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metadata.dc.identifier.doi: https://doi.org/10.56042/ijeb.v62i06.3751Title: Alpha-Tocopherol ameliorates arsenic induced nephrotoxicity in Wistar ratsAuthors: Mathur, Astha
Kumar, Navneet
Bunker, Suresh Kumar
John, Placheril JosephKeywords: DNA damage;Heavy metal contamination;Kidney;Oxidative stress;Soil pollution;Water pollution;Vitamin EIssue Date: Jun-2024Publisher: NIScPR-CSIR,IndiaAbstract: α-Tocopherol’s (Vitamin E) antioxidant and anti-inflammatory properties may help reduce the progression of fibrosis in kidney by limiting tissue damage and inflammation induced by arsenic. Knowledge of the mechanisms of action of natural medicinal substances in arsenic toxicity will be improved by the analysis of the ameliorative effects of α-tocopherol. The goal of the current investigation was to determine whether Vitamin E can protect rats from nephrotoxicity caused by sodium arsenite (NaAsO2). Twenty-five Wistar rats were split into five groups viz: Group I with distilled water as control; Group II-IV with 8.4 (Low dose)/12.3 (Moderate dose)/16.4 mg/kg NaAsO2 (High dose); and Group V as in Gr. IV + 50 mg/kg ɑ-Tocopherol. Both the doses were administered orally to rats for 60 days. α-tocopherol decreased the concentration of serum parameters like urea nitrogen (UN) and creatinine (CRT) whereas increased the concentration of albumin (ALB), acid phosphatase (ACP), alkaline phosphatase (ALP) and succinic dehydrogenase (SDH) (P Page(s): 400-409ISSN: 0975-1009 (Online); 0019-5189 (Print)Appears in Collections:IJEB Vol.62(06) [June 2024]

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