High Throughput Screening in Drug Discovery: Problems and Solutions

Jones, M. and Goodyear, R.L., ACS Med. Chem. Lett., 2023, vol. 14, p. 916. https://doi.org/10.1021/acsmedchemlett.3c00073

Article  CAS  PubMed  Google Scholar 

Bon, M., Bilsland, A., Bower, J., and McAulay, K., Mol. Oncol., 2022, vol. 16, p. 3761. https://doi.org/10.1002/1878-0261.13277

Article  CAS  PubMed  PubMed Central  Google Scholar 

Blay, V., Tolani, B., Ho, S.P., and Arkin, M.R., Drug Discovery Today, 2020, vol. 25, p. 1807. https://doi.org/10.1016/j.drudis.2020.07.024

Article  CAS  PubMed  Google Scholar 

Thirstrup, K., Christensen, S., Moller, H.A., Ritzen, A., Bergstrom, A.L., Sager, T.N., and Jensen, H.S., Pharmacol. Res., 2011, vol. 64, p. 268. https://doi.org/10.1016/j.phrs.2011.03.017

Article  CAS  PubMed  Google Scholar 

Moi, P., Chan, K., Asunis, I., Cao, A., and Kan, Y.W., Proc. Natl. Acad. Sci. U. S. A., 1994, vol. 91, p. 9926. https://doi.org/10.1073/pnas.91.21.9926

Article  CAS  PubMed  PubMed Central  Google Scholar 

Crunkhorn, S., Nat. Rev. Drug Discovery, 2012, vol. 11, p. 96. https://doi.org/10.1038/nrd3655

Article  CAS  PubMed  Google Scholar 

Gan, L. and Johnson, J.A., Biochim. Biophys. Acta, Mol. Basis Dis., 2014, vol. 1842, p. 1208. https://doi.org/10.1016/j.bbadis.2013.12.011

Article  CAS  Google Scholar 

Joshi, G. and Johnson, J.A., Recent Pat. CNS Drug Discovery, 2012, vol. 7, p. 218. https://doi.org/10.2174/157488912803252023

Article  CAS  PubMed  Google Scholar 

Ramsey, C.P., Glass, C.A., Montgomery, M.B., Lindl, K.A., Ritson, G.P., Chia, L.A., Hamilton, R.L., Chu, C.T., and Jordan-Sciutto, K.L., J. Neuropathol. Exp. Neurol., 2007, vol. 66, p. 75. https://doi.org/10.1097/nen.0b013e31802d6da9

Article  CAS  PubMed  Google Scholar 

Tapias, V., Jainuddin, S., Ahuja, M., Stack, C., Elipenahli, C., Vignisse, J., Gerges, M., Starkova, N., Xu, H., Starkov, A.A., Bettendorff, L., Hushpulian, D.M., Smirnova, N.A., Gazaryan, I.G., Kaidery, N.A., Wakade, S., Calingasan, N.Y., Thomas, B., Gibson, G.E., Dumont, M., and Beal, M.F., Hum. Mol. Genet., 2018, vol. 27, p. 2874. https://doi.org/10.1093/hmg/ddy201

Article  CAS  PubMed  PubMed Central  Google Scholar 

Smirnova, N.A., Kaidery, N.A., Hushpulian, D.M., Rakhman, I.I., Poloznikov, A.A., Tishkov, V.I., Karuppagounder, S.S., Gaisina, I.N., Pekcec, A., Van Leyen, K., Kazakov, S.V., Yang, L., Thomas, B., Ratan, R.R., and Gazaryan, I.G., Aging Dis., 2016, vol. 7, p. 745. https://doi.org/10.14336/AD.2016.0505

Article  PubMed  PubMed Central  Google Scholar 

Ahuja, M., Kaidery, N.A., Yang, L., Calingasan, N., Smirnova, N., Gaisin, A., Gaisina, I.N., Gazaryan, I., Hushpulian, D.M., Kaddour-Djebbar, I., Bollag, W.B., Morgan, J.C., Ratan, R.R., Starkov, A.A., Beal, M., and Thomas, B., J. Neurosci., 2016, vol. 36, p. 6332. https://doi.org/10.1523/JNEUROSCI.0426-16.2016

