Databases with mental and behavioral health surveys suffer from missingness when participants skip the entire survey, affecting the data quality and sample size. We investigated the missing data patterns and evaluate the imputation performance in Simons Powering Autism Research (SPARK), a large-scale autism cohort consists of over 117,000 participants. Four common methods were assessed: Multiple Imputation by Chained Equations (MICE), K-Nearest Neighbors (KNN), MissForest, and Multiple Imputation with Denoising Autoencoders (MIDAS). In a complete subset of 15,196 autism participants, we simulated three types of missingness patterns. We observed that MIDAS and KNN performed the best as the rate of random missingness increased and when blockwise missingness was simulated. The average computational times for MIDAS and KNN were 10 minutes, 35 minutes for MissForest, and 290 minutes for MICE. MIDAS and KNN both provide promising imputation performance in mental and behavioral health survey data that exhibit blockwise missingness patterns.

The authors have declared no competing interest.

This study did not receive any funding

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SFARI Base (https://base.sfari.org)

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SPARK Phenotype Dataset is accessible through application at SFARI Base.

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