panjrath GS, Amancherla K, et al. 2023 acc expert consensus decision pathway on management of heart failure with preserved ejection fraction: a report of the American college of cardiology solution set oversight committee. J Am Coll Cardiol. 2023;81:1835–78.

Article  PubMed  Google Scholar 

McDonagh TA, Metra M, Adamo M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021;42:3599–726.

Article  CAS  PubMed  Google Scholar 

Obokata M, Reddy YNV, Pislaru SV, et al. Evidence supporting the existence of a distinct obese phenotype of heart failure with preserved ejection fraction. Circulation. 2017;136:6–19.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Obokata M, Reddy YNV, Melenovsky V, et al. Uncoupling between intravascular and distending pressures leads to underestimation of circulatory congestion in obesity. Eur J Heart Fail. 2022;24:353–61.

Article  CAS  PubMed  Google Scholar 

Harada T, Obokata M. Obesity-related heart failure with preserved ejection fraction. Heart Fail Clin. 2020;16:357–68.

Article  PubMed  Google Scholar 

Reddy YNV, Rikhi A, Obokata M, et al. Quality of life in heart failure with preserved ejection fraction: importance of obesity, functional capacity, and physical inactivity. Eur J Heart Fail. 2020;22:1009–18.

Article  CAS  PubMed  Google Scholar 

Pabón MA, Cunningham JW, Claggett BL, et al. Natriuretic peptide-based inclusion criteria in heart failure with preserved ejection fraction clinical trials: insights from PARAGON-HF. Eur J Heart Fail. 2022;24:672–7.

Article  PubMed  Google Scholar 

Verbrugge FH, Omote K, Reddy YNV, et al. Heart failure with preserved ejection fraction in patients with normal natriuretic peptide levels is associated with increased morbidity and mortality. Eur Heart J. 2022;43:1941–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Obokata M, Reddy YNV. The role of echocardiography in heart failure with preserved ejection fraction: what do we want from imaging? Heart Fail Clin. 2019;15:241–56.

Article  PubMed  PubMed Central  Google Scholar 

Obokata M, Reddy YNV, Borlaug BA. Diastolic dysfunction and heart failure with preserved ejection fraction: understanding mechanisms by using noninvasive methods. JACC Cardiovasc Imaging. 2020;13:245–57.

Article  PubMed  Google Scholar 

Bozkurt B, Coats AJS, Tsutsui H, et al. Universal definition and classification of heart failure: a report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure: endorsed by the Canadian Heart Failure Society, Heart Failure Association of India, Cardiac Society of Australia and New Zealand, and Chinese Heart Failure Association. Eur J Heart Fail. 2021;23:352–80.

Article  PubMed  Google Scholar 

Nagueh SF, Smiseth OA, Appleton CP, et al. Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2016;29:277–314.

Article  PubMed  Google Scholar 

Sato K, Grant ADM, Negishi K, et al. Reliability of updated left ventricular diastolic function recommendations in predicting elevated left ventricular filling pressure and prognosis. Am Heart J. 2017;189:28–39.

Article  PubMed  Google Scholar 

Lancellotti P, Galderisi M, Edvardsen T, et al. Echo-Doppler estimation of left ventricular filling pressure: results of themulticentre EACVI Euro-Filling study. Eur Heart J Cardiovasc Imaging. 2017;18:961–8.

Article  PubMed  Google Scholar 

Obokata M, Olson TP, Reddy YNV, et al. Haemodynamics, dyspnoea, and pulmonary reserve in heart failure with preserved ejection fraction. Eur Heart J. 2018;39:2810–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Harada T, Obokata M, Kagami K, et al. Utility of E/e’ ratio during low-level exercise to diagnose heart failure with preserved ejection fraction. JACC Cardiovasc Imaging. 2022. https://doi.org/10.1016/j.jcmg.2022.10.024.

Article  PubMed  Google Scholar 

Reddy YNV, Carter RE, Obokata M, et al. A simple, evidence-based approach to help guide diagnosis of heart failure with preserved ejection fraction. Circulation. 2018;138:861–70.

Article  PubMed  PubMed Central  Google Scholar 

Reddy YNV, Kaye DM, Handoko ML, et al. Diagnosis of heart failure with preserved ejection fraction among patients with unexplained dyspnea. JAMA Cardiol. 2022;7:891–9.

Article  PubMed  PubMed Central  Google Scholar 

Obokata M, Sorimachi H, Harada T, et al. Epidemiology, pathophysiology, diagnosis, and therapy of heart failure with preserved ejection fraction in Japan. J Card Fail. 2023;29:375–88.