Chakhtoura Z, Canonico M, Gompel A, Scarabin PY, Plu-Bureau G. Progestogen-only contraceptives and the risk of acute myocardial infarction: a meta-analysis. J Clin Endocrinol Metab. 2011;96(4):1169–74.

Article  CAS  PubMed  Google Scholar 

Puerto E, Viana-Tejedor A, Martinez-Selles M, Dominguez-Perez L, Moreno G, Martin-Asenjo R, et al. Temporal trends in Mechanical complications of Acute myocardial infarction in the Elderly. J Am Coll Cardiol. 2018;72(9):959–66.

Article  PubMed  Google Scholar 

Alleman RJ, Tsang AM, Ryan TE, Patteson DJ, McClung JM, Spangenburg EE, et al. Exercise-induced protection against reperfusion arrhythmia involves stabilization of mitochondrial energetics. Am J Physiol Heart Circ Physiol. 2016;310(10):H1360–70.

Article  PubMed  PubMed Central  Google Scholar 

Batacan RB Jr., Duncan MJ, Dalbo VJ, Buitrago GL, Fenning AS. Effect of different intensities of physical activity on cardiometabolic markers and vascular and cardiac function in adult rats fed with a high-fat high-carbohydrate diet. J Sport Health Sci. 2018;7(1):109–19.

Article  PubMed  Google Scholar 

Tao L, Bei Y, Lin S, Zhang H, Zhou Y, Jiang J, et al. Exercise Training Protects against Acute Myocardial Infarction via Improving Myocardial Energy Metabolism and mitochondrial Biogenesis. Cell Physiol Biochem. 2015;37(1):162–75.

Article  CAS  PubMed  Google Scholar 

Thijssen DHJ, Benda NMM, Kerstens TP, Seeger JPH, van Dijk APJ, Hopman MTE. 12-Week Exercise Training, Independent of the type of Exercise, attenuates endothelial ischaemia-reperfusion Injury in Heart failure patients. Front Physiol. 2019;10:264.

Article  PubMed  PubMed Central  Google Scholar 

Garza MA, Wason EA, Zhang JQ. Cardiac remodeling and physical training post myocardial infarction. World J Cardiol. 2015;7(2):52–64.

Article  PubMed  PubMed Central  Google Scholar 

Haykowsky M, Scott J, Esch B, Schopflocher D, Myers J, Paterson I, et al. A meta-analysis of the effects of exercise training on left ventricular remodeling following myocardial infarction: start early and go longer for greatest exercise benefits on remodeling. Trials. 2011;12:92.

Article  PubMed  PubMed Central  Google Scholar 

Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, et al. Heart disease and stroke statistics–2015 update: a report from the American Heart Association. Circulation. 2015;131(4):e29–322.

PubMed  Google Scholar 

Pagan LU, Gomes MJ, Martinez PF, Okoshi MP. Oxidative stress and heart failure: mechanisms, signalling pathways, and therapeutics. Oxid Med Cell Longev. 2022;2022:9829505.

Article  PubMed  PubMed Central  Google Scholar 

Xie B, Yan X, Cai X, Li J. Effects of high-intensity interval training on aerobic capacity in Cardiac patients: a systematic review with Meta-analysis. Biomed Res Int. 2017;2017:5420840.

Article  PubMed  PubMed Central  Google Scholar 

Li HL, Zhuo ML, Wang D, Wang AB, Cai H, Sun LH, et al. Targeted cardiac overexpression of A20 improves left ventricular performance and reduces compensatory hypertrophy after myocardial infarction. Circulation. 2007;115(14):1885–94.

Article  CAS  PubMed  Google Scholar 

Nakamura K, Kusano K, Nakamura Y, Kakishita M, Ohta K, Nagase S, et al. Carvedilol decreases elevated oxidative stress in human failing myocardium. Circulation. 2002;105(24):2867–71.

Article  CAS  PubMed  Google Scholar 

Hori M, Nishida K. Oxidative stress and left ventricular remodelling after myocardial infarction. Cardiovasc Res. 2009;81(3):457–64.

Article  CAS  PubMed  Google Scholar 

Hanif W, Alex L, Su Y, Shinde AV, Russo I, Li N, et al. Left atrial remodeling, hypertrophy, and fibrosis in mouse models of heart failure. Cardiovasc Pathol. 2017;30:27–37.

Article  PubMed  PubMed Central  Google Scholar 

Vilahur G, Juan-Babot O, Pena E, Onate B, Casani L, Badimon L. Molecular and cellular mechanisms involved in cardiac remodeling after acute myocardial infarction. J Mol Cell Cardiol. 2011;50(3):522–33.

Article  CAS  PubMed  Google Scholar 

Gabriel-Costa D. The pathophysiology of myocardial infarction-induced heart failure. Pathophysiology. 2018;25(4):277–84.

Article  CAS  PubMed  Google Scholar 

Liang Q, Cai M, Zhang J, Song W, Zhu W, Xi L, et al. Role of muscle-specific histone methyltransferase (Smyd1) in Exercise-Induced cardioprotection against pathological remodeling after myocardial infarction. Int J Mol Sci. 2020;21:19.

