Shin YJ, Choung HW, Lee JH et al (2019) Association of periodontitis with oral cancer: a case-control study. J Dent Res 98(5):526–533

Article  CAS  PubMed  Google Scholar 

Kavarthapu A, Gurumoorthy K (2021) Linking chronic periodontitis and oral cancer: a review. Oral Oncol 121:105375

Article  PubMed  Google Scholar 

Sachdeva S, Saluja H, Mani A, Sonkar T (2020) Interleukins in periodontics. J Head Neck Physicians Surg 8(3):70

Google Scholar 

Kaliński P, Hilkens CM, Snijders A et al (1997) IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells. J Immunol 159(1):28–35

Article  PubMed  Google Scholar 

Del Vecchio M, Bajetta E, Canova S et al (2007) Interleukin-12: biological properties and clinical application. Clin Cancer Res 13(16):4677–4685

Article  PubMed  Google Scholar 

Mirlekar B, Pylayeva-Gupta Y (2021) IL-12 family cytokines in cancer and immunotherapy. Cancers 13(2):167

Article  CAS  PubMed  PubMed Central  Google Scholar 

Presky DH, Yang H, Minetti LJ et al (1996) A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc Natl Acad Sci USA 93(24):14002–14007

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang KS, Frank DA, Ritz J (2000) Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up-regulation of the interleukin-12 receptor and STAT4. Blood 95(10):3183–3190

Article  CAS  PubMed  Google Scholar 

Ye J, Huang Y, Que B et al (2018) Interleukin-12p35 knock out aggravates doxorubicin-induced cardiac injury and dysfunction by aggravating the inflammatory response, oxidative stress, apoptosis and autophagy in mice. E Bio Medicine 35:29–39

Google Scholar 

Zwirner NW, Ziblat A (2017) Regulation of nk cell activation and effector functions by the IL-12 family of cytokines: the case of IL-27. Front Immunol 8:25

Article  PubMed  PubMed Central  Google Scholar 

Angiolillo AL, Sgadari C, Tosato G (1996) A role for the interferon-inducible protein 10 in inhibition of angiogenesis by interleukin-12. Ann NY Acad Sci 795:158–167

Article  CAS  PubMed  Google Scholar 

Kerkar SP, Leonardi AJ, van Panhuys N et al (2013) Collapse of the tumor stroma is triggered by IL-12 induction of Fas. Mol Ther 21(7):1369–1377

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kerkar SP, Goldszmid RS, Muranski P et al (2011) IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors. J Clin Investig 121(12):4746–4757

Article  CAS  PubMed  PubMed Central  Google Scholar 

Suzuki S, Umezu Y, Saijo Y et al (1998) Exogenous recombinant human IL-12 augments MHC class I antigen expression on human cancer cells in vitro. Tohoku J Exp Med 185(3):223–226

Article  CAS  PubMed  Google Scholar 

Chiocca EA, Yu JS, Lukas RV et al (2019) Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: results of a phase 1 trial. Science Translational Medicine 11(505):eaaw5680

Article  PubMed  PubMed Central  Google Scholar 

Hewitt SL, Bailey D, Zielinski J et al (2020) Intratumoral IL12 mRNA therapy promotes TH1 transformation of the tumor microenvironment. Clin Cancer Res 26(23):6284–6298

Article  CAS  PubMed  Google Scholar 

Bekaii-Saab TS, Roda JM, Guenterberg KD et al (2009) A phase I trial of paclitaxel and trastuzumab in combination with interleukin-12 in patients with her2/neu-expressing malignancies. Mol Cancer Ther 8(11):2983–2991

Article  CAS  PubMed  PubMed Central  Google Scholar 

Díaz-Montero CM, El Naggar S, Al Khami A et al (2008) Priming of naive CD8+ T cells in the presence of IL-12 selectively enhances the survival of CD8+CD62Lhi cells and results in superior anti-tumor activity in a tolerogenic murine model. Cancer Immunol Immunother 57(4):563–572

Article  PubMed  Google Scholar 

De la Rosa M, Zacarias GJ, Johnston DA, Radike AW (1979) Plaque growth and removal with daily toothbrushing. J Periodontol 50(12):661–664

