Authors Evangelos G. Baltagiannis, Athina Tsili, Anna Goussia, Anastasia Glantzouni, Konstantinos Frigkas, Antonia Charchanti, Georgios K. Glantzounis, Ilias P. Gomatos.

Cystic liver disease has been increasingly reported in the literature, with a prevalence as high as 15-18%. Hepatic cysts are usually discovered incidentally, while their characterization and classification rely on improved imaging modalities. Complex cystic liver lesions comprise a wide variety of novel, re-introduced, and re-classified clinical entities. This spectrum of disorders ranges from non-neoplastic conditions to benign and malignant tumors. Their
clinicopathological features, prognostic factors, and oncogenic pathways are incompletely understood. Despite representing a heterogeneous group of disorders, they can have similar clinical and imaging characteristics. As a result, the diagnosis and management of complex liver cysts can become quite challenging. Furthermore, inappropriate diagnosis and management can lead to high morbidity and mortality. In this review, we aim to offer up-to-date insight into the diagnosis, classification, and management of the most common complex cystic liver
lesions.

Keywords Complex cystic liver lesion, hepatic mucinous cystic neoplasm, intraductal papillary neoplasm, infectious cyst, hydatid liver disease

Ann Gastroenterol 2024; 37 (3): 255-265