Design of the randomized controlled trial(RCT) studies that have been published on the outcomes of hypertonic dextrose proliferation treatment in individuals with rotator cuff lesions. Nevertheless, animal experimentation was excluded. Prolotherapy, hypertonic dextrose, & rotator cuff are the search terms. The time frame for the search was from the opening of the library through February 2023. There are total 191 literatures in the study, including PubMed (n = 40),Embase(n = 69),Cochrane Library(n = 28), Web of Science (n = 54). Records after duplicates removed (n = 102), abstracts screened (n = 18) ,records excluded(n = 7). There are total 6 studies included in quantitative synthesis.

Patients who meet the diagnostic criteria for Rotator Cuff Lesions patients, have poor oral drug efficacy, and a strong willingness to receive injection therapy. Among them, patients with non traumatic and refractory rotator cuff diseases such as chronic rotator cuff injury, long head tendon disease of the biceps brachii, partial tears, and full thickness tears, and calcific tendonitis are all included in the list of rotator cuff disease patients.

(1) Joint infection (including local skin infection), joint tumor or tuberculosis in the affected joint; (2) Abnormal coagulation function; (3) Existence of severe cardiovascular diseases and severe liver and kidney dysfunction; (4) Combining cognitive and mental disorders, unable to cooperate with treatment and follow-up.

Individuals with rotator cuff lesions in the intervention group were treated with hypertonic dextrose proliferation therapy, whereas individuals in the control condition were treated with a placebo. The placebo treatment mainly uses 5% physiological saline, and the control group’s treatment also includes conventional treatment methods such as physical therapy and exercise therapy.

Outcome markers for rotator cuff lesions patients; Pursuant to studies, the visual analogue scale (VAS) score, the shoulder pain & disability index (SPADI), & other metrics are used to evaluate the effects of hypertonic dextrose proliferation treatment on individuals with rotator cuff diseases. Flexion (3), abduction (4), internal rotation (5), and external rotation (6). Using at least one of the aforementioned scales, the literature that was analysed for this study assessed the outcome measures.

The databases Cochrane PubMed, Library, Web of Science and EMbase, are retrieved by the computer. To do a literary search, you must first hunt for relevant papers in English databases, then utilise a mix of topic words & keywords to narrow down your search results, & last use “MeSH Terms” to pinpoint the subject terms.

Extraction of data & Assessment of Quality:

After the first review of the abstract, two researchers independently conducted the procedure of literature screening. The entire text was then read in order to gain the results of the literary screening. Researchers may contrast screening results, discuss contradictory literature, or get in touch with a third researcher until the results are agreed upon. Among the data that were extracted are fundamental details about the literature, research kind, study object, intervention content, sample size, outcome measures, etc.

This meta-analysis was performed using Review Manager (RevMan). The standardised mean difference (SMD) & 95%Letters to the Zone (confidence interval, CI) are employed as a measure of impact. (2) To determine if there is heterogeneity among research, chi-square tests are performed; if P > 0.1, I2<50%, and the included studies were considered to be more homogenous, then there was less heterogeneity. It is appropriate to perform a fixed-effects model meta analysis if P < 0.1, I2 > = 50%, and heterogeneity were found in the encompassed research. Investigate diverse sources, Meta analyses using a random-effects model are done when there is no clinical heterogeneity. Subgroup studies of possible differences in qualitative traits were also carried out.