Background: Heart failure with preserved ejection fraction (HFpEF) has a high hospitalization rate. While recent guidelines recommend specific parameters like E/e’, e’ velocity, and left atrial volume index (LAVI) for diagnosing HFpEF, their clinical accuracy remains limited. Left atrial (LA) strain has emerged as a potential diagnostic parameter, yet its role in the Vietnamese population is unclear. This study aims to evaluate LA strain’s diagnostic role in HFpEF among Vietnamese patients, exploring its relationship with established parameters of left ventricle (LV) diastolic function to determine its potential utility as a diagnostic tool. Methods: A cross-sectional study was conducted from 15/04/2022 to 01/12/2023, involving 118 subjects, including 49 patients with HFpEF and 69 individuals without cardiac dysfunction. The study subjects were evaluated for LA strain and HFA-PEFF. Results: LA strain including LA reservoir (LASr), conduit (LAScd), and contractile (LASct) function, in the HFpEF group were 19.97% ± 9.18%, 9.08% ± 6.18%, and 10.89% ± 5.16%, respectively. The control group had corresponding LASr, LAScd, and LASct values of 34.70% ± 5.38%, 17.33% ± 5.72%, and 17.38% ± 4.41% (p < 0.001). The area under the curve (AUC) for LASr, LAScd, LAScr, HFA-PEFF, LAVI, and GLS to diagnose HFpEF was 0.877, 0.836, 0.749, 0.975, 0.587, and 0.717, respectively. Comparing the AUCs for diagnosing HFpEF between LASr and HFA-PEFF, no difference was found with p = 0.062. Conclusion: LA strain has a diagnostic value equivalent to the HFA-PEFF score in diagnosing HFpEF. These indices could be incorporated into the existing guidelines to enhance the diagnosis of HFpEF.

The authors have declared no competing interest.

The author(s) received no specific funding for this work.

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The research described received approval from the Institutional Review Board (IRB) or oversight body, specifically, The Institutional Ethics Committee of Hue University of Medicine and Pharmacy. The approval number for this study is H2022/034. Professor Vo Tam serves as the Chairman of the committee, while Associate Professor Nguyen Thanh Thao holds the position of Secretary.

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