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kaidery, N.A., Banerjee, R., Yang, L., Smirnova, N.A., Hushpulian, D.M., Liby, K.T., Williams, C.R., Yamamoto, M., Kensler, T.W., Ratan, R.R., Sporn, M.B., Beal, M.F., Gazaryan, I.G., and Thomas, B., Antioxid. Redox Signaling, 2013, vol. 18, p. 139. https://doi.org/10.1089/ars.2011.4491

Article  CAS  Google Scholar 

Wu, K.C., McDonald, P.R., Liu, J.J., Chaguturu, R., and Klaassen, C.D., PLoS One, 2012, vol. 7, p. e44686. https://doi.org/10.1371/journal.pone.0044686

Article  CAS  PubMed  PubMed Central  Google Scholar 

Smirnova, N.A., Rakhman, I., Moroz, N., Basso, M., Payappilly, J., Kazakov, S., Hernandez-Guzman, F., Gaisina, I.N., Kozikowski, A.P., Ratan, R.R., and Gazaryan, I.G., Chem. Biol., 2010, vol. 17, p. 380. https://doi.org/10.1016/j.chembiol.2010.03.008

Article  CAS  PubMed  PubMed Central  Google Scholar 

Smirnova, N.A., Haskew-Layton, R.E., Basso, M., Hushpulian, D.M., Payappilly, J.B., Speer, R.E., Ahn, Y.H., Rakhman, I., Cole, P.A., Pinto, J.T., Ratan, R.R., and Gazaryan, I.G., Chem. Biol., 2011, vol. 18, p. 752. https://doi.org/10.1016/j.chembiol.2011.03.013

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khristichenko, Y., Hushpulian, D.M., Smirnova, N.A., Zakhariants, A.A., Chubar, T.A., Tishkov, V.I., Gazaryan, I.G., and Poloznikov, A.A., Moscow Univ. Chem. Bull., 2020, vol. 75, p. 172. https://doi.org/10.3103/S0027131420030062

Article  Google Scholar 

Baell, J.B. and Holloway, G.A., J. Med. Chem., 2010, vol. 53, p. 2719. https://doi.org/10.1021/jm901137j

Article  CAS  PubMed  Google Scholar 

Fox, R.J., Miller, D.H., Phillips, J.T., Hutchinson, M., Havrdova, E., Kita, M., Yang, M., Raghupathi, K., Novas, M., Sweetser, M.T., Viglietta, V., and Dawson, K.T., CONFIRM Study Investigators, N. Engl. J. Med., 2012, vol. 367, p. 1087. https://doi.org/10.1056/NEJMoa1206328

Article  CAS  PubMed  Google Scholar 

Sweetser, M.T., Dawson, K.T., and Bozic, C., N. Engl. J. Med., 2013, vol. 368, p. 1659. https://doi.org/10.1056/NEJMc1300283

Article  CAS  PubMed  Google Scholar 

de Zeeuw, D., Akizawa, T., Agarwal, R., Audhya, P., Bakris, G.L., Chin, M., Krauth, M., Lambers Heerspink, H.J., Meyer, C.J., McMurray, J.J., Parving, H.-H., Pergola, P.E., Remuzzi, G., Toto, R.D., Vaziri, N.D., Wanner, C., Warnock, D.G., Wittes, J., and Chertow, G.M., Am. J. Nephrol., 2013, vol. 37, p. 212. https://doi.org/10.1159/000346948

Article  CAS  PubMed  Google Scholar 

Lee, A., Drugs, 2023, vol. 83, p. 725. https://doi.org/10.1007/s40265-023-01874-9.23

