Depression represents a significant and prevalent challenge among individuals with multiple sclerosis (MS) substantially impacting their quality of life (QoL). This study explores the mediating role of psychological resilience in the relationship between depression and QoL in a sample of patients with multiple sclerosis (PwMS). This online cross-sectional study involves 179 Relapsing-Remitting Multiple Sclerosis (RRMS) patients. The PwMS completed three questionnaires: the Chicago Multiscale Depression Inventory, the Connor-Davidson Resilience Scale, and the Multiple Sclerosis Quality of Life (MSQOL-29). The results confirmed that higher levels of depression were associated with lower QoL in RRMS patients. However, the inclusion of psychological resilience as a mediator attenuated this direct effect, suggesting that resilience plays a crucial role in mitigating the negative impact of depression on QoL.

The authors have declared no competing interest.

This study did not receive any funding

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The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

The project was approved by the ethics committee of the Department of Psychology of the Universidad Central "Marta Abreu" de Las Villas.

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Yes

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Data available on request from the authors