Article  PubMed  Google Scholar 

Truyen E, Coteur L, Dilissen E et al (2006) Evaluation of airway inflammation by quantitative Th1/Th2 cytokine mRNA measurement in sputum of asthma patients. Thorax 61(3):202–208

Article  CAS  PubMed  PubMed Central  Google Scholar 

Majeed ZN, Jassim SD, Kamil ZH (2023) Assessment of salivary and gingival crevicular fluids IL6, IL-8, IL-12, and IL-17 levels in healthy subjects and patients with periodontal disease. J Oral Maxillofac Pathol 27(3):494–498. https://doi.org/10.4103/jomfp.jomfp_170_23

Article  PubMed  PubMed Central  Google Scholar 

Sharma A, Khattak BP, Naagtilak S et al (2014) Effect of periodontal therapy on salivary interleukin-12 levels in chronic periodontitis. J Clin Diagn Res 8(10):ZC90

PubMed  PubMed Central  Google Scholar 

Polson AM, Goodson JM (1985) Periodontal diagnosis. Current status and future needs. J Periodontol 56(1):25–34

Article  CAS  PubMed  Google Scholar 

Babitha GA, Nagpal D, Shripad SJ et al (2016) Interleukins in periodontal health and disease. Indian J Dent Adv 8(2):18–32

Google Scholar 

Drisko CH (2001) Nonsurgical periodontal therapy. Periodontol 25(1):77–88

Article  CAS  Google Scholar 

Söder B, Yakob M, Meurman JH et al (2012) The association of dental plaque with cancer mortality in Sweden. A longitudinal study. BMJ 2(3):e001083

Google Scholar 

Moraes RC, Dias FL, Figueredo CM, Fischer RG (2016) Association between chronic periodontitis and oral/oropharyngeal cancer. Braz Dent J 27:261–266

Article  PubMed  Google Scholar 

Tibúrcio-Machado CS, Michelon C, Zanatta FB et al (2021) The global prevalence of apical periodontitis: a systematic review and meta-analysis. Int Endod J 54(5):712–735

Article  PubMed  Google Scholar 

Rylev M, Kilian M (2008) Prevalence and distribution of principal periodontal pathogens worldwide. J Clin Periodontol 35:346–361

Article  PubMed  Google Scholar 

Schenkein HA (1999) The pathogenesis of periodontal diseases. J Periodontol 70(4):457–470

Article  Google Scholar 

Navazesh M (1993) Methods for collecting saliva. Ann NY Acad Sci 694(1):72–77

Article  CAS  PubMed  Google Scholar 

Löe H, Silness J (1963) Periodontal disease in pregnancy I. Prevalence and severity Acta Odontologica Scandinavica 21(6):533–551

Article  PubMed  Google Scholar 

Silness J, Löe H (1964) Periodontal disease in pregnancy II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand 22(1):121–135

Article  CAS  PubMed  Google Scholar 

Johnson RB, Wood N, Serio FG (2004) Interleukin-11 and IL-17 and the pathogenesis of periodontal disease. J Periodontol 75(1):37–43

Article  CAS  PubMed  Google Scholar 

Eke PI, Page RC, Wei L et al (2012) Update of the case definitions for population-based surveillance of periodontitis. J Periodontol 83(12):1449–1454

Article  PubMed  PubMed Central  Google Scholar 

Vignali DAA, Kuchroo VK (2012) IL-12 family cytokines: immunological playmakers. Nat Immunol 13(8):722–728

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chang H-D, Radbruch A (2007) The pro- and anti-inflammatory potential of interleukin-12. Ann N Y Acad Sci 1109:40–46

Article  CAS  PubMed  Google Scholar 

Claudino M, Garlet TP, Cardoso CRB et al (2010) Down-regulation of expression of osteoblast and osteocyte markers in periodontal tissues associated with the spontaneous alveolar bone loss of interleukin-10 knockout mice. Eur J Oral Sci 118(1):19–28

Article  CAS  PubMed  Google Scholar 

Opal SM, DePalo VA (2000) Anti-inflammatory cytokines. Chest 117(4):1162–1172

Article  CAS  PubMed  Google Scholar 

Honda T, Domon H, Okui T et al (2006) Balance of inflammatory response in stable gingivitis and progressive periodontitis lesions. Clin Exp Immunol 144(1):35–40

Article