Article  CAS  PubMed  Google Scholar 

Rowlands, H., Tschapalda, K., Blackett, C., Ivanov, D., Plant, D., Shaw, J., Thomas, A., Packer, M., Arnold, L., and Holdgate, G.A., SLAS Discovery, 2023, vol. 28, p. 102. https://doi.org/10.1016/j.slasd.2023.01.006

Article  CAS  PubMed  Google Scholar 

Vachal, P., Miao, S., Pierce, J.M., Guiadeen, D., Colandrea, V.J., Wyvratt, M.J., Salowe, S.P., Sonatore, L.M., Milligan, J.A., Hajdu, R., Gollapudi, A., Keohane, C.A., Lingham, R.B., Mandala, S.M., DeMartino, J.A., Tong, X., Wolff, M., Steinhuebel, D., Kieczykowski, G.R., Fleitz, F.J., Chapman, K., Athanasopoulos, J., Adam, G., Akyuz, C.D., Jena, D.K., Lusen, J.W., Meng, J., Stein, B.D., Xia, L., Sherer, E.C., and Hale, J.J., J. Med. Chem., 2012, vol. 55, p. 2945. https://doi.org/10.1021/jm201542d

Article  CAS  PubMed  Google Scholar 

Lipinski, C.A., J. Pharmacol. Toxicol. Methods, 2000, vol. 44, p. 235. https://doi.org/10.1016/s1056-8719(00)00107-6

Article  CAS  PubMed  Google Scholar 

Marcotte, D., Zeng, W., Hus, J.-C., McKenzie, A., Hession, C., Jin, P., Bergeron, C., Lugovskoy, A., Enyedy, I., Cuervo, H., Wang, D., Atmanene, C., Roecklin, D., Vecchi, M., Vivat, V., Kraemer, J., Winkler, D., Hong, V., Chao, J., Lukashev, M., and Silvian, L., Bioorg. Med. Chem., 2013, vol. 21, p. 4011. https://doi.org/10.1016/j.bmc.2013.04.019

Article  CAS  PubMed  Google Scholar 

Zhuang, C., Narayanapillai, S., Zhang, W., Sham, Y.Y., and Xing, C., J. Med. Chem., 2014, vol. 57, p. 1121. https://doi.org/10.1021/jm4017174

Article  CAS  PubMed  Google Scholar 

Hu, L., Magesh, S., Chen, L., Wang, L., Lewis, T.A., Chen, Y., Khodier, C., Inoyama, D., Beamer, L.J., Emge, T.J., Shen, J., Kerrigan, J.E., Kong, A.-N.T., Dandapani, S., Palmer, M., Schreiber, S.L., and Munoz, B., Bioorg. Med. Chem. Lett., 2013, vol. 23, p. 3039. https://doi.org/10.1016/j.bmcl.2013.03.013

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhuang, C., Wu, Z., Xing, C., and Miao, Z., MedChemComm, 2017, vol. 8, p. 286. https://doi.org/10.1039/c6md00500d

Article  CAS  PubMed  Google Scholar 

O’Reilly, L.P., Luke, C.J., Perlmutter, D.H., Silverman, G.A., and Pak, S.C., Adv. Drug Delivery Rev., 2014, vol. 69, p. 247. https://doi.org/10.1016/j.addr.2013.12.001

Article  CAS  Google Scholar 

Pandey, U.B. and Nichols, C.D., Pharmacol. Rev., 2011, vol. 63, p. 411. https://doi.org/10.1124/pr.110.003293

Article  CAS  PubMed  PubMed Central  Google Scholar 

Delvecchio, C., Tiefenbach, J., and Krause, H.M., Assay Drug Dev. Technol., 2011, vol. 9, p. 354. https://doi.org/10.1089/adt.2010.0346

Article  CAS  PubMed  Google Scholar 

Giacomotto, J. and Segalat, L., Br. J. Pharmacol., 2010, vol. 160, p. 204. https://doi.org/10.1111/j.1476-5381.2010.00725.x

Article  CAS 

留言 (0)

沒有登入
gif