Article  Google Scholar 

Biernacka A, Dobaczewski M, Frangogiannis NG. TGF-beta signaling in fibrosis. Growth Factors. 2011;29(5):196–202.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lijnen PJ, Petrov VV, Fagard RH. Induction of cardiac fibrosis by transforming growth factor-beta(1). Mol Genet Metab. 2000;71(1–2):418–35.

Article  CAS  PubMed  Google Scholar 

Ikeuchi M, Tsutsui H, Shiomi T, Matsusaka H, Matsushima S, Wen J, et al. Inhibition of TGF-beta signaling exacerbates early cardiac dysfunction but prevents late remodeling after infarction. Cardiovasc Res. 2004;64(3):526–35.

Article  CAS  PubMed  Google Scholar 

Roberts AB, Derynck R. Meeting report: signaling schemes for TGF-beta. Sci STKE. 2001;2001(113):pe43.

CAS  PubMed  Google Scholar 

Liang B, Zhang XX, Li R, Zhu YC, Tian XJ, Gu N. Guanxin V alleviates acute myocardial infarction by restraining oxidative stress damage, apoptosis, and fibrosis through the TGF-beta1 signalling pathway. Phytomedicine. 2022;100:154077.

Article  PubMed  Google Scholar 

Ma Y, Kuang Y, Bo W, Liang Q, Zhu W, Cai M et al. Exercise Training Alleviates Cardiac Fibrosis through Increasing Fibroblast Growth Factor 21 and Regulating TGF-beta1-Smad2/3-MMP2/9 Signaling in Mice with Myocardial Infarction. Int J Mol Sci. 2021;22(22).

Liu D, Zeng X, Li X, Mehta JL, Wang X. Role of NLRP3 inflammasome in the pathogenesis of cardiovascular diseases. Basic Res Cardiol. 2018;113(1):5.

Article  PubMed  Google Scholar 

Zhang J, Huang L, Shi X, Yang L, Hua F, Ma J, et al. Metformin protects against myocardial ischemia-reperfusion injury and cell pyroptosis via AMPK/NLRP3 inflammasome pathway. Aging. 2020;12(23):24270–87.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng Y, Cheng L, Gao X, Chen S, Wu P, Wang C, et al. Covalent modification of Keap1 at Cys77 and Cys434 by pubescenoside a suppresses oxidative stress-induced NLRP3 inflammasome activation in myocardial ischemia-reperfusion injury. Theranostics. 2021;11(2):861–77.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mezzaroma E, Toldo S, Farkas D, Seropian IM, Van Tassell BW, Salloum FN, et al. The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse. Proc Natl Acad Sci U S A. 2011;108(49):19725–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Su Q, Li L, Sun Y, Yang H, Ye Z, Zhao J. Effects of the TLR4/Myd88/NF-kappaB signaling pathway on NLRP3 inflammasome in Coronary Microembolization-Induced Myocardial Injury. Cell Physiol Biochem. 2018;47(4):1497–508.

Article  CAS  PubMed  Google Scholar 

Li H, Hu D, Chen G, Zheng D, Li S, Lin Y, et al. Adropin-based dual treatment enhances the therapeutic potential of mesenchymal stem cells in rat myocardial infarction. Cell Death Dis. 2021;12(6):505.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou Z, Ma D, Zhou Y, Zhang K, Liu Y, Wang Z, et al. The Carthamus tinctorius L. and Lepidium apetalum Willd. Drug pair inhibits EndMT through the TGFbeta1/Snail Signaling Pathway in the treatment of myocardial fibrosis. Evid Based Complement Alternat Med. 2023;2023:6018375.

Article  PubMed  PubMed Central  Google Scholar 

Yao C, Zhou X, Weng W, Poonit K, Sun C, Yan H. Aligned nanofiber nerve conduits inhibit alpha smooth muscle actin expression and collagen proliferation by suppressing TGF-beta1/SMAD signaling in traumatic neuromas. Exp Ther Med. 2021;22(6):1414.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu Q, Miao X, Zhang J, Xiang L, Li X, Bao X, et al. Astrocytic YAP protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model through TGF-beta signaling. Theranostics. 2021;11(17):8480–99.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo H, Zhang Q, Li R, Seshadri VD. Nigericin abrogates maternal and embryonic oxidative stress in the Streptozotocin-Induced Diabetic pregnant rats. Appl Biochem Biotechnol. 2023;195(2):801–15.

Article  CAS  PubMed  Google Scholar 

Jorge L, Rodrigues B, Rosa KT, Malfitano C, Loureiro TC, Medeiros A, et al. Cardiac and peripheral adjustments induced by early exercise training intervention were associated with autonomic improvement in infarcted rats: role in functional capacity and mortality. Eur Heart J. 2011;32(7):904–12.

Article  PubMed  Google Scholar 

Rodrigues B, Figueroa DM, Mostarda CT, Heeren MV, Irigoyen MC, De Angelis K. Maximal exercise test is a useful method for physical capacity and oxygen consumption determination in streptozotocin-diabetic rats. Cardiovasc Diabetol. 2007;6:38.

Article  PubMed  PubMed Central